ArticleThe American journal of pathology1989
A novel monoclonal antibody (OPD4) recognizing a helper/inducer T cell subset. Its application to paraffin-embedded tissues.
Article in The American journal of pathology, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Differential cross-reactivity of monoclonal antibody OPD4 (anti-CD45RO) in macaques.Developmental and comparative immunology · 2008Article
- Article
- Reassessment of diagnostic criteria in cutaneous lymphocytic infiltrates.Sao Paulo medical journal = Revista paulista de medicina · 2004Article
- T lymphocytes, CD68-positive cells and vascularisation in thyroid carcinomas.Journal of cancer research and clinical oncology · 1994Article
- Immunohistochemical characterization of mononuclear cells in delayed hypersensitivity reactions to Paracoccidiodes brasiliensis (paracoccidioidin test).Mycopathologia · 1993Article
- Effects of fixation and varying target length on the sensitivity of polymerase chain reaction for detection of human T-cell leukemia virus type I proviral DNA in formalin-fixed tissue sections.Journal of clinical microbiology · 1993Article
- Human atherosclerosis. IV. Immunocytochemical analysis of cell activation and proliferation in lesions of young adults.The American journal of pathology · 1993Article
- Lymphocytes infiltrating primary cutaneous neoplasms selectively express the cutaneous lymphocyte-associated antigen (CLA).The American journal of pathology · 1993Article
- Human T lymphotropic virus type I associated myelopathy with pulmonary and cutaneous lesions.Journal of clinical pathology · 1993Article
- T lymphocytes expressing HECA-452 epitope are present in cutaneous acute graft-versus-host disease and erythema multiforme, but not in acute graft-versus-host disease in gut organs.The American journal of pathology · 1992Article
- Infiltration of helper/inducer T lymphocytes heralds central nervous system damage in human T-cell leukemia virus infection.The American journal of pathology · 1992Article
- Article
- Human atherosclerosis. III. Immunocytochemical analysis of the cell composition of lesions of young adults.The American journal of pathology · 1992Article
- Monoclonal antibody OPD4 is reactive with CD45RO, but differs from UCHL1 by the absence of monocyte reactivity.The American journal of pathology · 1991Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A novel monoclonal antibody (MAb), OPD4, reactive with a helper/inducer (H/I) subset of T cells in formalin-fixed, paraffin-embedded tissue sections, has been identified through immunization with an activated H/I T cell line, namely DL40. The antibody is an IgG1 antibody and it recognizes an antigen with a molecular weight of 200 kd, corresponding to that of leukocyte common antigen. OPD4+/CD4+ T cells provided better help for pokeweed mitogen-stimulated polyclonal IgG production than OPD4-/CD4+ T cells. OPD4 recognized the H/I T cell subset even in paraffin-embedded tissue sections, but did not recognize nonhematopoietic cells, suppressor/cytotoxic T cells, B cells, monocytes in the peripheral blood, or other normal hematopoietic cells as examined by the flow cytometric and immunoperoxidase methods. Besides the lymphoid cells, OPD4 reacted with a number of histiocytes (epithelioid cells) in tissues from sarcoidosis and tuberculosis. For the neoplastic lesions, OPD4 reacted with approximately half of the cases of T cell lymphomas. Consequently, OPD4 may be useful for the diagnosis and study of malignant lymphomas and other related lesions.
Indexed as
Identifiers
2527008PMC1879957What OpenQuestion holds
Registered trials
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