Evidence map›Paper›PMID 25268586›Full record

ArticleThe Journal of investigative dermatology2015

Psoriatic inflammation facilitates the onset of arthritis in a mouse model.

Mayuko Yamamoto, Kimiko Nakajima, Mikiro Takaishi, Shun Kitaba, Yasuhiro Magata, Sayo Kataoka, Shigetoshi Sano

Abstract read
PubMed Publisher
In one paragraph

Article in The Journal of investigative dermatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 46 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Challenges and opportunities in animal models of psoriatic arthritis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023
    Review
  5. Mouse Models of Psoriasis: A Comprehensive Review.The Journal of investigative dermatology · 2022
    Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Psoriasis: Past, Present, and Future.The Journal of investigative dermatology · 2019
    Review
  13. Review
  14. Review
  15. Editorial: STATus of STAT3 in Psoriatic Arthritis.Arthritis & rheumatology (Hoboken, N.J.) · 2018
    Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Mayuko YamamotoDepartment of Dermatology, Kochi Medical School, Kochi University, Nankoku, Japan.
Kimiko NakajimaDepartment of Dermatology, Kochi Medical School, Kochi University, Nankoku, Japan.
Mikiro TakaishiDepartment of Dermatology, Kochi Medical School, Kochi University, Nankoku, Japan.
Shun KitabaDepartment of Dermatology, Graduate School of Medicine, Osaka University, Suita, Japan.
Yasuhiro MagataDepartment of Molecular Imaging, Applied Medical Photonics Laboratory, Medical Photonics Research Center, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Sayo KataokaScience Research Center, Kochi University, Nankoku, Japan.
Shigetoshi SanoDepartment of Dermatology, Kochi Medical School, Kochi University, Nankoku, Japan. Electronic address: sano.derma@kochi-u.ac.jp.
Kōchi University · JPHamamatsu University School of Medicine · JPKochi Medical School Hospital · JPThe University of Osaka · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Psoriatic arthritis (PsA) is a seronegative, inflammatory joint disease associated with psoriasis. In most patients with PsA, skin lesions precede arthritis; however, the causality of skin inflammation for the development of arthritis remains unclear. Gp130F759/F759 knock-in (F759) mice develop autoimmune arthritis after 1 year of age through persistent signal transducer and activator of transcription 3 (Stat3) activation due to impairment in SOCS3-dependent negative regulation. Here, we crossed F759 mice with K5.Stat3C transgenic mice, in which keratinocytes express constitutive active Stat3 (Stat3C), leading to generation of psoriasis-like skin change. F759 mice harboring the K5.Stat3C transgene not only had aggravated skin lesions but also spontaneously developed arthritis with high penetrance in adjacent paws as early as 3 weeks of age. The joint lesions included swelling of the peripheral paws and nail deformities contiguous with the skin lesions, closely resembling PsA. Histopathologic study revealed enthesitis and bone erosions, with mononuclear cell infiltrates. Quantitative reverse transcriptase-PCR (RT-PCR), immunohistochemical analyses, and flow cytometry showed upregulation of the IL-23/T helper type 17 (Th17) pathway in affected joints. Furthermore, enforced generation of psoriasis-like skin inflammation by topical treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) in F759 mice induced swelling of the underlying joints. This animal model renders psoriatic inflammation as the driver of arthritis and helps to further understand the pathogenesis of PsA.

Indexed as

AnimalsArthritis, PsoriaticCytokinesDisease Models, AnimalInflammationJoint DiseasesMiceMice, Inbred C57BLPsoriasisSkin DiseasesSTAT3 Transcription FactorTetradecanoylphorbol AcetateTh17 CellsCytokinesStat3 protein, mouseSTAT3 Transcription FactorTetradecanoylphorbol Acetate

Identifiers

PMID25268586
OpenAlexW2028496619

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.