Evidence map›Paper›PMID 25269698›Full record

ArticleJournal of the National Cancer Institute2014

Obesity and risk of esophageal adenocarcinoma and Barrett's esophagus: a Mendelian randomization study.

Aaron P Thrift, Nicholas J Shaheen, Marilie D Gammon, Leslie Bernstein, Brian J Reid, Lynn Onstad, Harvey A Risch, Geoffrey Liu, Nigel C Bird, Anna H Wu and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the National Cancer Institute, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed, 8 pooled it
15.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 8 syntheses or guidelines pooled it, 181 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Esophageal cancer: from pathogenesis to precision therapies.Signal transduction and targeted therapy · 2026
    Review
  10. Endoscopic Screening of Barrett's Esophagus.Gastrointestinal endoscopy clinics of North America · 2026
    Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Exploring the impact of body mass index on tumor biology and cancer development.Journal of cancer research and clinical oncology · 2024
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors at 10 institutions in 6 countries.

Aaron P ThriftDivision of Public Health Sciences (APT, LO, TLV) and Division of Human Biology (BJR), Fred Hutchinson Cancer Research Center, Seattle, WA; Cancer Control Group (APT, DCW) and Statistical Genetics (WEE, SM), QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Division of Gastroenterology and Hepatology, UNC School of Medicine (NJS) and Department of Epidemiology, School of Public Health (MDG), University of North Carolina, Chapel Hill, NC; Department of Population Sciences, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, CA (LB); Yale School of Public Health, Department of Chronic Disease Epidemiology, New Haven, CT (HAR); Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre-Ontario Cancer Institute, University of Toronto, Toronto, ON, Canada (GL); Department of Oncology, The Medical School, University of Sheffield, Sheffield, UK (NCB); Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA (AHW); Division of Research and Oakland Medical Center, Kaiser Permanente, Oakland, CA (DAC); Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN (YR), on behalf of the Mayo Clinic Esophageal Adenocarcinoma and Barrett's Esophagus Registry Consortium; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (SJC); Department of Epidemiology, MD Anderson Cancer Center, Houston, TX (WHC); Department of Surgery, University of Saskatchewan, Saskatoon SK, Canada (AGC); Department of Biostatistics, University of Washington School of Public Health, Seattle, WA (DML, RZ); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (WY); Division of Epidemiology, University of Leeds, Leeds, UK (LJH). athrift@fhcrc.org.
Nicholas J ShaheenDivision of Public Health Sciences (APT, LO, TLV) and Division of Human Biology (BJR), Fred Hutchinson Cancer Research Center, Seattle, WA; Cancer Control Group (APT, DCW) and Statistical Genetics (WEE, SM), QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Division of Gastroenterology and Hepatology, UNC School of Medicine (NJS) and Department of Epidemiology, School of Public Health (MDG), University of North Carolina, Chapel Hill, NC; Department of Population Sciences, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, CA (LB); Yale School of Public Health, Department of Chronic Disease Epidemiology, New Haven, CT (HAR); Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre-Ontario Cancer Institute, University of Toronto, Toronto, ON, Canada (GL); Department of Oncology, The Medical School, University of Sheffield, Sheffield, UK (NCB); Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA (AHW); Division of Research and Oakland Medical Center, Kaiser Permanente, Oakland, CA (DAC); Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN (YR), on behalf of the Mayo Clinic Esophageal Adenocarcinoma and Barrett's Esophagus Registry Consortium; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (SJC); Department of Epidemiology, MD Anderson Cancer Center, Houston, TX (WHC); Department of Surgery, University of Saskatchewan, Saskatoon SK, Canada (AGC); Department of Biostatistics, University of Washington School of Public Health, Seattle, WA (DML, RZ); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (WY); Division of Epidemiology, University of Leeds, Leeds, UK (LJH).
Marilie D GammonDivision of Public Health Sciences (APT, LO, TLV) and Division of Human Biology (BJR), Fred Hutchinson Cancer Research Center, Seattle, WA; Cancer Control Group (APT, DCW) and Statistical Genetics (WEE, SM), QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Division of Gastroenterology and Hepatology, UNC School of Medicine (NJS) and Department of Epidemiology, School of Public Health (MDG), University of North Carolina, Chapel Hill, NC; Department of Population Sciences, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, CA (LB); Yale School of Public Health, Department of Chronic Disease Epidemiology, New Haven, CT (HAR); Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre-Ontario Cancer Institute, University of Toronto, Toronto, ON, Canada (GL); Department of Oncology, The Medical School, University of Sheffield, Sheffield, UK (NCB); Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA (AHW); Division of Research and Oakland Medical Center, Kaiser Permanente, Oakland, CA (DAC); Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN (YR), on behalf of the Mayo Clinic Esophageal Adenocarcinoma and Barrett's Esophagus Registry Consortium; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (SJC); Department of Epidemiology, MD Anderson Cancer Center, Houston, TX (WHC); Department of Surgery, University of Saskatchewan, Saskatoon SK, Canada (AGC); Department of Biostatistics, University of Washington School of Public Health, Seattle, WA (DML, RZ); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (WY); Division of Epidemiology, University of Leeds, Leeds, UK (LJH).
