Evidence map›Paper›PMID 25267916›Full record

ArticleThe Cochrane database of systematic reviews2011

Prophylactic vaccination against human papillomaviruses to prevent cervical cancer and its precursors.

Marc Arbyn, Andrew Bryant, Philippe Beutels, Pierre Pl Martin-Hirsch, Evangelos Paraskevaidis, Elke Van Hoof, Marc Steben, Youlin Qiao, Fang-Hui Zhao, Achim Schneider and 4 more

Abstract read
In one paragraph

Article in The Cochrane database of systematic reviews, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 43 citations in OpenAlex.

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  20. Human Papillomavirus (HPV) Vaccination Motivators, Barriers, and Brochure Preferences Among Parents in Multicultural Hawai'i: a Qualitative Study.Journal of cancer education : the official journal of the American Association for Cancer Education · 2017
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 11 institutions in 9 countries.

Marc ArbynUnit of Cancer Epidemiology, Scientific Institute of Public Health, Brussels, Belgium.
Andrew BryantInstitute of Health and Society, Newcastle University, Newcastle upon Tyne, UK.
Philippe BeutelsCentre for Health Economics Research and Modeling Infectious Diseases (CHERMID), Vaccine & Infectious Disease Institute (VAXINFECTIO), Antwerp, Belgium.
Pierre Pl Martin-HirschGynaecological Oncology Unit, Royal Preston Hospital, Lancashire Teaching Hospital NHS Trust, Preston, UK.
Evangelos ParaskevaidisDepartment of Obstetrics and Gynaecology, Ioannina University Hospital, Ioannina, Greece.
Elke Van HoofBelgian Cancer Centre, Scientific Institute of Public Health, Brussels, Belgium.
Marc StebenDirection Des Risques Biologiques et de la Santé au Travail, Montréal (Québec), Canada.
Youlin QiaoDepartment of Cancer Epidemiology, Cancer Institute, Beijing, China.
Fang-Hui ZhaoDepartment of Cancer Epidemiology, Cancer Institute, Beijing, China.
Achim SchneiderDepartment of Gynecology and Gynecologic Oncology, Berlin, Germany.
Andreas KaufmannGynäkologische Tumorimmunologie, Charite Campus Benjamin Franklin, Berlin, Germany.
Joakim DillnerDepartment of Clinical Microbiology, WHO HPV LabNet Global Reference Laboratory, Stockholm, Sweden.
Lauri MarkowitzESB/DSTDP/NCHHSTP, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Allan HildesheimDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Institut Scientifique de Santé Publique · BEPeking University Cancer Hospital · CNCenters for Disease Control and Prevention · USFranklin University · USGynecologic Oncology Group · USInfectious Diseases Institute · UGNational Cancer Institute · USNewcastle University · GBRLS Global (Sweden) · SERoyal Preston Hospital · GBUniversity Hospital of Ioannina · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows: To evaluate the immunogenicity, clinical efficacy, and safety of prophylactic HPV vaccines in females. The assessment of clinical efficacy will address protection against HPV infection (for homologous and heterologous HPV types), against re-infection, against cervical cancer and its precursors (high-grade CIN (grade 2 or grade 3), adenocarcinoma in situ) in women previously not exposed to HPV infection (negative at enrolment for both HPV DNA and antibodies against the vaccine HPV types). We will assess clinical effectiveness by evaluating outcomes in all women, irrespective of the HPV DNA or serology status at enrolment. Evaluation by fine age and time since sexual debut categories is also planned.

Identifiers

PMID25267916
PMCPMC4176676
OpenAlexW4246886805

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.