Evidence map›Paper›PMID 25267931›Full record

ArticleArtery research2014

ENDOTHELIN-1 SYTEM ACTIVITY IN ADULTS WITH BORDERLINE HIGH LDL-CHOLESTEROL.

Kyle J Diehl, Brian L Stauffer, Jared J Greiner, Christopher A DeSouza

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Artery research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 85% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kyle J DiehlIntegrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado, Boulder, CO 80309.
Brian L StaufferIntegrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado, Boulder, CO 80309 ; Integrative Vascular Biology Laboratory, Department of Medicine, University of Colorado Denver and the Health Sciences Center, Aurora, CO 80045 ; Integrative Vascular Biology Laboratory, Denver Health Medical Center, Denver, CO 80204.
Jared J GreinerIntegrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado, Boulder, CO 80309.
Christopher A DeSouzaIntegrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado, Boulder, CO 80309 ; Integrative Vascular Biology Laboratory, Department of Medicine, University of Colorado Denver and the Health Sciences Center, Aurora, CO 80045.
University of Colorado Boulder · US

Funding

Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
Colorado Clinical and Translational Science Institute (UL1)UL1TR000154 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2012 to 2013
$20.4M
Obesity/Insulin Resistance, Vitamin C and Endothelin-1R01HL076434 · NHLBI · UNIVERSITY OF COLORADO AT BOULDER · PI DESOUZA, CHRISTOPHER A · 2004 to 2008
$1.5M
Aging, Exercise and Endothelin-1 Vasoconstrictor ToneR01HL077450 · NHLBI · UNIVERSITY OF COLORADO AT BOULDER · PI DESOUZA, CHRISTOPHER A · 2004 to 2007
$1.4M
NCATS NIH HHS UL1 TR000154NCATS NIH HHS UL1 TR001082NHLBI NIH HHS R01 HL076434NHLBI NIH HHS R01 HL077450
6 · The paper itself

Abstract

backgroundModest elevations in plasma low-density lipoprotein (LDL)-cholesterol have been shown to confer a significant increase in cardiovascular risk. Endothelin (ET)-1 is a vasoconstrictor peptide with proatherogenic properties. The experimental aim of this study was to determine whether ET-1 system activity is elevated in adults with borderline high LDL-cholesterol, independent of other cardiometabolic abnormalities.

methodsForearm blood flow (FBF; plethysmography) responses to intra-arterial infusion of ET-1, selective ET

resultsBoth groups demonstrated a similar, non-significant (~10%) reduction in FBF to ET-1. BQ-123 and BQ-123+788 elicited a modest, but significant, increase in FBF (~15-20%) in each group. However, there were no group differences in the FBF responses to either selective ET

conclusionBorderline-high LDL-C is not associated with increased ET-1 mediated vasoconstrictor tone. Disrupted ET-1 system activity may not contribute to the increased cardiovascular risk burden with borderline-high LDL-cholesterol.

Identifiers

PMID25267931
PMCPMC4175439
OpenAlexW2086885605

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.