Leslie BernsteinDivision of Public Health Sciences (APT, LO, TLV) and Division of Human Biology (BJR), Fred Hutchinson Cancer Research Center, Seattle, WA; Cancer Control Group (APT, DCW) and Statistical Genetics (WEE, SM), QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Division of Gastroenterology and Hepatology, UNC School of Medicine (NJS) and Department of Epidemiology, School of Public Health (MDG), University of North Carolina, Chapel Hill, NC; Department of Population Sciences, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, CA (LB); Yale School of Public Health, Department of Chronic Disease Epidemiology, New Haven, CT (HAR); Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre-Ontario Cancer Institute, University of Toronto, Toronto, ON, Canada (GL); Department of Oncology, The Medical School, University of Sheffield, Sheffield, UK (NCB); Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA (AHW); Division of Research and Oakland Medical Center, Kaiser Permanente, Oakland, CA (DAC); Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN (YR), on behalf of the Mayo Clinic Esophageal Adenocarcinoma and Barrett's Esophagus Registry Consortium; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (SJC); Department of Epidemiology, MD Anderson Cancer Center, Houston, TX (WHC); Department of Surgery, University of Saskatchewan, Saskatoon SK, Canada (AGC); Department of Biostatistics, University of Washington School of Public Health, Seattle, WA (DML, RZ); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (WY); Division of Epidemiology, University of Leeds, Leeds, UK (LJH).
Brian J ReidDivision of Public Health Sciences (APT, LO, TLV) and Division of Human Biology (BJR), Fred Hutchinson Cancer Research Center, Seattle, WA; Cancer Control Group (APT, DCW) and Statistical Genetics (WEE, SM), QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Division of Gastroenterology and Hepatology, UNC School of Medicine (NJS) and Department of Epidemiology, School of Public Health (MDG), University of North Carolina, Chapel Hill, NC; Department of Population Sciences, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, CA (LB); Yale School of Public Health, Department of Chronic Disease Epidemiology, New Haven, CT (HAR); Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre-Ontario Cancer Institute, University of Toronto, Toronto, ON, Canada (GL); Department of Oncology, The Medical School, University of Sheffield, Sheffield, UK (NCB); Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA (AHW); Division of Research and Oakland Medical Center, Kaiser Permanente, Oakland, CA (DAC); Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN (YR), on behalf of the Mayo Clinic Esophageal Adenocarcinoma and Barrett's Esophagus Registry Consortium; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (SJC); Department of Epidemiology, MD Anderson Cancer Center, Houston, TX (WHC); Department of Surgery, University of Saskatchewan, Saskatoon SK, Canada (AGC); Department of Biostatistics, University of Washington School of Public Health, Seattle, WA (DML, RZ); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (WY); Division of Epidemiology, University of Leeds, Leeds, UK (LJH).
Lynn OnstadDivision of Public Health Sciences (APT, LO, TLV) and Division of Human Biology (BJR), Fred Hutchinson Cancer Research Center, Seattle, WA; Cancer Control Group (APT, DCW) and Statistical Genetics (WEE, SM), QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Division of Gastroenterology and Hepatology, UNC School of Medicine (NJS) and Department of Epidemiology, School of Public Health (MDG), University of North Carolina, Chapel Hill, NC; Department of Population Sciences, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, CA (LB); Yale School of Public Health, Department of Chronic Disease Epidemiology, New Haven, CT (HAR); Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre-Ontario Cancer Institute, University of Toronto, Toronto, ON, Canada (GL); Department of Oncology, The Medical School, University of Sheffield, Sheffield, UK (NCB); Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA (AHW); Division of Research and Oakland Medical Center, Kaiser Permanente, Oakland, CA (DAC); Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN (YR), on behalf of the Mayo Clinic Esophageal Adenocarcinoma and Barrett's Esophagus Registry Consortium; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (SJC); Department of Epidemiology, MD Anderson Cancer Center, Houston, TX (WHC); Department of Surgery, University of Saskatchewan, Saskatoon SK, Canada (AGC); Department of Biostatistics, University of Washington School of Public Health, Seattle, WA (DML, RZ); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (WY); Division of Epidemiology, University of Leeds, Leeds, UK (LJH).
