Evidence map›Paper›PMID 25268971›Full record

ArticlePloS one2014

Chimeric NP non coding regions between type A and C influenza viruses reveal their role in translation regulation.

Bernadette Crescenzo-Chaigne, Cyril Barbezange, Vianney Frigard, Damien Poulain, Sylvie van der Werf

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Bernadette Crescenzo-ChaigneUnité de Génétique Moléculaire des Virus à ARN, Institut Pasteur, Paris, France; Unité Mixte de Recherche 3569, Centre National de la Recherche Scientifique, Paris, France.
Cyril BarbezangeUnité de Génétique Moléculaire des Virus à ARN, Institut Pasteur, Paris, France; Unité Mixte de Recherche 3569, Centre National de la Recherche Scientifique, Paris, France.
Vianney FrigardUnité de Génétique Moléculaire des Virus à ARN, Institut Pasteur, Paris, France; Unité Mixte de Recherche 3569, Centre National de la Recherche Scientifique, Paris, France.
Damien PoulainUnité de Génétique Moléculaire des Virus à ARN, Institut Pasteur, Paris, France; Unité Mixte de Recherche 3569, Centre National de la Recherche Scientifique, Paris, France.
Sylvie van der WerfUnité de Génétique Moléculaire des Virus à ARN, Institut Pasteur, Paris, France; Unité Mixte de Recherche 3569, Centre National de la Recherche Scientifique, Paris, France; Université Paris Diderot Sorbonne Paris Cité, Paris, France.
Institut Pasteur · FRUniversité Paris Cité · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exchange of the non coding regions of the NP segment between type A and C influenza viruses was used to demonstrate the importance not only of the proximal panhandle, but also of the initial distal panhandle strength in type specificity. Both elements were found to be compulsory to rescue infectious virus by reverse genetics systems. Interestingly, in type A influenza virus infectious context, the length of the NP segment 5' NC region once transcribed into mRNA was found to impact its translation, and the level of produced NP protein consequently affected the level of viral genome replication.

Indexed as

Gene Expression Regulation, ViralProtein BiosynthesisAnimalsBase SequenceDogsGammainfluenzavirusInfluenza A virusMadin Darby Canine Kidney CellsMolecular Sequence DataMutagenesis, Site-DirectedMutant Chimeric ProteinsNucleocapsid ProteinsReverse GeneticsRNA-Binding ProteinsRNA, MessengerRNA, ViralMutant Chimeric ProteinsNP protein, Influenza A virusNucleocapsid ProteinsRNA-Binding ProteinsRNA, MessengerRNA, ViralViral Core Proteins

Identifiers

PMID25268971
PMCPMC4182659
OpenAlexW2083306446

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.