Evidence map›Paper›PMID 25268903›Full record

ArticlePloS one2014

Retention and risk factors for attrition in a large public health ART program in Myanmar: a retrospective cohort analysis.

Aye Thida, Sai Thein Than Tun, Sai Ko Ko Zaw, Andrew A Lover, Philippe Cavailler, Jennifer Chunn, Mar Mar Aye, Par Par, Kyaw Win Naing, Kaung Nyunt Zan and 4 more

Abstract read
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Aye ThidaThe Union Office in Myanmar, International Union Against Tuberculosis and Lung Disease, Mandalay, Myanmar.
Sai Thein Than TunThe Union Office in Myanmar, International Union Against Tuberculosis and Lung Disease, Mandalay, Myanmar.
Sai Ko Ko ZawThe Union Office in Myanmar, International Union Against Tuberculosis and Lung Disease, Mandalay, Myanmar.
Andrew A LoverInfectious Diseases Programme, Saw Swee Hock School of Public Health, National University of Singapore, Singapore.
Philippe CavaillerInnovation Unit, Médecins Sans Frontières, Geneva, Switzerland.
Jennifer ChunnMaths and Statistics Help Centre, James Cook University, Singapore.
Mar Mar AyeMedical Care Division, Department of Health, Mandalay, Myanmar.
Par ParMedical Care Division, Department of Health, Mandalay, Myanmar.
Kyaw Win NaingMedical Care Division, Department of Health, Mandalay, Myanmar.
Kaung Nyunt ZanMedical Care Division, Department of Health, Mandalay, Myanmar.
Myint ShweNational AIDS Program, Department of Health, Nay Pyi Taw, Myanmar.
Thar Tun KyawDisease Control Division, Department of Health, Nay Pyi Taw, Myanmar.
Zaw Htoon WaingThe Union Office in Myanmar, International Union Against Tuberculosis and Lung Disease, Mandalay, Myanmar.
Philippe ClevenberghThe Union Office in Myanmar, International Union Against Tuberculosis and Lung Disease, Mandalay, Myanmar.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe outcomes from an antiretroviral treatment (ART) program within the public sector in Myanmar have not been reported. This study documents retention and the risk factors for attrition in a large ART public health program in Myanmar.

methodsA retrospective analysis of a cohort of adult patients enrolled in the Integrated HIV Care (IHC) Program between June 2005 and October 2011 and followed up until April 2012 is presented. The primary outcome was attrition (death or loss-follow up); a total of 10,223 patients were included in the 5-year cumulative survival analysis. Overall 5,718 patients were analyzed for the risk factors for attrition using both logistic regression and flexible parametric survival models.

resultThe mean age was 36 years, 61% of patients were male, and the median follow up was 13.7 months. Overall 8,564 (84%) patients were retained in ART program: 750 (7%) were lost to follow-up and 909 (9%) died. During the 3 years follow-up, 1,542 attritions occurred over 17,524 person years at risk, giving an incidence density of 8.8% per year. The retention rates of participants at 12, 24, 36, 48 and 60 months were 86, 82, 80, 77 and 74% respectively. In multivariate analysis, being male, having high WHO staging, a low CD4 count, being anaemic or having low BMI at baseline were independent risk factors for attrition; tuberculosis (TB) treatment at ART initiation, a prior ART course before program enrollment and literacy were predictors for retention in the program.

conclusionHigh retention rate of IHC program was documented within the public sector in Myanmar. Early diagnosis of HIV, nutritional support, proper investigation and treatment for patients with low CD4 counts and for those presenting with anaemia are crucial issues towards improvement of HIV program outcomes in resource-limited settings.

Indexed as

Drug MonitoringLost to Follow-UpAdultAnti-HIV AgentsCD4 Lymphocyte CountFemaleHIV InfectionsHumansMaleMedication AdherenceMyanmarNational Health ProgramsPatient CompliancePublic HealthRetrospective StudiesRisk FactorsAnti-HIV Agents

Identifiers

PMID25268903
PMCPMC4182661

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.