Harvey A RischDivision of Public Health Sciences (APT, LO, TLV) and Division of Human Biology (BJR), Fred Hutchinson Cancer Research Center, Seattle, WA; Cancer Control Group (APT, DCW) and Statistical Genetics (WEE, SM), QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Division of Gastroenterology and Hepatology, UNC School of Medicine (NJS) and Department of Epidemiology, School of Public Health (MDG), University of North Carolina, Chapel Hill, NC; Department of Population Sciences, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, CA (LB); Yale School of Public Health, Department of Chronic Disease Epidemiology, New Haven, CT (HAR); Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre-Ontario Cancer Institute, University of Toronto, Toronto, ON, Canada (GL); Department of Oncology, The Medical School, University of Sheffield, Sheffield, UK (NCB); Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA (AHW); Division of Research and Oakland Medical Center, Kaiser Permanente, Oakland, CA (DAC); Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN (YR), on behalf of the Mayo Clinic Esophageal Adenocarcinoma and Barrett's Esophagus Registry Consortium; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (SJC); Department of Epidemiology, MD Anderson Cancer Center, Houston, TX (WHC); Department of Surgery, University of Saskatchewan, Saskatoon SK, Canada (AGC); Department of Biostatistics, University of Washington School of Public Health, Seattle, WA (DML, RZ); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (WY); Division of Epidemiology, University of Leeds, Leeds, UK (LJH).
Geoffrey LiuDivision of Public Health Sciences (APT, LO, TLV) and Division of Human Biology (BJR), Fred Hutchinson Cancer Research Center, Seattle, WA; Cancer Control Group (APT, DCW) and Statistical Genetics (WEE, SM), QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Division of Gastroenterology and Hepatology, UNC School of Medicine (NJS) and Department of Epidemiology, School of Public Health (MDG), University of North Carolina, Chapel Hill, NC; Department of Population Sciences, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, CA (LB); Yale School of Public Health, Department of Chronic Disease Epidemiology, New Haven, CT (HAR); Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre-Ontario Cancer Institute, University of Toronto, Toronto, ON, Canada (GL); Department of Oncology, The Medical School, University of Sheffield, Sheffield, UK (NCB); Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA (AHW); Division of Research and Oakland Medical Center, Kaiser Permanente, Oakland, CA (DAC); Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN (YR), on behalf of the Mayo Clinic Esophageal Adenocarcinoma and Barrett's Esophagus Registry Consortium; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (SJC); Department of Epidemiology, MD Anderson Cancer Center, Houston, TX (WHC); Department of Surgery, University of Saskatchewan, Saskatoon SK, Canada (AGC); Department of Biostatistics, University of Washington School of Public Health, Seattle, WA (DML, RZ); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (WY); Division of Epidemiology, University of Leeds, Leeds, UK (LJH).
Nigel C BirdDivision of Public Health Sciences (APT, LO, TLV) and Division of Human Biology (BJR), Fred Hutchinson Cancer Research Center, Seattle, WA; Cancer Control Group (APT, DCW) and Statistical Genetics (WEE, SM), QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Division of Gastroenterology and Hepatology, UNC School of Medicine (NJS) and Department of Epidemiology, School of Public Health (MDG), University of North Carolina, Chapel Hill, NC; Department of Population Sciences, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, CA (LB); Yale School of Public Health, Department of Chronic Disease Epidemiology, New Haven, CT (HAR); Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre-Ontario Cancer Institute, University of Toronto, Toronto, ON, Canada (GL); Department of Oncology, The Medical School, University of Sheffield, Sheffield, UK (NCB); Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA (AHW); Division of Research and Oakland Medical Center, Kaiser Permanente, Oakland, CA (DAC); Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN (YR), on behalf of the Mayo Clinic Esophageal Adenocarcinoma and Barrett's Esophagus Registry Consortium; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (SJC); Department of Epidemiology, MD Anderson Cancer Center, Houston, TX (WHC); Department of Surgery, University of Saskatchewan, Saskatoon SK, Canada (AGC); Department of Biostatistics, University of Washington School of Public Health, Seattle, WA (DML, RZ); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (WY); Division of Epidemiology, University of Leeds, Leeds, UK (LJH).
Anna H WuDivision of Public Health Sciences (APT, LO, TLV) and Division of Human Biology (BJR), Fred Hutchinson Cancer Research Center, Seattle, WA; Cancer Control Group (APT, DCW) and Statistical Genetics (WEE, SM), QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Division of Gastroenterology and Hepatology, UNC School of Medicine (NJS) and Department of Epidemiology, School of Public Health (MDG), University of North Carolina, Chapel Hill, NC; Department of Population Sciences, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, CA (LB); Yale School of Public Health, Department of Chronic Disease Epidemiology, New Haven, CT (HAR); Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre-Ontario Cancer Institute, University of Toronto, Toronto, ON, Canada (GL); Department of Oncology, The Medical School, University of Sheffield, Sheffield, UK (NCB); Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA (AHW); Division of Research and Oakland Medical Center, Kaiser Permanente, Oakland, CA (DAC); Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN (YR), on behalf of the Mayo Clinic Esophageal Adenocarcinoma and Barrett's Esophagus Registry Consortium; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (SJC); Department of Epidemiology, MD Anderson Cancer Center, Houston, TX (WHC); Department of Surgery, University of Saskatchewan, Saskatoon SK, Canada (AGC); Department of Biostatistics, University of Washington School of Public Health, Seattle, WA (DML, RZ); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (WY); Division of Epidemiology, University of Leeds, Leeds, UK (LJH).
