Evidence map›Paper›PMID 25268651›Full record

ReviewJournal of molecular and cellular cardiology2015

The mitochondrial permeability transition pore: molecular nature and role as a target in cardioprotection.

Paolo Bernardi, Fabio Di Lisa

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of molecular and cellular cardiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 258 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
258citing papers in PubMed, 1 pooled it
17.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

258 citing papers in PubMed, 1 synthesis or guideline pooled it, 479 citations in OpenAlex.

  1. Guideline
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  9. Article
  10. Association Between Myocardial Dysfunction and Septic Shock.International journal of molecular sciences · 2026
    Review
  11. A perspective on the future of heart failure research.Journal of molecular and cellular cardiology plus · 2026
    Article
  12. Review
  13. Article
  14. Review
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  17. Article
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198 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Paolo BernardiDepartment of Biomedical Sciences, University of Padova, 35121 Padova, Italy; Consiglio Nazionale delle Ricerche Neuroscience Institute, University of Padova, 35121 Padova, Italy. Electronic address: bernardi@bio.unipd.it.
Fabio Di LisaDepartment of Biomedical Sciences, University of Padova, 35121 Padova, Italy; Consiglio Nazionale delle Ricerche Neuroscience Institute, University of Padova, 35121 Padova, Italy. Electronic address: dilisa@bio.unipd.it.
Neuroscience Institute · ITUniversity of Padua · IT

Funding

Molecular Structure and Regulation of the Permeability Transition PoreR01GM069883 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI FORTE, MICHAEL A · 2004 to 2016
$3.3M
Small Molecules Targeting the Mitochondrial Permeability TransitionR03DA033978 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI BOURDETTE, DENNIS NEIL, FORTE, MICHAEL A · 2012 to 2013
$62k
NIDA NIH HHS R03 DA033978NIDA NIH HHS R03DA033978-01NIGMS NIH HHS R01 GM069883NIGMS NIH HHS R01GM069883Telethon GGP11082Telethon GPP10005
6 · The paper itself

Abstract

The mitochondrial permeability transition (PT) - an abrupt increase permeability of the inner membrane to solutes - is a causative event in ischemia-reperfusion injury of the heart, and the focus of intense research in cardioprotection. The PT is due to opening of the PT pore (PTP), a high conductance channel that is critically regulated by a variety of pathophysiological effectors. Very recent work indicates that the PTP forms from the F-ATP synthase, which would switch from an energy-conserving to an energy-dissipating device. This review provides an update on the current debate on how this transition is achieved, and on the PTP as a target for therapeutic intervention. This article is part of a Special Issue entitled "Mitochondria: from basic mitochondrial biology to cardiovascular disease".

Indexed as

AnimalsCardiotonic AgentsCyclophilinsCyclosporineHumansMitochondria, HeartMitochondrial MembranesMitochondrial Membrane Transport ProteinsMitochondrial Permeability Transition PoreMitochondrial Proton-Translocating ATPasesPeptidyl-Prolyl Isomerase FPermeabilityCardiotonic AgentsCyclophilinsCyclosporineMitochondrial Membrane Transport ProteinsMitochondrial Permeability Transition PoreMitochondrial Proton-Translocating ATPasesPeptidyl-Prolyl Isomerase FIschemia–reperfusion injuryMitochondriaPermeability transition pore

Identifiers

PMID25268651
PMCPMC4294587
OpenAlexW2008235034

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.