ArticleAntimicrobial agents and chemotherapy2014
New insights into chloramphenicol biosynthesis in Streptomyces venezuelae ATCC 10712.
Article in Antimicrobial agents and chemotherapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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40 citing papers in PubMed, 96 citations in OpenAlex.
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- Determining biosynthetic gene cluster boundaries through comparative bioinformatics.Methods in enzymology · 2025Article
- Genome sequence and characterization of Streptomyces phage Pablito, representing a new species within the genus Janusvirus.Scientific reports · 2022Article
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- Tas2R signaling enhances mouse neutrophil migrationFrontiers in immunology · 2022Article
- Streptomyces venezuelae NRRL B-65442: genome sequence of a model strain used to study morphological differentiation in filamentous actinobacteria.Journal of industrial microbiology & biotechnology · 2021Article
- AdpA Positively Regulates Morphological Differentiation and Chloramphenicol Biosynthesis in Streptomyces venezuelae.Microbiology spectrum · 2021Article
- Integrating perspectives in actinomycete research: an ActinoBase review of 2020-21.Microbiology (Reading, England) · 2021Review
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- A Major Facilitator Superfamily (MFS) Efflux Pump, SCO4121, from Streptomyces coelicolor with Roles in Multidrug Resistance and Oxidative Stress Tolerance and Its Regulation by a MarR Regulator.Applied and environmental microbiology · 2021Article
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- Discovery and biosynthesis of guanipiperazine from a NRPS-like pathway.Chemical science · 2021Article
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- Nonribosomal Peptides Produced by Minimal and Engineered Synthetases with Terminal Reductase Domains.Chembiochem : a European journal of chemical biology · 2020Article
- Comparative Genomics Determines Strain-Dependent Secondary Metabolite Production inBiomolecules · 2020Article
- The Diiron Monooxygenase CmlA from Chloramphenicol Biosynthesis Allows Reconstitution of β-Hydroxylation during Glycopeptide Antibiotic Biosynthesis.ACS chemical biology · 2019Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Comparative genome analysis revealed seven uncharacterized genes, sven0909 to sven0915, adjacent to the previously identified chloramphenicol biosynthetic gene cluster (sven0916-sven0928) of Streptomyces venezuelae strain ATCC 10712 that was absent in a closely related Streptomyces strain that does not produce chloramphenicol. Transcriptional analysis suggested that three of these genes might be involved in chloramphenicol production, a prediction confirmed by the construction of deletion mutants. These three genes encode a cluster-associated transcriptional activator (Sven0913), a phosphopantetheinyl transferase (Sven0914), and a Na(+)/H(+) antiporter (Sven0915). Bioinformatic analysis also revealed the presence of a previously undetected gene, sven0925, embedded within the chloramphenicol biosynthetic gene cluster that appears to encode an acyl carrier protein, bringing the number of new genes likely to be involved in chloramphenicol production to four. Microarray experiments and synteny comparisons also suggest that sven0929 is part of the biosynthetic gene cluster. This has allowed us to propose an updated and revised version of the chloramphenicol biosynthetic pathway.
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