Douglas A CorleyDivision of Public Health Sciences (APT, LO, TLV) and Division of Human Biology (BJR), Fred Hutchinson Cancer Research Center, Seattle, WA; Cancer Control Group (APT, DCW) and Statistical Genetics (WEE, SM), QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Division of Gastroenterology and Hepatology, UNC School of Medicine (NJS) and Department of Epidemiology, School of Public Health (MDG), University of North Carolina, Chapel Hill, NC; Department of Population Sciences, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, CA (LB); Yale School of Public Health, Department of Chronic Disease Epidemiology, New Haven, CT (HAR); Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre-Ontario Cancer Institute, University of Toronto, Toronto, ON, Canada (GL); Department of Oncology, The Medical School, University of Sheffield, Sheffield, UK (NCB); Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA (AHW); Division of Research and Oakland Medical Center, Kaiser Permanente, Oakland, CA (DAC); Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN (YR), on behalf of the Mayo Clinic Esophageal Adenocarcinoma and Barrett's Esophagus Registry Consortium; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (SJC); Department of Epidemiology, MD Anderson Cancer Center, Houston, TX (WHC); Department of Surgery, University of Saskatchewan, Saskatoon SK, Canada (AGC); Department of Biostatistics, University of Washington School of Public Health, Seattle, WA (DML, RZ); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (WY); Division of Epidemiology, University of Leeds, Leeds, UK (LJH).
Yvonne RomeroDivision of Public Health Sciences (APT, LO, TLV) and Division of Human Biology (BJR), Fred Hutchinson Cancer Research Center, Seattle, WA; Cancer Control Group (APT, DCW) and Statistical Genetics (WEE, SM), QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Division of Gastroenterology and Hepatology, UNC School of Medicine (NJS) and Department of Epidemiology, School of Public Health (MDG), University of North Carolina, Chapel Hill, NC; Department of Population Sciences, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, CA (LB); Yale School of Public Health, Department of Chronic Disease Epidemiology, New Haven, CT (HAR); Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre-Ontario Cancer Institute, University of Toronto, Toronto, ON, Canada (GL); Department of Oncology, The Medical School, University of Sheffield, Sheffield, UK (NCB); Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA (AHW); Division of Research and Oakland Medical Center, Kaiser Permanente, Oakland, CA (DAC); Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN (YR), on behalf of the Mayo Clinic Esophageal Adenocarcinoma and Barrett's Esophagus Registry Consortium; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (SJC); Department of Epidemiology, MD Anderson Cancer Center, Houston, TX (WHC); Department of Surgery, University of Saskatchewan, Saskatoon SK, Canada (AGC); Department of Biostatistics, University of Washington School of Public Health, Seattle, WA (DML, RZ); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (WY); Division of Epidemiology, University of Leeds, Leeds, UK (LJH).
Stephen J ChanockDivision of Public Health Sciences (APT, LO, TLV) and Division of Human Biology (BJR), Fred Hutchinson Cancer Research Center, Seattle, WA; Cancer Control Group (APT, DCW) and Statistical Genetics (WEE, SM), QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Division of Gastroenterology and Hepatology, UNC School of Medicine (NJS) and Department of Epidemiology, School of Public Health (MDG), University of North Carolina, Chapel Hill, NC; Department of Population Sciences, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, CA (LB); Yale School of Public Health, Department of Chronic Disease Epidemiology, New Haven, CT (HAR); Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre-Ontario Cancer Institute, University of Toronto, Toronto, ON, Canada (GL); Department of Oncology, The Medical School, University of Sheffield, Sheffield, UK (NCB); Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA (AHW); Division of Research and Oakland Medical Center, Kaiser Permanente, Oakland, CA (DAC); Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN (YR), on behalf of the Mayo Clinic Esophageal Adenocarcinoma and Barrett's Esophagus Registry Consortium; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (SJC); Department of Epidemiology, MD Anderson Cancer Center, Houston, TX (WHC); Department of Surgery, University of Saskatchewan, Saskatoon SK, Canada (AGC); Department of Biostatistics, University of Washington School of Public Health, Seattle, WA (DML, RZ); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (WY); Division of Epidemiology, University of Leeds, Leeds, UK (LJH).
