ReviewDiabetologia1989
The insulin secretory granule.
Review in Diabetologia, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
74 citing papers in PubMed, 190 citations in OpenAlex.
- Mammals that can develop type 2 diabetes have a similarly structured β-sheet amyloid oligomer.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- A structural model of toxic amyloid oligomers involved in type 2 diabetes.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Understanding the structural dynamics of human islet amyloid polypeptide: Advancements in and applications of ion-mobility mass spectrometry.Biophysical chemistry · 2024Review
- Zinc and pH modulate the ability of insulin to inhibit aggregation of islet amyloid polypeptide.Communications biology · 2024Article
- Liquid-liquid phase separation facilitates the biogenesis of secretory storage granules.The Journal of cell biology · 2022Article
- Role of the voltage-gated proton channel Hv1 in insulin secretion, glucose homeostasis, and obesity.Journal of physiology and biochemistry · 2022Review
- Linking hIAPP misfolding and aggregation with type 2 diabetes mellitus: a structural perspective.Bioscience reports · 2022Review
- Integrative structural modelling and visualisation of a cellular organelle.QRB discovery · 2022Article
- Proteostasis of Islet Amyloid Polypeptide: A Molecular Perspective of Risk Factors and Protective Strategies for Type II Diabetes.Chemical reviews · 2021Review
- Surface-Catalyzed Secondary Nucleation Dominates the Generation of Toxic IAPP Aggregates.Frontiers in molecular biosciences · 2021Article
- Islet Function in the Pathogenesis of Cystic Fibrosis-Related Diabetes Mellitus.Clinical medicine insights. Endocrinology and diabetes · 2021Review
- There Is Something About Insulin Granules.Diabetes · 2020Article
- Liquid-liquid phase separation of type II diabetes-associated IAPP initiates hydrogelation and aggregation.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Culture on a native bone marrow-derived extracellular matrix restores the pancreatic islet basement membrane, preserves islet function, and attenuates islet immunogenicity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Site-Specific Interactions with Copper Promote Amyloid Fibril Formation for λ6aJL2-R24G.ACS omega · 2020Article
- Article
- IAPP/amylin and β-cell failure: implication of the risk factors of type 2 diabetes.Diabetology international · 2018Article
- hIAPP forms toxic oligomers in plasma.Chemical communications (Cambridge, England) · 2018Article
- Role of Zinc Homeostasis in the Pathogenesis of Diabetes and Obesity.International journal of molecular sciences · 2018Review
- Excess cholesterol inhibits glucose-stimulated fusion pore dynamics in insulin exocytosis.Journal of cellular and molecular medicine · 2017Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The insulin secretory granule of the pancreatic B cell is a complex intracellular organelle comprised of a many proteins with different catalytic activities and messenger functions. With the advent of tumour models of the B cells and the application of immunological and molecular cloning techniques considerable progress has been made in recent years towards the elucidation of the structure and function of these granule proteins. A number of examples are selected here for review. Particular emphasis given to how the activities of quite different granule proteins are interdependent and how this contributes to the co-ordination and integration of the organelle's biological functions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.