ArticlePloS one2014
The apolipoprotein E polymorphism rs7412 associates with body fatness independently of plasma lipids in middle aged men.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Apolipoprotein E (APOE) genotype-associated disease risks: a phenome-wide, registry-based, case-control study utilising the UK Biobank.EBioMedicine · 2020Pooled it
- Review
- High-fat Western diet induces retinal and metabolic alterations in APOE3 and APOE4 knock-in mice.Scientific reports · 2026Article
- Association between apolipoprotein E gene polymorphisms and the effects of high-intensity interval training on body composition in university students.Frontiers in nutrition · 2026Article
- Long-term Dietary Fat Intervention Affects Retinal Health in APOE Mice.bioRxiv : the preprint server for biology · 2025Article
- Exploring the relationship between APOEε4 allele and gut microbiota composition and function in healthy adults.AMB Express · 2025Article
- Article
- Proteome-wide association studies for blood lipids and comparison with transcriptome-wide association studies.HGG advances · 2025Article
- Insights into the roles of Apolipoprotein E in adipocyte biology and obesity.International journal of obesity (2005) · 2024Review
- APOE ε4 carriage associates with improved myocardial performance from adolescence to older age.BMC cardiovascular disorders · 2024Article
- How are APOE4, changes in body weight, and longevity related? Insights from a causal mediation analysis.Frontiers in aging · 2024Article
- Neuroinflammation: A Modifiable Pathway Linking Obesity, Alzheimer's disease, and Depression.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2023Review
- Predictive link between systemic metabolism and cytokine signatures in the brain of apolipoprotein E ε4 mice.Neurobiology of aging · 2023Article
- Sex Differences in Cognition Across Aging.Current topics in behavioral neurosciences · 2023Review
- Article
- Frequencies of variants in genes associated with dyslipidemias identified in Costa Rican genomes.Frontiers in genetics · 2023Article
- Apolipoprotein E in Cardiometabolic and Neurological Health and Diseases.International journal of molecular sciences · 2022Review
- Association betweenInternational journal of molecular sciences · 2022Article
- Mediation of the APOE associations with Alzheimer's and coronary heart diseases through body mass index and lipids.GeroScience · 2022Article
- APOE ε4, Alzheimer's disease neuropathology and sleep disturbance, in individuals with and without dementia.Alzheimer's research & therapy · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe apolipoprotein E (APOE) gene is polymorphic, encoding one of 3 common alleles (ε2, ε3, ε4) produced from combinations of 2 non-synonymous SNPs (rs429358 and rs7412). APOE plays an important role controlling plasma lipids but its association with adipocyte functionality and body fatness remains to be determined.
methodsWe analyzed fasting plasma lipids and genotyped the two main APOE-SNPs (rs429358 and rs7412), both located in the fourth exon of the APOE, in 4660 Caucasian middle-aged men free of cardiovascular disease.
resultsThe rs7412 SNP, which determines the APOE2 isoform, was significantly associated with Body Mass Index (BMI) and Waist Girth (WG) in a multivariate model accounting for age, smoking status and plasma lipids. BMI and WG were highest in TT homozygotes and lowest in CC homozygotes. This effect was independent of the rs429358 SNP, which failed to show any association with the BMI and WG variables. The odds ratio of being obese (BMI>30) for individuals carrying the APOε2 allele, present in 14% of the cohort and defined by the rs7412 SNP, was also significant in this multivariate model, with an OR of 1.27 (95% CI: 1.01-1.59).
conclusionsThis study provides an evidence of a lipid-independent association between the APOE SNP rs7412 and body fatness surrogates, BMI and WG, in a large cohort of middle-aged males.
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