ArticlePloS one2014
Expression of XPG protein in the development, progression and prognosis of gastric cancer.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- The global prevalence of gastric cancer in Helicobacter pylori-infected individuals: a systematic review and meta-analysis.BMC infectious diseases · 2023Pooled it
- XPG in the Nucleotide Excision Repair and Beyond: a study on the different functional aspects of XPG and its associated diseases.Molecular biology reports · 2022Review
- XPF expression and its relationship with the risk and prognosis of colorectal cancer.Cancer cell international · 2021Article
- Interleukin 20 receptor A expression in colorectal cancer and its clinical significance.PeerJ · 2021Article
- Article
- XPG is Modulated by miR-4715-3p and rs873601 Genotypes in Lung Cancer.Cancer management and research · 2021Article
- DNA repair and cell synthesis proteins: immunohistochemical expression and correlation with recurrence-regrowth in meningiomas.Journal of molecular histology · 2020Article
- Recent advances in gastric cancer early diagnosis.World journal of gastroenterology · 2019Review
- Expression of DDB2 Protein in the Initiation, Progression, and Prognosis of Colorectal Cancer.Digestive diseases and sciences · 2018Article
- Molecular Mechanisms ofInternational journal of molecular sciences · 2018Review
- Correlation between negative expression of pepsinogen C and a series of phenotypic markers of gastric cancer in different gastric diseases.Cancer medicine · 2018Article
- DNA repair protein XPA is differentially expressed in colorectal cancer and predicts better prognosis.Cancer medicine · 2018Article
- Silencing ELMO3 Inhibits the Growth, Invasion, and Metastasis of Gastric Cancer.BioMed research international · 2018Article
- HpSlyD inducing CDX2 and VIL1 expression mediated through TCTP protein may contribute to intestinal metaplasia in the stomach.Scientific reports · 2017Article
- Article
- Recent advances in the molecular diagnostics of gastric cancer.World journal of gastroenterology · 2015Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundXeroderma pigmentosum group G (XPG) plays a critical role in preventing cells from oxidative DNA damage. This study aimed to investigate XPG protein expression in different gastric tissues and in patients with diverse prognoses, thus providing insights into its role in the development, progression and prognosis of gastric cancer (GC).
methodsA total of 176 GC, 131 adjacent non-tumour tissues, 53 atrophic gastritis (AG) and 49 superficial gastritis (SG) samples were included. Immunohistochemical staining was used to detect XPG protein expression.
resultsXPG expression was significantly higher in GC tissues compared with adjacent non-tumour tissues. In the progressive disease sequence SG→AG→GC, XPG expression was significantly higher in AG and GC compared with SG. Analysis of clinicopathological parameters and survival in GC patients demonstrated a significant association between XPG expression level and depth of tumour invasion, macroscopic type, Lauren's classification, smoking, Helicobacter pylori infection and family history. Cox multivariate survival analysis indicated that patients with positive XPG expression had significantly longer overall survival (P = 0.020, HR = 0.394, 95%CI 0.179-0.866), especially in aged younger than 60 years (P = 0.027, HR = 0.361, 95%CI 0.147-0.888) and male patients (P = 0.002, HR = 0.209, 95%CI 0.077-0.571).
conclusionsThis study demonstrated that XPG protein expression was related to the development, progression and prognosis of GC, and might thus serve as a potential biomarker for its diagnosis and prognosis.
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