ArticleBMC genomics2014
Quantitative trait loci mapping for canine hip dysplasia and its related traits in UK Labrador Retrievers.
Article in BMC genomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Genome-wide association studies for canine hip dysplasia in single and multiple populations - implications and potential novel risk loci.BMC genomics · 2021Pooled it
- Prevalence of hip and elbow dysplasia in young adult dogs in Sweden.The Veterinary record · 2026Article
- Genome wide association study in Swedish Labrador retrievers identifies genetic loci associated with hip dysplasia and body weight.Scientific reports · 2024Article
- NADPH Oxidase 3: Beyond the Inner Ear.Antioxidants (Basel, Switzerland) · 2024Review
- Mechanical osteoarthritis of the hip in a one medicine concept: a narrative review.BMC veterinary research · 2023Review
- Whole exome sequencing of 28 families of Danish descent reveals novel candidate genes and pathways in developmental dysplasia of the hip.Molecular genetics and genomics : MGG · 2023Article
- Across-breed genetic investigation of canine hip dysplasia, elbow dysplasia, and anterior cruciate ligament rupture using whole-genome sequencing.Frontiers in genetics · 2022Article
- Article
- Genomic Prediction of Two Complex Orthopedic Traits Across Multiple Pure and Mixed Breed Dogs.Frontiers in genetics · 2021Article
- Article
- The association of genetic polymorphisms of bone formation genes with canine hip dysplasia.Iranian journal of veterinary research · 2020Article
- Article
- Genome-Wide Association Study towards Genomic Predictive Power for High Production and Quality of Milk in American Alpine Goats.International journal of genomics · 2020Article
- Genetic dissection of canine hip dysplasia phenotypes and osteoarthritis reveals three novel loci.BMC genomics · 2019Article
- Novel protective and risk loci in hip dysplasia in German Shepherds.PLoS genetics · 2019Article
- Effectiveness of Canine Hip Dysplasia and Elbow Dysplasia Improvement Programs in Six UK Pedigree Breeds.Frontiers in veterinary science · 2019Article
- Prevalence of Canine Hip Dysplasia in Switzerland Between 1995 and 2016-A Retrospective Study in 5 Common Large Breeds.Frontiers in veterinary science · 2019Article
- Accuracy of genotype imputation in Labrador Retrievers.Animal genetics · 2018Article
- Joint Genomic Prediction of Canine Hip Dysplasia in UK and US Labrador Retrievers.Frontiers in genetics · 2018Article
- Genomic data illuminates demography, genetic structure and selection of a popular dog breed.BMC genomics · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundCanine hip dysplasia (CHD) is characterised by a malformation of the hip joint, leading to osteoarthritis and lameness. Current breeding schemes against CHD have resulted in measurable but moderate responses. The application of marker-assisted selection, incorporating specific markers associated with the disease, or genomic selection, incorporating genome-wide markers, has the potential to dramatically improve results of breeding schemes. Our aims were to identify regions associated with hip dysplasia or its related traits using genome and chromosome-wide analysis, study the linkage disequilibrium (LD) in these regions and provide plausible gene candidates. This study is focused on the UK Labrador Retriever population, which has a high prevalence of the disease and participates in a recording program led by the British Veterinary Association (BVA) and The Kennel Club (KC).
resultsTwo genome-wide and several chromosome-wide QTLs affecting CHD and its related traits were identified, indicating regions related to hip dysplasia.
conclusionConsistent with previous studies, the genetic architecture of CHD appears to be based on many genes with small or moderate effect, suggesting that genomic selection rather than marker-assisted selection may be an appropriate strategy for reducing this disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.