ReviewCurrent allergy and asthma reports2014
The expanding spectrum of human coronin 1A deficiency.
Review in Current allergy and asthma reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 20 citations in OpenAlex.
- A Novel Variant of CORO1A Gene Contributing to the Development of Primary Immunodeficiency in Children.Case reports in immunology · 2026Article
- The tryptophan-aspartate (WD) repeat domain of bovine Coronin-1A promotes mycobacterial survival by inhibiting calcium signaling-mediated phagosome-lysosome fusion.Veterinary research · 2025Article
- Novel hemizygousThe journal of allergy and clinical immunology. Global · 2024Article
- Inherited immunodeficiencies associated with proximal and distal defects in T cell receptor signaling and co-signaling.Biomedical journal · 2022Review
- Inherited Immunodeficiencies With High Predisposition to Epstein-Barr Virus-Driven Lymphoproliferative Diseases.Frontiers in immunology · 2018Review
- Beta and Gamma Human Herpesviruses: Agonistic and Antagonistic Interactions with the Host Immune System.Frontiers in microbiology · 2017Review
- Emergent Role of Coronin-1a in Neuronal Signaling.Vitamins and hormones · 2017Review
- Coronin-1A: immune deficiency in humans and mice.Journal of clinical immunology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since the first discovery of coronin in the amoeba Dictyostelium discoideum, remarkable insights have been gained regarding the structure and function of coronins, highly conserved from yeast to humans. It has been speculated that coronins have evolved from actin-binding molecules in lower eukaryotes to regulators of various cellular processes in mammals. Indeed, coronins are not only involved in cytokinesis, cell motility, and other actin-related processes but they are also implicated in immune homeostasis and calcium-calcineurin signaling. Most strikingly, coronin 1 deficiencies give rise to immune deficiencies in mice and humans that are characterized by severe T lymphocytopenia. Whereas complete absence of coronin 1A is associated with severe combined immunodeficiency in humans, hypomorphic mutations lead to a profound defect in naïve T cells, expansion of oligoclonal memory T cells, and exquisite susceptibility to EBV-associated B cell lymphoproliferation. Recent publications show that coronin 1A also plays a role in natural killer cell cytotoxic function and in neurobehavioral processes. It can be expected that future identification of coronin 1A-deficient patients will further extend the phenotypic spectrum thereby increasing our knowledge of this fascinating molecule.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.