ArticleMolecular plant2014
SPINDLY, ERECTA, and its ligand STOMAGEN have a role in redox-mediated cortex proliferation in the Arabidopsis root.
Article in Molecular plant, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 64 citations in OpenAlex.
- Systems-level proteomic models of cotton fiber development: a high-resolution data resource to analyze cell dynamics and trait engineering.Plant physiology · 2026Article
- ERECTA-family receptor kinases: versatile regulators of plant developmental signaling.The Plant journal : for cell and molecular biology · 2026Review
- ROS-mediated interplay between brassinosteroids and gibberellic acids antagonistically modulates asymmetric periclinal cell division leading to middle cortex formation inPlant signaling & behavior · 2025Article
- The peptide EPFL8 represses embryonic stomatal precursor formation independently of TOO MANY MOUTHS in Arabidopsis.Plant physiology · 2025Article
- A tale of two sugars: O-GlcNAc and O-fucose orchestrate growth, development, and acclimation in plants.Trends in biochemical sciences · 2025Review
- Integrative regulation of middle cortex formation: from classic modules to emerging pathways.Frontiers in plant science · 2025Review
- Rooting for survival: how plants tackle a challenging environment through a diversity of root forms and functions.Plant physiology · 2024Review
- Dynamic interplay of reactive oxygen and nitrogen species (ROS and RNS) in plant resilience: unveiling the signaling pathways and metabolic responses to biotic and abiotic stresses.Plant cell reports · 2024Review
- SCARECROW maintains the stem cell niche in Arabidopsis roots by ensuring telomere integrity.Plant physiology · 2023Article
- Transcriptome, Ectopic Expression and Genetic Population Analysis Identify Candidate Genes for Fiber Quality Improvement in Cotton.International journal of molecular sciences · 2023Article
- SPINDLY mediates O-fucosylation of hundreds of proteins and sugar-dependent growth in Arabidopsis.The Plant cell · 2023Article
- An LTR retrotransposon insertion inside CsERECTA for an LRR receptor-like serine/threonine-protein kinase results in compact (cp) plant architecture in cucumber.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Transcriptional control of hydrogen peroxide homeostasis regulates ground tissue patterning in theFrontiers in plant science · 2023Article
- Structural insights into mechanism and specificity of the plant protein O-fucosyltransferase SPINDLY.Nature communications · 2022Article
- Salicylic Acid in Root Growth and Development.International journal of molecular sciences · 2022Review
- It's Time for a Change: The Role of Gibberellin in Root Meristem Development.Frontiers in plant science · 2022Review
- Novel nucleocytoplasmic protein O-fucosylation by SPINDLY regulates diverse developmental processes in plants.Current opinion in structural biology · 2021Review
- Review
- Identification and Validation of a Prognostic Risk-Scoring Model Based on Ferroptosis-Associated Cluster in Acute Myeloid Leukemia.Frontiers in cell and developmental biology · 2021Article
- Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Reactive oxygen species (ROS) are harmful to all living organisms and therefore they must be removed to ensure normal growth and development. ROS are also signaling molecules, but so far little is known about the mechanisms of ROS perception and developmental response in plants. We here report that hydrogen peroxide induces cortex proliferation in the Arabidopsis root and that SPINDLY (SPY), an O-linked glucosamine acetyltransferase, regulates cortex proliferation by maintaining cellular redox homeostasis. We also found that mutation in the leucine-rich receptor kinase ERECTA and its putative peptide ligand STOMAGEN block the effect of hydrogen peroxide on root cortex proliferation. However, ERECTA and STOMAGEN are expressed in the vascular tissue, whereas extra cortex cells are produced from the endodermis, suggesting the involvement of intercellular signaling. SPY appears to act downstream of ERECTA, because the spy mutation still caused cortex proliferation in the erecta mutant background. We therefore have not only gained insight into the mechanism by which SPY regulates root development but also uncovered a novel pathway for ROS signaling in plants. The importance of redox-mediated cortex proliferation as a protective mechanism against oxidative stress is also discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.