Evidence map›Paper›PMID 25267739›Full record

ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2014

Body mass index and risk of second obesity-associated cancers after colorectal cancer: a pooled analysis of prospective cohort studies.

Todd M Gibson, Yikyung Park, Kim Robien, Meredith S Shiels, Amanda Black, Joshua N Sampson, Mark P Purdue, Laura E Beane Freeman, Gabriella Andreotti, Stephanie J Weinstein and 5 more

Open access · bronzeAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 85 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Association of patient factors and health-related quality of life with weight changes during chemotherapy for colorectal cancer: secondary analysis of the SCOT trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Trial
  4. Article
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  11. Review
  12. Is sleep associated with BMI, waist circumference, and diet among long-term colorectal cancer survivors? Results from the population-based PROFILES registry.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. NCCN Guidelines Insights: Survivorship, Version 2.2020.Journal of the National Comprehensive Cancer Network : JNCCN · 2020
    Article
  18. Article
  19. Article
  20. Survivorship Guidance for Patients with Colorectal Cancer.Current treatment options in oncology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Todd M GibsonTodd M. Gibson, Yikyung Park, Meredith S. Shiels, Amanda Black, Joshua N. Sampson, Mark P. Purdue, Laura E. Beane Freeman, Gabriella Andreotti, Stephanie J. Weinstein, Demetrius Albanes, Joseph F. Fraumeni Jr, Rochelle E. Curtis, Amy Berrington de Gonzalez, Lindsay M. Morton, National Cancer Institute, Bethesda, MD; and Kim Robien, Milken Institute School of Public Health, George Washington University, Washington, DC. todd.gibson@stjude.org.
Yikyung ParkTodd M. Gibson, Yikyung Park, Meredith S. Shiels, Amanda Black, Joshua N. Sampson, Mark P. Purdue, Laura E. Beane Freeman, Gabriella Andreotti, Stephanie J. Weinstein, Demetrius Albanes, Joseph F. Fraumeni Jr, Rochelle E. Curtis, Amy Berrington de Gonzalez, Lindsay M. Morton, National Cancer Institute, Bethesda, MD; and Kim Robien, Milken Institute School of Public Health, George Washington University, Washington, DC.
Kim RobienTodd M. Gibson, Yikyung Park, Meredith S. Shiels, Amanda Black, Joshua N. Sampson, Mark P. Purdue, Laura E. Beane Freeman, Gabriella Andreotti, Stephanie J. Weinstein, Demetrius Albanes, Joseph F. Fraumeni Jr, Rochelle E. Curtis, Amy Berrington de Gonzalez, Lindsay M. Morton, National Cancer Institute, Bethesda, MD; and Kim Robien, Milken Institute School of Public Health, George Washington University, Washington, DC.
Meredith S ShielsTodd M. Gibson, Yikyung Park, Meredith S. Shiels, Amanda Black, Joshua N. Sampson, Mark P. Purdue, Laura E. Beane Freeman, Gabriella Andreotti, Stephanie J. Weinstein, Demetrius Albanes, Joseph F. Fraumeni Jr, Rochelle E. Curtis, Amy Berrington de Gonzalez, Lindsay M. Morton, National Cancer Institute, Bethesda, MD; and Kim Robien, Milken Institute School of Public Health, George Washington University, Washington, DC.
Amanda BlackTodd M. Gibson, Yikyung Park, Meredith S. Shiels, Amanda Black, Joshua N. Sampson, Mark P. Purdue, Laura E. Beane Freeman, Gabriella Andreotti, Stephanie J. Weinstein, Demetrius Albanes, Joseph F. Fraumeni Jr, Rochelle E. Curtis, Amy Berrington de Gonzalez, Lindsay M. Morton, National Cancer Institute, Bethesda, MD; and Kim Robien, Milken Institute School of Public Health, George Washington University, Washington, DC.
Joshua N SampsonTodd M. Gibson, Yikyung Park, Meredith S. Shiels, Amanda Black, Joshua N. Sampson, Mark P. Purdue, Laura E. Beane Freeman, Gabriella Andreotti, Stephanie J. Weinstein, Demetrius Albanes, Joseph F. Fraumeni Jr, Rochelle E. Curtis, Amy Berrington de Gonzalez, Lindsay M. Morton, National Cancer Institute, Bethesda, MD; and Kim Robien, Milken Institute School of Public Health, George Washington University, Washington, DC.
