ArticleProceedings of the National Academy of Sciences of the United States of America2014
Memory trace and timing mechanism localized to cerebellar Purkinje cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
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Who cites it
75 citing papers in PubMed.
- Independence and coherence in temporal sequence computation across the fronto-parietal network.Nature communications · 2026Article
- Cerebellar Time and Relative Time: A Comparator-Based Dynamical Timing Model and its Relevance to Psychopathology and Therapies.Cerebellum (London, England) · 2026Review
- Reductionism in Engram Neuroscience.The European journal of neuroscience · 2026Review
- Classical conditioning of Purkinje cell responsesBiochemistry and biophysics reports · 2026Article
- The anticipation of imminent events is time-scale invariant.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- A theory of cerebellar learning as spike-based reinforcement learning in continuous time and space.PNAS nexus · 2025Article
- Comparing the Representation of a Simple Visual Stimulus across the Cerebellar Network.eNeuro · 2024Article
- Mesoscale simulations predict the role of synergistic cerebellar plasticity during classical eyeblink conditioning.PLoS computational biology · 2024Article
- Emergence of syntax and word prediction in an artificial neural circuit of the cerebellum.Nature communications · 2024Article
- Expression of a Form of Cerebellar Motor Memory Requires Learned Alterations to the Activity of Inhibitory Molecular Layer Interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Cerebellar contributions across behavioural timescales: a review from the perspective of cerebro-cerebellar interactions.Frontiers in systems neuroscience · 2023Review
- A computational passage-of-time model of the cerebellar Purkinje cell in eyeblink conditioning.Frontiers in computational neuroscience · 2023Article
- Discrimination and learning of temporal input sequences in a cerebellar Purkinje cell model.Frontiers in cellular neuroscience · 2023Article
- Cerebellar transcranial magnetic stimulation in psychotic disorders: intermittent, continuous, and sham theta-burst stimulation on time perception and symptom severity.Frontiers in psychiatry · 2023Article
- Synaptic basis of a sub-second representation of time in a neural circuit model.Nature communications · 2022Article
- Article
- Understanding the physical basis of memory: Molecular mechanisms of the engram.The Journal of biological chemistry · 2022Review
- Quantitative properties of the creation and activation of a cell-intrinsic duration-encoding engram.Frontiers in computational neuroscience · 2022Article
- Transcranial direct current stimulation of cerebellum alters spiking precision in cerebellar cortex: A modeling study of cellular responses.PLoS computational biology · 2021Article
- Adaptive Prediction for Social Contexts: The Cerebellar Contribution to Typical and Atypical Social Behaviors.Annual review of neuroscience · 2021Article
15 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The standard view of the mechanisms underlying learning is that they involve strengthening or weakening synaptic connections. Learned response timing is thought to combine such plasticity with temporally patterned inputs to the neuron. We show here that a cerebellar Purkinje cell in a ferret can learn to respond to a specific input with a temporal pattern of activity consisting of temporally specific increases and decreases in firing over hundreds of milliseconds without a temporally patterned input. Training Purkinje cells with direct stimulation of immediate afferents, the parallel fibers, and pharmacological blocking of interneurons shows that the timing mechanism is intrinsic to the cell itself. Purkinje cells can learn to respond not only with increased or decreased firing but also with an adaptively timed activity pattern.
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