ArticleJournal of the American Society of Nephrology : JASN2015
Copeptin is associated with kidney length, renal function, and prevalence of simple cysts in a population-based study.
Article in Journal of the American Society of Nephrology : JASN, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Pooled it
- Plasma copeptin levels predict disease progression and tolvaptan efficacy in autosomal dominant polycystic kidney disease.Kidney international · 2019Trial
- Urine Osmolality, Response to Tolvaptan, and Outcome in Autosomal Dominant Polycystic Kidney Disease: Results from the TEMPO 3:4 Trial.Journal of the American Society of Nephrology : JASN · 2017Trial
- Efferocytosis: the art of cellular clearance and novel perspectives in disease therapy.Molecular cancer · 2025Review
- Association of serum copeptin and urinary uromodulin with kidney function, blood pressure and albuminuria at 6 weeks post-partum in pre-eclampsia.Frontiers in cardiovascular medicine · 2024Article
- Copeptin: a novel prognostic biomarker in trauma: a review article.Journal of health, population, and nutrition · 2023Review
- The role of copeptin in kidney disease.Endocrine · 2023Review
- Plasma copeptin is increased and associated with smaller kidney volume in young adults born very preterm.Clinical kidney journal · 2022Article
- The presence of simple renal cysts is associated with an increased risk of albuminuria in young adults.The Korean journal of internal medicine · 2022Article
- Copeptin is independently associated with vascular calcification in chronic kidney disease stage 5.BMC nephrology · 2020Article
- Association between simple renal cyst and kidney damage in a Chinese cohort study.Renal failure · 2019Article
- Simple renal cysts are associated with increased arterial stiffness in a Taiwanese population.Hypertension research : official journal of the Japanese Society of Hypertension · 2019Article
- Increased water intake reduces long-term renal and cardiovascular disease progression in experimental polycystic kidney disease.PloS one · 2019Article
- Vasopressin-aquaporin-2 pathway: recent advances in understanding water balance disorders.F1000Research · 2019Review
- Salt, water and nephron: Mechanisms of action and link to hypertension and chronic kidney disease.Nephrology (Carlton, Vic.) · 2018Review
- Increased risk of kidney damage among Chinese adults with simple renal cyst.International urology and nephrology · 2018Article
- Effect of increased water intake on plasma copeptin in healthy adults.European journal of nutrition · 2018Article
- Plasma copeptin and chronic kidney disease risk in 3 European cohorts from the general population.JCI insight · 2018Article
- Copeptin and insulin resistance: effect modification by age and 11 β-HSD2 activity in a population-based study.Journal of endocrinological investigation · 2018Article
- Dietary Influence on Body Fluid Acid-Base and Volume Balance: The Deleterious "Norm" Furthers and Cloaks Subclinical Pathophysiology.Nutrients · 2018Article
Corrections and comments
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Authors and funding
16 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Arginine vasopressin (AVP) has a key role in osmoregulation by facilitating water transport in the collecting duct. Recent evidence suggests that AVP may have additional effects on renal function and favor cyst growth in polycystic kidney disease. Whether AVP also affects kidney structure in the general population is unknown. We analyzed the association of copeptin, an established surrogate for AVP, with parameters of renal function and morphology in a multicentric population-based cohort. Participants from families of European ancestry were randomly selected in three Swiss cities. We used linear multilevel regression analysis to explore the association of copeptin with renal function parameters as well as kidney length and the presence of simple renal cysts assessed by ultrasound examination. Copeptin levels were log-transformed. The 529 women and 481 men had median copeptin levels of 3.0 and 5.2 pmol/L, respectively (P<0.001). In multivariable analyses, the copeptin level was associated inversely with eGFR (β=-2.1; 95% confidence interval [95% CI], -3.3 to -0.8; P=0.002) and kidney length (β=-1.2; 95% CI, -1.9 to -0.4; P=0.003) but positively with 24-hour urinary albumin excretion (β=0.11; 95% CI, 0.01 to 0.20; P=0.03) and urine osmolality (β=0.08; 95% CI, 0.05 to 0.10; P<0.001). A positive association was found between the copeptin level and the presence of renal cysts (odds ratio, 1.6; 95% CI, 1.1 to 2.4; P=0.02). These results suggest that AVP has a pleiotropic role in renal function and may favor the development of simple renal cysts.
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