Mark P PurdueTodd M. Gibson, Yikyung Park, Meredith S. Shiels, Amanda Black, Joshua N. Sampson, Mark P. Purdue, Laura E. Beane Freeman, Gabriella Andreotti, Stephanie J. Weinstein, Demetrius Albanes, Joseph F. Fraumeni Jr, Rochelle E. Curtis, Amy Berrington de Gonzalez, Lindsay M. Morton, National Cancer Institute, Bethesda, MD; and Kim Robien, Milken Institute School of Public Health, George Washington University, Washington, DC.
Laura E Beane FreemanTodd M. Gibson, Yikyung Park, Meredith S. Shiels, Amanda Black, Joshua N. Sampson, Mark P. Purdue, Laura E. Beane Freeman, Gabriella Andreotti, Stephanie J. Weinstein, Demetrius Albanes, Joseph F. Fraumeni Jr, Rochelle E. Curtis, Amy Berrington de Gonzalez, Lindsay M. Morton, National Cancer Institute, Bethesda, MD; and Kim Robien, Milken Institute School of Public Health, George Washington University, Washington, DC.
Gabriella AndreottiTodd M. Gibson, Yikyung Park, Meredith S. Shiels, Amanda Black, Joshua N. Sampson, Mark P. Purdue, Laura E. Beane Freeman, Gabriella Andreotti, Stephanie J. Weinstein, Demetrius Albanes, Joseph F. Fraumeni Jr, Rochelle E. Curtis, Amy Berrington de Gonzalez, Lindsay M. Morton, National Cancer Institute, Bethesda, MD; and Kim Robien, Milken Institute School of Public Health, George Washington University, Washington, DC.
Stephanie J WeinsteinTodd M. Gibson, Yikyung Park, Meredith S. Shiels, Amanda Black, Joshua N. Sampson, Mark P. Purdue, Laura E. Beane Freeman, Gabriella Andreotti, Stephanie J. Weinstein, Demetrius Albanes, Joseph F. Fraumeni Jr, Rochelle E. Curtis, Amy Berrington de Gonzalez, Lindsay M. Morton, National Cancer Institute, Bethesda, MD; and Kim Robien, Milken Institute School of Public Health, George Washington University, Washington, DC.
Demetrius AlbanesTodd M. Gibson, Yikyung Park, Meredith S. Shiels, Amanda Black, Joshua N. Sampson, Mark P. Purdue, Laura E. Beane Freeman, Gabriella Andreotti, Stephanie J. Weinstein, Demetrius Albanes, Joseph F. Fraumeni Jr, Rochelle E. Curtis, Amy Berrington de Gonzalez, Lindsay M. Morton, National Cancer Institute, Bethesda, MD; and Kim Robien, Milken Institute School of Public Health, George Washington University, Washington, DC.
Joseph F FraumeniTodd M. Gibson, Yikyung Park, Meredith S. Shiels, Amanda Black, Joshua N. Sampson, Mark P. Purdue, Laura E. Beane Freeman, Gabriella Andreotti, Stephanie J. Weinstein, Demetrius Albanes, Joseph F. Fraumeni Jr, Rochelle E. Curtis, Amy Berrington de Gonzalez, Lindsay M. Morton, National Cancer Institute, Bethesda, MD; and Kim Robien, Milken Institute School of Public Health, George Washington University, Washington, DC.
Rochelle E CurtisTodd M. Gibson, Yikyung Park, Meredith S. Shiels, Amanda Black, Joshua N. Sampson, Mark P. Purdue, Laura E. Beane Freeman, Gabriella Andreotti, Stephanie J. Weinstein, Demetrius Albanes, Joseph F. Fraumeni Jr, Rochelle E. Curtis, Amy Berrington de Gonzalez, Lindsay M. Morton, National Cancer Institute, Bethesda, MD; and Kim Robien, Milken Institute School of Public Health, George Washington University, Washington, DC.
Amy Berrington de GonzalezTodd M. Gibson, Yikyung Park, Meredith S. Shiels, Amanda Black, Joshua N. Sampson, Mark P. Purdue, Laura E. Beane Freeman, Gabriella Andreotti, Stephanie J. Weinstein, Demetrius Albanes, Joseph F. Fraumeni Jr, Rochelle E. Curtis, Amy Berrington de Gonzalez, Lindsay M. Morton, National Cancer Institute, Bethesda, MD; and Kim Robien, Milken Institute School of Public Health, George Washington University, Washington, DC.
Lindsay M MortonTodd M. Gibson, Yikyung Park, Meredith S. Shiels, Amanda Black, Joshua N. Sampson, Mark P. Purdue, Laura E. Beane Freeman, Gabriella Andreotti, Stephanie J. Weinstein, Demetrius Albanes, Joseph F. Fraumeni Jr, Rochelle E. Curtis, Amy Berrington de Gonzalez, Lindsay M. Morton, National Cancer Institute, Bethesda, MD; and Kim Robien, Milken Institute School of Public Health, George Washington University, Washington, DC.

