Evidence map›Paper›PMID 25267932›Full record

ArticleInterventional medicine & applied science2012

Menstrual blood transplantation for ischemic stroke: Therapeutic mechanisms and practical issues.

Maria Carolina O Rodrigues, Dmitriy Dmitriev, Antonio Rodrigues, Loren E Glover, Paul R Sanberg, Julie G Allickson, Nicole Kuzmin-Nichols, Naoki Tajiri, Kazutaka Shinozuka, Svitlana Garbuzova-Davis and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Interventional medicine & applied science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Maria Carolina O RodriguesDepartment of Neurosurgery and Brain Repair, University of South Florida, College of Medicine, Tampa, FL, USA ; Department of Internal Medicine, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Dmitriy DmitrievDepartment of Neurosurgery and Brain Repair, University of South Florida, College of Medicine, Tampa, FL, USA.
Antonio RodriguesDepartment of Neurosurgery and Brain Repair, University of South Florida, College of Medicine, Tampa, FL, USA ; Department of Internal Medicine, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Loren E GloverDepartment of Neurosurgery and Brain Repair, University of South Florida, College of Medicine, Tampa, FL, USA.
Paul R SanbergDepartment of Neurosurgery and Brain Repair, University of South Florida, College of Medicine, Tampa, FL, USA.
Julie G AllicksonCryo-Cell International, Inc., Tampa, FL, USA.
Nicole Kuzmin-NicholsSaneron-CCEL Therapeutics Inc., Tampa, FL, USA.
Naoki TajiriDepartment of Neurosurgery and Brain Repair, University of South Florida, College of Medicine, Tampa, FL, USA.
Kazutaka ShinozukaDepartment of Neurosurgery and Brain Repair, University of South Florida, College of Medicine, Tampa, FL, USA.
Svitlana Garbuzova-DavisDepartment of Neurosurgery and Brain Repair, University of South Florida, College of Medicine, Tampa, FL, USA.
Yuji KanekoDepartment of Neurosurgery and Brain Repair, University of South Florida, College of Medicine, Tampa, FL, USA.
Cesar V BorlonganDepartment of Neurosurgery and Brain Repair, University of South Florida, College of Medicine, Tampa, FL, USA.

Funding

Blood-Brain Barrier Repair in Cell Therapy for StrokeR01NS071956 · NINDS · UNIVERSITY OF SOUTH FLORIDA · PI BORLONGAN, CESARIO V, GARBUZOVA-DAVIS, SVITLANA NICOLAI · 2011 to 2015
$2.1M
NINDS NIH HHS R01 NS071956
6 · The paper itself

Abstract

Cerebrovascular diseases are a major cause of death and long-term disability in developed countries. Tissue plasmin activator (tPA) is the only approved therapy for ischemic stroke, strongly limited by the short therapeutic window and hemorrhagic complications, therefore excluding most patients from its benefits. The rescue of the penumbra area of the ischemic infarct is decisive for functional recovery after stroke. Inflammation is a key feature in the penumbra area and it plays a dual role, improving injury in early phases but impairing neural survival at later stages. Stem cells can be opportunely used to modulate inflammation, abrogate cell death and, therefore, preserve neural function. We here discuss the possible role of stem cells derived from menstrual blood as restorative treatment for stroke. We highlight the availability, proliferative capacity, pluripotentiality and angiogenic features of these cells and explore their present and future experimental and clinical applications.

Indexed as

cell-based therapyendometrium-derived stem cellsmenstrual blood stem cellspenumbra arearestorative treatmentstroke

Identifiers

PMID25267932
PMCPMC4177033

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.