Wong-Ho ChowDivision of Public Health Sciences (APT, LO, TLV) and Division of Human Biology (BJR), Fred Hutchinson Cancer Research Center, Seattle, WA; Cancer Control Group (APT, DCW) and Statistical Genetics (WEE, SM), QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Division of Gastroenterology and Hepatology, UNC School of Medicine (NJS) and Department of Epidemiology, School of Public Health (MDG), University of North Carolina, Chapel Hill, NC; Department of Population Sciences, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, CA (LB); Yale School of Public Health, Department of Chronic Disease Epidemiology, New Haven, CT (HAR); Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre-Ontario Cancer Institute, University of Toronto, Toronto, ON, Canada (GL); Department of Oncology, The Medical School, University of Sheffield, Sheffield, UK (NCB); Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA (AHW); Division of Research and Oakland Medical Center, Kaiser Permanente, Oakland, CA (DAC); Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN (YR), on behalf of the Mayo Clinic Esophageal Adenocarcinoma and Barrett's Esophagus Registry Consortium; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (SJC); Department of Epidemiology, MD Anderson Cancer Center, Houston, TX (WHC); Department of Surgery, University of Saskatchewan, Saskatoon SK, Canada (AGC); Department of Biostatistics, University of Washington School of Public Health, Seattle, WA (DML, RZ); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (WY); Division of Epidemiology, University of Leeds, Leeds, UK (LJH).
Alan G CassonDivision of Public Health Sciences (APT, LO, TLV) and Division of Human Biology (BJR), Fred Hutchinson Cancer Research Center, Seattle, WA; Cancer Control Group (APT, DCW) and Statistical Genetics (WEE, SM), QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Division of Gastroenterology and Hepatology, UNC School of Medicine (NJS) and Department of Epidemiology, School of Public Health (MDG), University of North Carolina, Chapel Hill, NC; Department of Population Sciences, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, CA (LB); Yale School of Public Health, Department of Chronic Disease Epidemiology, New Haven, CT (HAR); Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre-Ontario Cancer Institute, University of Toronto, Toronto, ON, Canada (GL); Department of Oncology, The Medical School, University of Sheffield, Sheffield, UK (NCB); Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA (AHW); Division of Research and Oakland Medical Center, Kaiser Permanente, Oakland, CA (DAC); Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN (YR), on behalf of the Mayo Clinic Esophageal Adenocarcinoma and Barrett's Esophagus Registry Consortium; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (SJC); Department of Epidemiology, MD Anderson Cancer Center, Houston, TX (WHC); Department of Surgery, University of Saskatchewan, Saskatoon SK, Canada (AGC); Department of Biostatistics, University of Washington School of Public Health, Seattle, WA (DML, RZ); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (WY); Division of Epidemiology, University of Leeds, Leeds, UK (LJH).
David M LevineDivision of Public Health Sciences (APT, LO, TLV) and Division of Human Biology (BJR), Fred Hutchinson Cancer Research Center, Seattle, WA; Cancer Control Group (APT, DCW) and Statistical Genetics (WEE, SM), QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Division of Gastroenterology and Hepatology, UNC School of Medicine (NJS) and Department of Epidemiology, School of Public Health (MDG), University of North Carolina, Chapel Hill, NC; Department of Population Sciences, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, CA (LB); Yale School of Public Health, Department of Chronic Disease Epidemiology, New Haven, CT (HAR); Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre-Ontario Cancer Institute, University of Toronto, Toronto, ON, Canada (GL); Department of Oncology, The Medical School, University of Sheffield, Sheffield, UK (NCB); Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA (AHW); Division of Research and Oakland Medical Center, Kaiser Permanente, Oakland, CA (DAC); Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN (YR), on behalf of the Mayo Clinic Esophageal Adenocarcinoma and Barrett's Esophagus Registry Consortium; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (SJC); Department of Epidemiology, MD Anderson Cancer Center, Houston, TX (WHC); Department of Surgery, University of Saskatchewan, Saskatoon SK, Canada (AGC); Department of Biostatistics, University of Washington School of Public Health, Seattle, WA (DML, RZ); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (WY); Division of Epidemiology, University of Leeds, Leeds, UK (LJH).
