Evidence map›Paper›PMID 25267793›Full record

ArticleDatabase : the journal of biological databases and curation2014

An online system for metabolic network analysis.

Abdullah Ercument Cicek, Xinjian Qi, Ali Cakmak, Stephen R Johnson, Xu Han, Sami Alshalwi, Zehra Meral Ozsoyoglu, Gultekin Ozsoyoglu

Abstract read
In one paragraph

Article in Database : the journal of biological databases and curation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Abdullah Ercument CicekLane Center for Computational Biology, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA 15222, USA, Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, OH 44106, USA and Department of Computer Science, Istanbul Sehir University, Istanbul 34662, Turkey cicek@cs.cmu.edu.
Xinjian QiLane Center for Computational Biology, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA 15222, USA, Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, OH 44106, USA and Department of Computer Science, Istanbul Sehir University, Istanbul 34662, Turkey.
Ali CakmakLane Center for Computational Biology, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA 15222, USA, Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, OH 44106, USA and Department of Computer Science, Istanbul Sehir University, Istanbul 34662, Turkey.
Stephen R JohnsonLane Center for Computational Biology, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA 15222, USA, Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, OH 44106, USA and Department of Computer Science, Istanbul Sehir University, Istanbul 34662, Turkey.
Xu HanLane Center for Computational Biology, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA 15222, USA, Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, OH 44106, USA and Department of Computer Science, Istanbul Sehir University, Istanbul 34662, Turkey.
Sami AlshalwiLane Center for Computational Biology, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA 15222, USA, Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, OH 44106, USA and Department of Computer Science, Istanbul Sehir University, Istanbul 34662, Turkey.
Zehra Meral OzsoyogluLane Center for Computational Biology, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA 15222, USA, Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, OH 44106, USA and Department of Computer Science, Istanbul Sehir University, Istanbul 34662, Turkey.
Gultekin OzsoyogluLane Center for Computational Biology, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA 15222, USA, Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, OH 44106, USA and Department of Computer Science, Istanbul Sehir University, Istanbul 34662, Turkey.

Funding

Systems Biology Approach to Growth Regulation in Cystic FibrosisR01GM088823 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI DRUMM, MITCHELL L · 2009 to 2012
$1.6M
NIGMS NIH HHS GM088823
6 · The paper itself

Abstract

Metabolic networks have become one of the centers of attention in life sciences research with the advancements in the metabolomics field. A vast array of studies analyzes metabolites and their interrelations to seek explanations for various biological questions, and numerous genome-scale metabolic networks have been assembled to serve for this purpose. The increasing focus on this topic comes with the need for software systems that store, query, browse, analyze and visualize metabolic networks. PathCase Metabolomics Analysis Workbench (PathCaseMAW) is built, released and runs on a manually created generic mammalian metabolic network. The PathCaseMAW system provides a database-enabled framework and Web-based computational tools for browsing, querying, analyzing and visualizing stored metabolic networks. PathCaseMAW editor, with its user-friendly interface, can be used to create a new metabolic network and/or update an existing metabolic network. The network can also be created from an existing genome-scale reconstructed network using the PathCaseMAW SBML parser. The metabolic network can be accessed through a Web interface or an iPad application. For metabolomics analysis, steady-state metabolic network dynamics analysis (SMDA) algorithm is implemented and integrated with the system. SMDA tool is accessible through both the Web-based interface and the iPad application for metabolomics analysis based on a metabolic profile. PathCaseMAW is a comprehensive system with various data input and data access subsystems. It is easy to work with by design, and is a promising tool for metabolomics research and for educational purposes. Database URL: http://nashua.case.edu/PathwaysMAW/Web.

Indexed as

Databases, GeneticInternetMetabolic Networks and PathwaysUser-Computer InterfaceMetabolomicsSoftware

Identifiers

PMID25267793
PMCPMC4178370

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.