ArticleProceedings of the National Academy of Sciences of the United States of America2014
Vasoprotective effect of PDGF-CC mediated by HMOX1 rescues retinal degeneration.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 39 citations in OpenAlex.
- An Inhibitory Aptamer Against PDGF-C Overcomes Anti-VEGF Refractoriness and Reduces Choroidal Neovascularization and Fibrosis.Investigative ophthalmology & visual science · 2026Article
- Effect of Platelet-Derived Growth Factor C on Mitochondrial Oxidative Stress Induced by High d-Glucose in Human Aortic Endothelial Cells.Pharmaceuticals (Basel, Switzerland) · 2022Article
- High dose expression of heme oxigenase-1 induces retinal degeneration through ER stress-related DDIT3.Molecular neurodegeneration · 2021Article
- Hyperdry human amniotic membrane application as a wound dressing for a full-thickness skin excision after a third-degree burn injury.Burns & trauma · 2020Article
- Bcl-6-directed follicular helper T cells promote vascular inflammatory injury in diabetic retinopathy.Theranostics · 2020Article
- Acute Treatment With Gleevec Does Not Promote Early Vascular Recovery Following Intracerebral Hemorrhage in Adult Male Rats.Frontiers in neuroscience · 2020Article
- General Study and Gene Expression Profiling of Endotheliocytes Cultivated on Electrospun Materials.Materials (Basel, Switzerland) · 2019Article
- PDGF/PDGFR axis in the neural systems.Molecular aspects of medicine · 2018Review
- The role of myeloid cell-derived PDGF-B in neotissue formation in a tissue-engineered vascular graft.Regenerative medicine · 2017Article
- Microglia Polarization with M1/M2 Phenotype Changes in rd1 Mouse Model of Retinal Degeneration.Frontiers in neuroanatomy · 2017Article
- PDGF-CC underlies resistance to VEGF-A inhibition and combinatorial targeting of both suppresses pathological angiogenesis more efficiently.Oncotarget · 2016Article
- Co-option of pre-existing vascular beds in adipose tissue controls tumor growth rates and angiogenesis.Oncotarget · 2016Article
- TLR2/4 deficiency prevents oxygen-induced vascular degeneration and promotes revascularization by downregulating IL-17 in the retina.Scientific reports · 2016Article
- Vasoregression: A Shared Vascular Pathology Underlying Macrovascular And Microvascular Pathologies?Omics : a journal of integrative biology · 2015Review
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Authors and funding
23 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Blood vessel degeneration is critically involved in nearly all types of degenerative diseases. Therefore strategies to enhance blood vessel protection and survival are highly needed. In this study, using different animal models and cultured cells, we show that PDGF-CC is a potent vascular protective and survival factor. PDGF-CC deficiency by genetic deletion exacerbated blood vessel regression/degeneration in various animal models. Importantly, treatment with PDGF-CC protein not only increased the survival of retinal blood vessels in a model of oxygen-induced blood vessel regression but also markedly rescued retinal and blood vessel degeneration in a disease model of retinitis pigmentosa. Mechanistically, we revealed that heme oxygenase-1 (HMOX1) activity is critically required for the vascular protective/survival effect of PDGF-CC, because blockade of HMOX1 completely abolished the protective effect of PDGF-CC in vitro and in vivo. We further found that both PDGF receptors, PDGFR-β and PDGFR-α, are required for the vasoprotective effect of PDGF-CC. Thus our data show that PDGF-CC plays a pivotal role in maintaining blood vessel survival and may be of therapeutic value in treating various types of degenerative diseases.
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