Evidence map›Paper›PMID 25267791›Full record

ArticleThe Journal of experimental medicine2014

Immunoglobulin E plays an immunoregulatory role in lupus.

Barbara Dema, Nicolas Charles, Christophe Pellefigues, Tiffany K Ricks, Ryo Suzuki, Chao Jiang, Jorg Scheffel, Sarfaraz Hasni, Victoria Hoffman, Mathieu Jablonski and 7 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of experimental medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 86 citations in OpenAlex.

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  16. AMG853, A Bispecific Prostaglandin DFrontiers in immunology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 11 institutions in 2 countries.

Barbara DemaMolecular Immunology Section, Laboratory of Molecular Immunogenetics, Office of the Clinical Director, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892 Centre de Recherche sur l'Inflammation, INSERM UMR1149, CNRS ERL8252 Universite Paris Diderot, Laboratoire d'Excellence Inflamex, DHU FIRE, 75018 Paris, France.
Nicolas CharlesCentre de Recherche sur l'Inflammation, INSERM UMR1149, CNRS ERL8252 Universite Paris Diderot, Laboratoire d'Excellence Inflamex, DHU FIRE, 75018 Paris, France.
Christophe PellefiguesCentre de Recherche sur l'Inflammation, INSERM UMR1149, CNRS ERL8252 Universite Paris Diderot, Laboratoire d'Excellence Inflamex, DHU FIRE, 75018 Paris, France.
Tiffany K RicksMolecular Immunology Section, Laboratory of Molecular Immunogenetics, Office of the Clinical Director, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892.
Ryo SuzukiMolecular Immunology Section, Laboratory of Molecular Immunogenetics, Office of the Clinical Director, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892.
Chao JiangMolecular Immunology Section, Laboratory of Molecular Immunogenetics, Office of the Clinical Director, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892.
Jorg ScheffelMolecular Immunology Section, Laboratory of Molecular Immunogenetics, Office of the Clinical Director, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892.
Sarfaraz HasniMolecular Immunology Section, Laboratory of Molecular Immunogenetics, Office of the Clinical Director, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892.
Victoria HoffmanDiagnostic and Research Services Branch, Office of the Director, Autoimmunity and Functional Genomics Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
Mathieu JablonskiDepartment of Nephrology, Department of Internal Medicine, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, Université Paris Diderot, Faculte de Medecine site Bichat, 75018 Paris, France.
Karim SacréCentre de Recherche sur l'Inflammation, INSERM UMR1149, CNRS ERL8252 Universite Paris Diderot, Laboratoire d'Excellence Inflamex, DHU FIRE, 75018 Paris, France Department of Nephrology, Department of Internal Medicine, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, Université Paris Diderot, Faculte de Medecine site Bichat, 75018 Paris, France.
Delphine GobertDepartment of Nephrology, Department of Internal Medicine, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, Université Paris Diderot, Faculte de Medecine site Bichat, 75018 Paris, France.
Thomas PapoCentre de Recherche sur l'Inflammation, INSERM UMR1149, CNRS ERL8252 Universite Paris Diderot, Laboratoire d'Excellence Inflamex, DHU FIRE, 75018 Paris, France Department of Nephrology, Department of Internal Medicine, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, Université Paris Diderot, Faculte de Medecine site Bichat, 75018 Paris, France.
Eric DaugasCentre de Recherche sur l'Inflammation, INSERM UMR1149, CNRS ERL8252 Universite Paris Diderot, Laboratoire d'Excellence Inflamex, DHU FIRE, 75018 Paris, France Department of Nephrology, Department of Internal Medicine, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, Université Paris Diderot, Faculte de Medecine site Bichat, 75018 Paris, France.
Steve CramptonDiagnostic and Research Services Branch, Office of the Director, Autoimmunity and Functional Genomics Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
Silvia BollandDiagnostic and Research Services Branch, Office of the Director, Autoimmunity and Functional Genomics Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
Juan RiveraMolecular Immunology Section, Laboratory of Molecular Immunogenetics, Office of the Clinical Director, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892 juan_rivera@nih.gov.
National Institutes of Health · USCentre National de la Recherche Scientifique · FRNational Institute of Arthritis and Musculoskeletal and Skin Diseases · USAssistance Publique – Hôpitaux de Paris · FRCentre de Recherche sur l'Inflammation · FRDélégation Paris 7 · FRHôpital Bichat-Claude-Bernard · FRNational Institute of Allergy and Infectious Diseases · USOffice of the Director · USPediatric Nephrology of Alabama · USUniversité Paris Cité · FR

Funding

Clinical Support Services for the NIAMS Intramural Research ProgramZIDAR041180 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI COLBERT, ROBERT · 2009 to 2025
$119.2M
Genetic Modifiers Of Autoimmune Disease In FcgammaRIIB Mutant MiceZIAAI000912 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI BOLLAND, SILVIA · 2009 to 2025
$27.0M
Intramural NIH HHS
6 · The paper itself

Abstract

The (patho)physiological role of IgE in nonallergic inflammatory diseases is not well understood. Here, we explored the effect of IgE deficiency on the inflammatory response in FcγRIIB-deficient mice as well as in mice carrying both a deletion of FcγRIIB and the chromosomal translocation of Y-linked autoimmune acceleration (Yaa) that hastens and results in a more aggressive lupuslike disease in these mice. The findings show that deficiency of IgE delays disease development and severity as demonstrated by reduced autoantibody production and amelioration of organ pathologies. This was associated with decreased numbers of plasma cells and reduced levels of IgG2b and IgG3. Unexpectedly, the loss of IgE also caused a striking decrease of immune cell infiltration in secondary lymphoid organs with a marked effect on the presence of dendritic cells, monocytes, neutrophils, and eosinophils in these organs and decreased activation of basophils. The presence of autoreactive IgE in human systemic lupus erythematosus subjects was also associated with increased basophil activation and enhanced disease activity. These findings argue that IgE facilitates the amplification of autoimmune inflammation.

Indexed as

ImmunomodulationAnimalsAutoantibodiesAutoimmunityBasophilsB-LymphocytesB-Lymphocyte SubsetsCase-Control StudiesCD4-CD8 RatioDisease Models, AnimalHumansImmunoglobulin EInflammationKidney GlomerulusLupus Erythematosus, SystemicLymphocyte CountAutoantibodiesImmunoglobulin EReceptors, IgG

Identifiers

PMID25267791
PMCPMC4203948
OpenAlexW2034314827

What OpenQuestion holds

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LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.