ArticleJournal of psychiatry & neuroscience : JPN2015
Increased orbitofrontal cortex activation associated with "pro-obsessive" antipsychotic treatment in patients with schizophrenia.
Article in Journal of psychiatry & neuroscience : JPN, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Modulation of hemispheric asymmetry in executive control of attention in schizophrenia with atypical antipsychotic treatment: Potential benefits of olanzapine.Schizophrenia research. Cognition · 2024Article
- The role of psychosis and clozapine load in excessive checking in treatment-resistant schizophrenia: longitudinal observational study.The British journal of psychiatry : the journal of mental science · 2024Observational
- The Neurobiological Underpinnings of Obsessive-Compulsive Symptoms in Psychosis, Translational Issues for Treatment-Resistant Schizophrenia.Biomolecules · 2023Review
- Different degrees of nodes behind obsessive-compulsive symptoms of schizophrenia.Frontiers in psychiatry · 2023Article
- [Obsessive-compulsive symptoms in psychotic disorders: pathogenesis and treatment].Der Nervenarzt · 2022Review
- The Relationships Between Obsessive-Compulsive Disorder and Psychosis: An Unresolved Issue.Clinical neuropsychiatry · 2020Article
- Reduced activity and connectivity of left amygdala in patients with schizophrenia treated with clozapine or olanzapine.European archives of psychiatry and clinical neuroscience · 2019Article
- A cross sectional study of impact and clinical risk factors of antipsychotic-induced OCD.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2019Article
- Longitudinal association between motor and obsessive compulsive symptoms in patients with psychosis and their unaffected siblings.European archives of psychiatry and clinical neuroscience · 2019Article
- Obsessive-compulsive disorder comorbid with schizophrenia and bipolar disorder.Indian journal of psychiatry · 2019Review
- Altered Functional Connectivity of the Default Mode Network in Patients With Schizo-obsessive Comorbidity: A Comparison Between Schizophrenia and Obsessive-compulsive Disorder.Schizophrenia bulletin · 2019Article
- Psychopharmacological Treatment of Obsessive-Compulsive Disorder (OCD).Current neuropharmacology · 2019Review
- Clozapine-induced obsessive–compulsive symptoms: mechanisms and treatmentJournal of psychiatry & neuroscience : JPN · 2019Article
- Distinct risk factors for obsessive and compulsive symptoms in chronic schizophrenia.Psychological medicine · 2018Article
- Psychosis or Obsessions? Clozapine Associated with Worsening Obsessive-Compulsive Symptoms.Case reports in psychiatry · 2016Article
- Comorbid Obsessive-Compulsive Symptoms in Schizophrenia: Insight into Pathomechanisms Facilitates Treatment.Advances in medicine · 2014Review
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with schizophrenia have an approximately 10-fold higher risk for obsessive-compulsive symptoms (OCS) than the general population. A large subgroup seems to experience OCS as a consequence of second-generation antipsychotic agents (SGA), such as clozapine. So far little is known about underlying neural mechanisms.
methodsTo investigate the role of SGA treatment on neural processing related to OCS in patients with schizophrenia, we stratified patients according to their monotherapy into 2 groups (group I: clozapine or olanzapine; group II: amisulpride or aripiprazole). We used an fMRI approach, applying a go/no-go task assessing inhibitory control and an n-back task measuring working memory.
resultsWe enrolled 21 patients in group I and 19 patients in group II. Groups did not differ regarding age, sex, education or severity of psychotic symptoms. Frequency and severity of OCS were significantly higher in group I and were associated with pronounced deficits in specific cognitive abilities. Whereas brain activation patterns did not differ during working memory, group I showed significantly increased activation in the orbitofrontal cortex (OFC) during response inhibition. Alterations in OFC activation were associated with the severity of obsessions and mediated the association between SGA treatment and co-occurring OCS on a trend level. LIMITATIONS: The main limitation of this study is its cross-sectional design.
conclusionTo our knowledge, this is the first imaging study conducted to elucidate SGA effects on neural systems related to OCS. We propose that alterations in brain functioning reflect a pathogenic mechanism in the development of SGA-induced OCS in patients with schizophrenia. Longitudinal studies and randomized interventions are needed to prove the suggested causal interrelations.
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