ArticlePloS one2014
The CXCL12 G801A polymorphism is associated with cancer risk: a meta-analysis.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 3 of them syntheses that pooled it.
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Who cites it
9 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Association of the CXCL12 rs1801157 Polymorphism with Breast Cancer Risk: A Meta-Analysis.Asian Pacific journal of cancer prevention : APJCP · 2024Pooled it
- The SDF-1 rs1801157 Polymorphism is Associated with Cancer Risk: An Update Pooled Analysis and FPRP Test of 17,876 Participants.Scientific reports · 2016Pooled it
- Association of TCF4 polymorphisms and Fuchs' endothelial dystrophy: a meta-analysis.BMC ophthalmology · 2015Pooled it
- Associations of CXCL12 polymorphisms with clinicopathological features in breast cancer: a case-control study.Molecular biology reports · 2022Article
- Genetic Modifiers of the Breast Tumor Microenvironment.Trends in cancer · 2018Review
- The CXCL12 rs1801157 polymorphism and risk of colorectal cancer: a meta-analysis.OncoTargets and therapy · 2018Article
- Relationship between rs1801157 polymorphism in stromal cell-derived factor gene and systemic lupus erythematosus risk.Oncotarget · 2017Article
- Article
- Analysis of the expression of SDF-1 splicing variants in human colorectal cancer and normal mucosa tissues.Oncology letters · 2016Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCXCL12 is a small chemotactic cytokine belonging to the CXC chemokine family expressed in various organs. It contributes to the migration, invasion and angiogenesis of cancer cells. Recently, the CXCL12 G801A polymorphism was shown to be associated with an increased risk of various kinds of cancers, but the results were too inconsistent to be conclusive.
methodsTo solve the problem of inadequate statistical power and conflicting results, a meta-analysis of published case-control studies was performed, including 4,435 cancer cases and 6,898 controls. Odds ratios (ORs) and their 95% confidence intervals (CIs) were used to determine the strength of association between CXCL12 G801A polymorphism and cancer risk.
resultsA significant association between CXCL12 G801A polymorphism and cancer risk was found under all genetic models. Further, subgroup analysis stratified by ethnicity suggested a significant association between CXCL12 G801A polymorphism and cancer risk in the Asian subgroup under all genetic models. However, in the Caucasian subgroup, a significant association was only found under an additive genetic model and a dominant genetic model. The analysis stratified by cancer type found that CXCL12 G801A polymorphism may increase the risk of breast cancer, lung cancer, and "other" cancers. Based on subgroup stratified by source of controls, a significant association was observed in hospital-based studies under all genetic models.
conclusionsThe CXCL12 G801A polymorphism is associated with an increased risk of cancer based on current published data. In the future, large-scale well-designed studies with more information are needed to better estimate possible gene-gene or gene-environment interactions.
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