Rui ZhangDivision of Public Health Sciences (APT, LO, TLV) and Division of Human Biology (BJR), Fred Hutchinson Cancer Research Center, Seattle, WA; Cancer Control Group (APT, DCW) and Statistical Genetics (WEE, SM), QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Division of Gastroenterology and Hepatology, UNC School of Medicine (NJS) and Department of Epidemiology, School of Public Health (MDG), University of North Carolina, Chapel Hill, NC; Department of Population Sciences, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, CA (LB); Yale School of Public Health, Department of Chronic Disease Epidemiology, New Haven, CT (HAR); Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre-Ontario Cancer Institute, University of Toronto, Toronto, ON, Canada (GL); Department of Oncology, The Medical School, University of Sheffield, Sheffield, UK (NCB); Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA (AHW); Division of Research and Oakland Medical Center, Kaiser Permanente, Oakland, CA (DAC); Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN (YR), on behalf of the Mayo Clinic Esophageal Adenocarcinoma and Barrett's Esophagus Registry Consortium; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (SJC); Department of Epidemiology, MD Anderson Cancer Center, Houston, TX (WHC); Department of Surgery, University of Saskatchewan, Saskatoon SK, Canada (AGC); Department of Biostatistics, University of Washington School of Public Health, Seattle, WA (DML, RZ); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (WY); Division of Epidemiology, University of Leeds, Leeds, UK (LJH).
Weronica E EkDivision of Public Health Sciences (APT, LO, TLV) and Division of Human Biology (BJR), Fred Hutchinson Cancer Research Center, Seattle, WA; Cancer Control Group (APT, DCW) and Statistical Genetics (WEE, SM), QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Division of Gastroenterology and Hepatology, UNC School of Medicine (NJS) and Department of Epidemiology, School of Public Health (MDG), University of North Carolina, Chapel Hill, NC; Department of Population Sciences, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, CA (LB); Yale School of Public Health, Department of Chronic Disease Epidemiology, New Haven, CT (HAR); Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre-Ontario Cancer Institute, University of Toronto, Toronto, ON, Canada (GL); Department of Oncology, The Medical School, University of Sheffield, Sheffield, UK (NCB); Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA (AHW); Division of Research and Oakland Medical Center, Kaiser Permanente, Oakland, CA (DAC); Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN (YR), on behalf of the Mayo Clinic Esophageal Adenocarcinoma and Barrett's Esophagus Registry Consortium; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (SJC); Department of Epidemiology, MD Anderson Cancer Center, Houston, TX (WHC); Department of Surgery, University of Saskatchewan, Saskatoon SK, Canada (AGC); Department of Biostatistics, University of Washington School of Public Health, Seattle, WA (DML, RZ); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (WY); Division of Epidemiology, University of Leeds, Leeds, UK (LJH).
Stuart MacGregorDivision of Public Health Sciences (APT, LO, TLV) and Division of Human Biology (BJR), Fred Hutchinson Cancer Research Center, Seattle, WA; Cancer Control Group (APT, DCW) and Statistical Genetics (WEE, SM), QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Division of Gastroenterology and Hepatology, UNC School of Medicine (NJS) and Department of Epidemiology, School of Public Health (MDG), University of North Carolina, Chapel Hill, NC; Department of Population Sciences, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, CA (LB); Yale School of Public Health, Department of Chronic Disease Epidemiology, New Haven, CT (HAR); Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre-Ontario Cancer Institute, University of Toronto, Toronto, ON, Canada (GL); Department of Oncology, The Medical School, University of Sheffield, Sheffield, UK (NCB); Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA (AHW); Division of Research and Oakland Medical Center, Kaiser Permanente, Oakland, CA (DAC); Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN (YR), on behalf of the Mayo Clinic Esophageal Adenocarcinoma and Barrett's Esophagus Registry Consortium; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (SJC); Department of Epidemiology, MD Anderson Cancer Center, Houston, TX (WHC); Department of Surgery, University of Saskatchewan, Saskatoon SK, Canada (AGC); Department of Biostatistics, University of Washington School of Public Health, Seattle, WA (DML, RZ); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (WY); Division of Epidemiology, University of Leeds, Leeds, UK (LJH).
Weimin YeDivision of Public Health Sciences (APT, LO, TLV) and Division of Human Biology (BJR), Fred Hutchinson Cancer Research Center, Seattle, WA; Cancer Control Group (APT, DCW) and Statistical Genetics (WEE, SM), QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Division of Gastroenterology and Hepatology, UNC School of Medicine (NJS) and Department of Epidemiology, School of Public Health (MDG), University of North Carolina, Chapel Hill, NC; Department of Population Sciences, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, CA (LB); Yale School of Public Health, Department of Chronic Disease Epidemiology, New Haven, CT (HAR); Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre-Ontario Cancer Institute, University of Toronto, Toronto, ON, Canada (GL); Department of Oncology, The Medical School, University of Sheffield, Sheffield, UK (NCB); Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA (AHW); Division of Research and Oakland Medical Center, Kaiser Permanente, Oakland, CA (DAC); Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN (YR), on behalf of the Mayo Clinic Esophageal Adenocarcinoma and Barrett's Esophagus Registry Consortium; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (SJC); Department of Epidemiology, MD Anderson Cancer Center, Houston, TX (WHC); Department of Surgery, University of Saskatchewan, Saskatoon SK, Canada (AGC); Department of Biostatistics, University of Washington School of Public Health, Seattle, WA (DML, RZ); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (WY); Division of Epidemiology, University of Leeds, Leeds, UK (LJH).
