ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2014
Association and ancestry analysis of sequence variants in ADH and ALDH using alcohol-related phenotypes in a Native American community sample.
Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Effect of alcohol on blood pressure.The Cochrane database of systematic reviews · 2020Pooled it
- Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use.Biological psychiatry · 2019Pooled it
- The Promise of Genetics in Alcohol Use Disorders and the Problems of Phenotype, Polygenetic Architecture, Ancestry, and Comorbidity.The American journal of psychiatry · 2025Article
- Alcohol consumption questionnaire: Scale development in a sample of Mexican American young adults and association with ADH7.Alcohol (Fayetteville, N.Y.) · 2024Article
- Human genetics and epigenetics of alcohol use disorder.The Journal of clinical investigation · 2024Review
- Genetic factors associated with suicidal behaviors and alcohol use disorders in an American Indian population.Molecular psychiatry · 2024Article
- Genetic Factors Associated with Suicidal Behaviors and Alcohol Use Disorders in an American Indian Population.Research square · 2023Article
- Long tracks of homozygosity predict the severity of alcohol use disorders in an American Indian population.Molecular psychiatry · 2021Article
- Genetic loci for alcohol-related life events and substance-induced affective symptoms: indexing the "dark side" of addiction.Translational psychiatry · 2019Article
- Alcohol Dehydrogenases, Aldehyde Dehydrogenases, and Alcohol Use Disorders: A Critical Review.Alcoholism, clinical and experimental research · 2018Review
- Spatial Epidemiology of Alcohol- and Drug-Related Health Problems Among Northern Plains American Indians: Nebraska and South Dakota, 2007 to 2012.Alcoholism, clinical and experimental research · 2018Article
- Associations Between Genomic Variants in Alcohol Dehydrogenase Genes and Alcohol Symptomatology in American Indians and European Americans: Distinctions and Convergence.Alcoholism, clinical and experimental research · 2017Article
- Single nucleotide polymorphisms in the REG-CTNNA2 region of chromosome 2 and NEIL3 associated with impulsivity in a Native American sample.Genes, brain, and behavior · 2016Article
- Drosophila and Caenorhabditis elegans as Discovery Platforms for Genes Involved in Human Alcohol Use Disorder.Alcoholism, clinical and experimental research · 2015Review
- Protective variant associated with alcohol dependence in a Mexican American cohort.BMC medical genetics · 2014Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Higher rates of alcohol use and other drug-dependence have been observed in some Native American (NA) populations relative to other ethnic groups in the US. Previous studies have shown that alcohol dehydrogenase (ADH) genes and aldehyde dehydrogenase (ALDH) genes may affect the risk of development of alcohol dependence, and that polymorphisms within these genes may differentially affect risk for the disorder depending on the ethnic group evaluated. We evaluated variations in the ADH and ALDH genes in a large study investigating risk factors for substance use in a NA population. We assessed ancestry admixture and tested for associations between alcohol-related phenotypes in the genomic regions around the ADH1-7 and ALDH2 and ALDH1A1 genes. Seventy-two ADH variants showed significant evidence of association with a severity level of alcohol drinking-related dependence symptoms phenotype. These significant variants spanned across the entire 7 ADH gene cluster regions. Two significant associations, one in ADH and one in ALDH2, were observed with alcohol dependence diagnosis. Seventeen variants showed significant association with the largest number of alcohol drinks ingested during any 24-hour period. Variants in or near ADH7 were significantly negatively associated with alcohol-related phenotypes, suggesting a potential protective effect of this gene. In addition, our results suggested that a higher degree of NA ancestry is associated with higher frequencies of potential risk variants and lower frequencies of potential protective variants for alcohol dependence phenotypes.
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