Funding

Studies of Populations Exposed to Therapeutic Medical Radiation and Other AgentsZIACP010131 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI MORTON, LINDSAY · 2009 to 2025
$81.0M
EPIDEMIOLOGY OF CANCER IN A COHORT OF OLDER WOMENR01CA039742 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI LAZOVICH, DEANN · 1985 to 2014
$8.0M
STUDIES OF OCCUPATIONAL CANCER--PESTICIDESZ01CP010119 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI ALAVANJA, MICHAEL · 1996 to 2008
$5.0M
HEALTH EFFECTS OF EXPOSURES IN AGRICULTUREZ01ES049030 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI SANDLER, DALE P · 1997 to 2008
$889k
Intramural NIH HHS Z01 CP010119Intramural NIH HHS Z01 ES049030NCI NIH HHS R01 CA039742NCI NIH HHS R01 CA39742NCI NIH HHS Z01-CP010119
6 · The paper itself

Abstract

purposeTo determine whether prediagnostic body mass index (BMI) is associated with risk of second obesity-associated cancers in colorectal cancer (CRC) survivors, and whether CRC survivors have increased susceptibility to obesity-associated cancer compared with cancer-free individuals. PATIENTS AND

methodsIncident first primary CRC cases (N = 11,598) were identified from five prospective cohort studies. We used Cox proportional hazards regression models to examine associations between baseline (prediagnostic) BMI and risk of second obesity-associated cancers (postmenopausal breast, kidney, pancreas, esophageal adenocarcinoma, endometrium) in CRC survivors, and compared associations to those for first obesity-associated cancers in the full cohort.

resultsCompared with survivors with normal prediagnostic BMI (18.5-24.9 kg/m(2)), those who were overweight (25-29.9 kg/m(2)) or obese (30+ kg/m(2)) had greater risk of a second obesity-associated cancer (n = 224; overweight hazard ratio [HR], 1.39; 95% CI, 1.01 to 1.92; obese HR, 1.47; 95% CI, 1.02 to 2.12; per 5-unit change in BMI HR, 1.12; 95% CI, 0.98 to 1.29). The magnitude of risk for developing a first primary obesity-associated cancer was similar (overweight HR, 1.18; 95% CI, 1.14 to 1.21; obese HR, 1.61; 95% CI, 1.56 to 1.66; per 5-unit change in BMI HR, 1.23; 95% CI, 1.21 to 1.24). Before diagnosis CRC patients were somewhat more likely than the overall cohort to be overweight (44% v 41%) or obese (25% v 21%).

conclusionCRC survivors who were overweight or obese before diagnosis had increased risk of second obesity-associated cancers compared with survivors with normal weight. The risks were similar in magnitude to those observed for first cancers in this population, suggesting increased prevalence of overweight or obesity, rather than increased susceptibility, may contribute to elevated second cancer risks in colorectal cancer survivors compared with the general population. These results support emphasis of existing weight guidelines for this high-risk group.

Indexed as

Body Mass IndexAgedBody CompositionBody WeightColorectal NeoplasmsFemaleHumansMaleMiddle AgedNeoplasms, Second PrimaryObesityOverweightProportional Hazards ModelsProspective StudiesRisk FactorsTreatment Outcome

Identifiers

PMID25267739
PMCPMC4251963
OpenAlexW2054258566

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.