Laura J HardieDivision of Public Health Sciences (APT, LO, TLV) and Division of Human Biology (BJR), Fred Hutchinson Cancer Research Center, Seattle, WA; Cancer Control Group (APT, DCW) and Statistical Genetics (WEE, SM), QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Division of Gastroenterology and Hepatology, UNC School of Medicine (NJS) and Department of Epidemiology, School of Public Health (MDG), University of North Carolina, Chapel Hill, NC; Department of Population Sciences, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, CA (LB); Yale School of Public Health, Department of Chronic Disease Epidemiology, New Haven, CT (HAR); Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre-Ontario Cancer Institute, University of Toronto, Toronto, ON, Canada (GL); Department of Oncology, The Medical School, University of Sheffield, Sheffield, UK (NCB); Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA (AHW); Division of Research and Oakland Medical Center, Kaiser Permanente, Oakland, CA (DAC); Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN (YR), on behalf of the Mayo Clinic Esophageal Adenocarcinoma and Barrett's Esophagus Registry Consortium; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (SJC); Department of Epidemiology, MD Anderson Cancer Center, Houston, TX (WHC); Department of Surgery, University of Saskatchewan, Saskatoon SK, Canada (AGC); Department of Biostatistics, University of Washington School of Public Health, Seattle, WA (DML, RZ); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (WY); Division of Epidemiology, University of Leeds, Leeds, UK (LJH).
Thomas L VaughanDivision of Public Health Sciences (APT, LO, TLV) and Division of Human Biology (BJR), Fred Hutchinson Cancer Research Center, Seattle, WA; Cancer Control Group (APT, DCW) and Statistical Genetics (WEE, SM), QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Division of Gastroenterology and Hepatology, UNC School of Medicine (NJS) and Department of Epidemiology, School of Public Health (MDG), University of North Carolina, Chapel Hill, NC; Department of Population Sciences, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, CA (LB); Yale School of Public Health, Department of Chronic Disease Epidemiology, New Haven, CT (HAR); Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre-Ontario Cancer Institute, University of Toronto, Toronto, ON, Canada (GL); Department of Oncology, The Medical School, University of Sheffield, Sheffield, UK (NCB); Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA (AHW); Division of Research and Oakland Medical Center, Kaiser Permanente, Oakland, CA (DAC); Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN (YR), on behalf of the Mayo Clinic Esophageal Adenocarcinoma and Barrett's Esophagus Registry Consortium; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (SJC); Department of Epidemiology, MD Anderson Cancer Center, Houston, TX (WHC); Department of Surgery, University of Saskatchewan, Saskatoon SK, Canada (AGC); Department of Biostatistics, University of Washington School of Public Health, Seattle, WA (DML, RZ); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (WY); Division of Epidemiology, University of Leeds, Leeds, UK (LJH).
David C WhitemanDivision of Public Health Sciences (APT, LO, TLV) and Division of Human Biology (BJR), Fred Hutchinson Cancer Research Center, Seattle, WA; Cancer Control Group (APT, DCW) and Statistical Genetics (WEE, SM), QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Division of Gastroenterology and Hepatology, UNC School of Medicine (NJS) and Department of Epidemiology, School of Public Health (MDG), University of North Carolina, Chapel Hill, NC; Department of Population Sciences, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, CA (LB); Yale School of Public Health, Department of Chronic Disease Epidemiology, New Haven, CT (HAR); Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre-Ontario Cancer Institute, University of Toronto, Toronto, ON, Canada (GL); Department of Oncology, The Medical School, University of Sheffield, Sheffield, UK (NCB); Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA (AHW); Division of Research and Oakland Medical Center, Kaiser Permanente, Oakland, CA (DAC); Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN (YR), on behalf of the Mayo Clinic Esophageal Adenocarcinoma and Barrett's Esophagus Registry Consortium; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (SJC); Department of Epidemiology, MD Anderson Cancer Center, Houston, TX (WHC); Department of Surgery, University of Saskatchewan, Saskatoon SK, Canada (AGC); Department of Biostatistics, University of Washington School of Public Health, Seattle, WA (DML, RZ); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (WY); Division of Epidemiology, University of Leeds, Leeds, UK (LJH).
