Evidence map›Paper›PMID 25268791›Full record

SynthesisPloS one2014

Clinical effectiveness of protein and amino acid supplementation on building muscle mass in elderly people: a meta-analysis.

Zhe-rong Xu, Zhong-ju Tan, Qin Zhang, Qi-feng Gui, Yun-mei Yang

Registry-linked trialOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02912130 (The Multidimensional Effects of Exercise and Nutritional Interventions on Musculoskeletal Functioning, Nutritional Status and Quality of Life in Age-related Sarcopenia), which is not on this map. Cited by 30 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 5 pooled it
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02912130 nacompletednot on this mapstarted 2016, after this paper: background citation

The Multidimensional Effects of Exercise and Nutritional Interventions on Musculoskeletal Functioning, Nutritional Status and Quality of Life in Age-related Sarcopenia

TypeinterventionalSponsorLiverpool Hope UniversityRan2016 to 2023Enrolled110ConditionsSarcopenia, Muscular AtrophyArmsProtein Supplementation, Aerobic Exercise, Resistance Exercise
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 5 syntheses or guidelines pooled it, 55 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Zhe-rong XuDepartment of Geriatrics, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Zhong-ju TanDepartment of Geriatrics, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Qin ZhangDepartment of Geriatrics, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Qi-feng GuiDepartment of Geriatrics, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Yun-mei YangState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Department of Geriatrics, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Zhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveA major reason for the loss of mobility in elderly people is the gradual loss of lean body mass known as sarcopenia. Sarcopenia is associated with a lower quality of life and higher healthcare costs. The benefit of strategies that include nutritional intervention, timing of intervention, and physical exercise to improve muscle loss unclear as finding from studies investigating this issue have been inconsistent. We have performed a systematic review and meta-analysis to assess the ability of protein or amino acid supplementation to augment lean body mass or strength of leg muscles in elderly patients.

methodsNine studies met the inclusion criteria of being a prospective comparative study or randomized controlled trial (RCT) that compared the efficacy of an amino acid or protein supplement intervention with that of a placebo in elderly people (≥ 65 years) for the improvement of lean body mass (LBM), leg muscle strength or reduction associated with sarcopenia.

resultsThe overall difference in mean change from baseline to the end of study in LBM between the treatment and placebo groups was 0.34 kg which was not significant (P = 0.386). The overall differences in mean change from baseline in double leg press and leg extension were 2.14 kg (P = 0.748) and 2.28 kg (P = 0.265), respectively, between the treatment group and the placebo group.

conclusionsThese results indicate that amino acid/protein supplements did not increase lean body mass gain and muscle strength significantly more than placebo in a diverse elderly population.

Indexed as

Dietary SupplementsAgedAged, 80 and overAmino AcidsBody CompositionDietary ProteinsExerciseFemaleFrail ElderlyHumansMaleMuscle, SkeletalMuscle StrengthSarcopeniaTreatment OutcomeAmino AcidsDietary Proteins

Identifiers

PMID25268791
PMCPMC4182521
OpenAlexW1971281209

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.