Evidence map›Paper›PMID 25267639›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2014

Resting-state networks link invasive and noninvasive brain stimulation across diverse psychiatric and neurological diseases.

Michael D Fox, Randy L Buckner, Hesheng Liu, M Mallar Chakravarty, Andres M Lozano, Alvaro Pascual-Leone

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03737032 (Theta Burst Stimulation in Young Adults With Depression), which is not on this map. Cited by 331 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
331citing papers in PubMed, 13 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03737032 nacompletednot on this mapstarted 2020, after this paper: background citation

Theta Burst Stimulation in Young Adults With Depression

TypeinterventionalSponsorErika ForbesRan2020 to 2022Enrolled29ConditionsDepressionArmsIntermittent Theta Burst Stimulation, Continuous Theta Burst Stimulation, Sham Theta Burst Stimulation
3 · Its place in the literature

Who cites it

331 citing papers in PubMed, 13 syntheses or guidelines pooled it.

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  5. Brain stimulation targets for chronic pain: Insights from meta-analysis, functional connectivity and literature review.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024
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  12. Invasive and Non-invasive Neurostimulation for OCD.Current topics in behavioral neurosciences · 2021
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  19. From rest to focus: pharmacological modulation of the relationship between resting state dorsal attention network dynamics and task-based brain activation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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271 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Michael D FoxBerenson-Allen Center for Noninvasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114; Athinoula A. Martinos Center for Biomedical Imaging, Harvard Medical School, Boston, MA 02129; foxmdphd@gmail.com.
Randy L BucknerAthinoula A. Martinos Center for Biomedical Imaging, Harvard Medical School, Boston, MA 02129; Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114; Department of Psychology, Center for Brain Science, Harvard University, Cambridge, MA 02138;
Hesheng LiuAthinoula A. Martinos Center for Biomedical Imaging, Harvard Medical School, Boston, MA 02129;
M Mallar ChakravartyCerebral Imaging Centre, Douglas Mental Health Institute, Verdun, QC, Canada H4H 1R3; Departments of Psychiatry and Biomedical Engineering, McGill University, Montreal, QC, Canada H3A 2B4;
Andres M LozanoDivision of Neurosurgery, Department of Surgery, Toronto Western Hospital, Toronto, ON, Canada M5T 2S8; and Krembil Neuroscience Center, University of Toronto, Toronto, ON, Canada M5T 2S8.
Alvaro Pascual-LeoneBerenson-Allen Center for Noninvasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215;

Funding

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
THE ROLE OF ADVANCED CAA IN ALZHEIMER'S DEMENTIAP50AG005134 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI HYMAN, BRADLEY T. · 1985 to 2018
$42.1M
Research Education ComponentP30AG062421 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI STEVEN E ARNOLD · 2019 to 2026
$36.5M
Transcranial Direct Current Stimulation and Robotic Training in Chronic StrokeR01HD069776 · NICHD · WINIFRED MASTERSON BURKE MED RES INST · PI EDWARDS, DYLAN JAMES · 2012 to 2016
$3.2M
Cortical connectivity, physiology, and response to stimulation in human epilepsyR01NS073601 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI CHANG, BERNARD S. · 2011 to 2015
$1.9M
Use of Resting-State Networks to Predict the Ideal Site for Brain StimulationK23NS083741 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI FOX, MICHAEL D · 2013 to 2017
$980k
Task-free Presurgical Evaluation of Lateral, Eloquent Cortex & Epileptic FociK25NS069805 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI LIU, HESHENG · 2011 to 2015
$895k
Role of functional brain connectivity on efficacy of TMS for depressionR21MH099196 · NIMH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI PASCUAL-LEONE, ALVARO · 2013 to 2014
$491k
Cortical plasticity in type II diabetes mellitusR21NS082870 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI PASCUAL-LEONE, ALVARO · 2013 to 2014
$490k
Transcranial Stimulation in Spino-Cerebellar AtaxiaR21NS085491 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI PASCUAL-LEONE, ALVARO · 2013 to 2014
$469k
TEMPERATURE-SENSITIVE GNRH CELL LINESF32HD007616 · NICHD · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI MOENTER, SUZANNE M · 1992 to 1994
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NCRR NIH HHS UL1 RR025758NIA NIH HHS P30 AG062421NIA NIH HHS P50 AG005134NICHD NIH HHS R01 HD069776NICHD NIH HHS R01HD069776NICHD NIH HHS R21HD07616NIMH NIH HHS R21 MH099196NIMH NIH HHS R21MH099196NINDS NIH HHS K23 NS083741NINDS NIH HHS K23NS083741NINDS NIH HHS K25 NS069805NINDS NIH HHS R01 NS073601NINDS NIH HHS R01NS073601NINDS NIH HHS R21 NS082870NINDS NIH HHS R21NS082870NINDS NIH HHS R21 NS085491NINDS NIH HHS R21NS085491
6 · The paper itself

Abstract

Brain stimulation, a therapy increasingly used for neurological and psychiatric disease, traditionally is divided into invasive approaches, such as deep brain stimulation (DBS), and noninvasive approaches, such as transcranial magnetic stimulation. The relationship between these approaches is unknown, therapeutic mechanisms remain unclear, and the ideal stimulation site for a given technique is often ambiguous, limiting optimization of the stimulation and its application in further disorders. In this article, we identify diseases treated with both types of stimulation, list the stimulation sites thought to be most effective in each disease, and test the hypothesis that these sites are different nodes within the same brain network as defined by resting-state functional-connectivity MRI. Sites where DBS was effective were functionally connected to sites where noninvasive brain stimulation was effective across diseases including depression, Parkinson's disease, obsessive-compulsive disorder, essential tremor, addiction, pain, minimally conscious states, and Alzheimer's disease. A lack of functional connectivity identified sites where stimulation was ineffective, and the sign of the correlation related to whether excitatory or inhibitory noninvasive stimulation was found clinically effective. These results suggest that resting-state functional connectivity may be useful for translating therapy between stimulation modalities, optimizing treatment, and identifying new stimulation targets. More broadly, this work supports a network perspective toward understanding and treating neuropsychiatric disease, highlighting the therapeutic potential of targeted brain network modulation.

Indexed as

Deep Brain StimulationRestBrainHumansMental DisordersNerve NetNervous System Diseasesclinical applicationhuman connectome projectneurosurgerytDCSTMS

Identifiers

PMID25267639
PMCPMC4205651

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.