QIMR Berghofer Medical Research Institute · AUCape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa · ZADivision of Cancer Epidemiology and GeneticsFred Hutch Cancer Center · USKarolinska Institutet · SEMayo Clinic in Arizona · USUniversity of Leeds · GBUniversity of Saskatchewan · CAUniversity of Washington · USYale University · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
PHYLOGENIES of Barrett's Esophagus LineagesP01CA091955 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI GRADY, WILLIAM MALLORY · 2002 to 2019
$35.9M
PILOT AND FEASIBILITY STUDIESP30DK034987 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROBERT S. SANDLER · 1985 to 2026
$30.5M
UT M.D. Anderson Cancer Center SPORE in MelanomaP50CA093459 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI GRIMM, ELIZABETH A · 2004 to 2014
$23.7M
Barrett's and Esophageal Adenocarcinoma Genetic Susceptibility Study (BEAGESS)R01CA136725 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI VAUGHAN, THOMAS L, WHITEMAN, DAVID C · 2009 to 2011
$7.8M
Epidemiology and Incidence of Barrett's EsophagusR01DK063616 · NIDDK · KAISER FOUNDATION RESEARCH INSTITUTE · PI CORLEY, DOUGLAS ALLEN · 2002 to 2010
$2.6M
ESTABLISHED INVESTIGATOR AWARD IN CANCER PREVENTION AND CONTROLK05CA124911 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI VAUGHAN, THOMAS L · 2007 to 2016
$1.6M
Genetic Predictors for DNA Repair Phenotype in CMMR01CA100264 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI WEI, QINGYI · 2004 to 2008
$1.5M
Statistical Methods for Gene Environment Interactions In Lung CancerR01CA133996 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI AMOS, CHRISTOPHER I. · 2007 to 2009
$790k
EPIDEMIOLOGY OF BARRETTS ESOPHAGUSR01CA072866 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI VAUGHAN, THOMAS L · 1997 to 2000
$543k
ETIOLOGY OF GASTRIC CARDIA/ESOPHAGEAL ADENOCARCINOMAR01CA059636 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BERNSTEIN, LESLIE · 1993 to 1997
–
RISK FACTORS FOR CANCER--ESOPHAGUS AND GASTRIC CARDIAR01CA057947 · NCI · UPPSALA UNIVERSITY · PI ADAMI, HANS-OLOV · 1994 to 1996
–
NCI NIH HHS K05 CA124911NCI NIH HHS K05CA124911NCI NIH HHS P01 CA091955NCI NIH HHS P01CA091955NCI NIH HHS P30CA016672NCI NIH HHS P50CA093459NCI NIH HHS R01 CA072866NCI NIH HHS R01CA072866NCI NIH HHS R01CA100264NCI NIH HHS R01CA133996NCI NIH HHS R01 CA136725NCI NIH HHS R01CA136725NCI NIH HHS R01CA57947NCI NIH HHS R01CA59636NCI NIH HHS U01 CA057949NCI NIH HHS U01CA57923NCI NIH HHS U01CA57949NCI NIH HHS U01CA57983NIDDK NIH HHS P30 DK034987NIDDK NIH HHS R01DK63616PHS HHS NIDDK 02956
6 · The paper itself

Abstract

backgroundData from observational studies suggest that body mass index (BMI) is causally related to esophageal adenocarcinoma (EAC) and its precursor, Barrett's esophagus (BE). However, the relationships may be affected by bias and confounding.

methodsWe used data from the Barrett's and Esophageal Adenocarcinoma Genetic Susceptibility Study: 999 patients with EAC, 2061 patients with BE, and 2169 population controls. We applied the two-stage control function instrumental variable method of the Mendelian randomization approach to estimate the unbiased, unconfounded effect of BMI on risk of EAC and BE. This was performed using a genetic risk score, derived from 29 genetic variants shown to be associated with BMI, as an instrument for lifetime BMI. A higher score indicates propensity to obesity. All tests were two-sided.

resultsThe genetic risk score was not associated with potential confounders, including gastroesophageal reflux symptoms and smoking. In the instrumental variable analyses (IV), EAC risk increased by 16% (IV-odds ratio [OR] = 1.16, 95% confidence interval [CI] = 1.01 to 1.33) and BE risk increased by 12% (IV-OR = 1.12, 95% CI = 1.00 to 1.25) per 1kg/m(2) increase in BMI. BMI was statistically significantly associated with EAC and BE in conventional epidemiologic analyses.

conclusionsPeople with a high genetic propensity to obesity have higher risks of esophageal metaplasia and neoplasia than people with low genetic propensity. These analyses provide the strongest evidence to date that obesity is independently associated with BE and EAC, and is not due to confounding or bias inherent in conventional epidemiologic analyses.

Indexed as

Body Mass IndexMendelian Randomization AnalysisPolymorphism, Single NucleotideAdenocarcinomaAdultAgedBarrett EsophagusEsophageal NeoplasmsFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMiddle AgedObesityPrecancerous Conditions

Identifiers

PMID25269698
PMCPMC4200028
OpenAlexW2060066452

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.