ArticleProceedings of the National Academy of Sciences of the United States of America2014
Probing biological nanotopology via diffusion of weakly constrained plasmonic nanorods with optical coherence tomography.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 54 citations in OpenAlex.
- Review of dynamic optical coherence tomography for intracellular motility: signals, metrics, and their applications [Invited].Biomedical optics express · 2025Review
- Optical coherence tomography for noninvasive monitoring of drug delivery.Advanced drug delivery reviews · 2025Review
- Compressed intracellular motility via non-uniform temporal sampling in dynamic optical coherence tomography.Journal of biomedical optics · 2024Article
- Article
- Molecular Contrast Optical Coherence Tomography and Its Applications in Medicine.International journal of molecular sciences · 2022Review
- Spectral- and Polarization-Dependent Scattering of Gold Nanobipyramids for Exogenous Contrast in Optical Coherence Tomography.Nano letters · 2021Article
- OCT particle tracking velocimetry of biofluids in a microparallel plate strain induction chamber.Journal of biomedical optics · 2021Article
- Nanomotors Sense Local Physicochemical Heterogeneities in Tumor Microenvironments*.Angewandte Chemie (International ed. in English) · 2020Article
- Cholesterol-tuned liposomal membrane rigidity directs tumor penetration and anti-tumor effect.Acta pharmaceutica Sinica. B · 2019Article
- Photothermal Optical Coherence Tomography of Anti-Angiogenic Treatment in the Mouse Retina Using Gold Nanorods as Contrast Agents.Translational vision science & technology · 2019Article
- Light-responsive nanomedicine for biophotonic imaging and targeted therapy.Advanced drug delivery reviews · 2019Review
- Diffusion tensor optical coherence tomography.Physics in medicine and biology · 2018Article
- Direct monitoring of pulmonary disease treatment biomarkers using plasmonic gold nanorods with diffusion-sensitive OCT.Nanoscale · 2017Article
- Intracellular nanoparticle dynamics affected by cytoskeletal integrity.Soft matter · 2017Article
- Particle-Tracking Microrheology Using Micro-Optical Coherence Tomography.Biophysical journal · 2016Article
- Modeling and Simulation of Mucus Flow in Human Bronchial Epithelial Cell Cultures - Part I: Idealized Axisymmetric Swirling Flow.PLoS computational biology · 2016Article
- High-resolution contrast-enhanced optical coherence tomography in mice retinae.Journal of biomedical optics · 2016Article
- Imaging Extracellular Matrix Remodeling In Vitro by Diffusion-Sensitive Optical Coherence Tomography.Biophysical journal · 2016Article
- Contrast-enhanced optical coherence tomography with picomolar sensitivity for functional in vivo imaging.Scientific reports · 2016Article
- Diffusion-sensitive optical coherence tomography for real-time monitoring of mucus thinning treatments.Proceedings of SPIE--the International Society for Optical Engineering · 2016Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Biological materials exhibit complex nanotopology, i.e., a composite liquid and solid phase structure that is heterogeneous on the nanoscale. The diffusion of nanoparticles in nanotopological environments can elucidate biophysical changes associated with pathogenesis and disease progression. However, there is a lack of methods that characterize nanoprobe diffusion and translate easily to in vivo studies. Here, we demonstrate a method based on optical coherence tomography (OCT) to depth-resolve diffusion of plasmon-resonant gold nanorods (GNRs) that are weakly constrained by the biological tissue. By using GNRs that are on the size scale of the polymeric mesh, their Brownian motion is minimally hindered by intermittent collisions with local macromolecules. OCT depth-resolves the particle-averaged translational diffusion coefficient (DT) of GNRs within each coherence volume, which is separable from the nonequilibrium motile activities of cells based on the unique polarized light-scattering properties of GNRs. We show how this enables minimally invasive imaging and monitoring of nanotopological changes in a variety of biological models, including extracellular matrix (ECM) remodeling as relevant to carcinogenesis, and dehydration of pulmonary mucus as relevant to cystic fibrosis. In 3D ECM models, DT of GNRs decreases with both increasing collagen concentration and cell density. Similarly, DT of GNRs is sensitive to human bronchial-epithelial mucus concentration over a physiologically relevant range. This novel method comprises a broad-based platform for studying heterogeneous nanotopology, as distinct from bulk viscoelasticity, in biological milieu.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.