ArticleProceedings of the National Academy of Sciences of the United States of America2014
Bacterial quorum sensing and metabolic slowing in a cooperative population.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed, 148 citations in OpenAlex.
- A global stress alarmone couples nutrient limitation to suppression of social signaling in bacteria.iScience · 2026Article
- Genetic variation and proliferation-promoting virulence function of thymidine kinase from Paulownia witches' broom phytoplasma.BMC plant biology · 2026Article
- Microbial communication in saline environments: quorum sensing and the future of anaerobic wastewater treatment.BMC biology · 2026Review
- Rethinking Microbial Chemical Ecology: Secondary Metabolites as Concentration-Dependent Signaling Hubs with Implications for Anti-Virulence Intervention.Microorganisms · 2026Review
- The Regulatory Role of Quorum Sensing-Mediated Amino Acid Metabolism in Biofilm Formation and Motility ofFoods (Basel, Switzerland) · 2026Article
- Boundary conditions for exploiting the cooperation ofApplied and environmental microbiology · 2025Article
- The acquisition of additional control over quorum sensing regulation reduces the variability of final cell density in Burkholderia.Communications biology · 2025Article
- The role of bacterial metabolism in antimicrobial resistance.Nature reviews. Microbiology · 2025Review
- Phage-host interaction inApplied and environmental microbiology · 2025Article
- Quorum Sensing Coordinates Carbon and Nitrogen Metabolism to Optimize Public Goods Production in Pseudomonas fluorescens 2P24.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Article
- Less is more: the lack of autoinducer-2-dependent quorum sensing promotes competitive fitness ofFrontiers in cellular and infection microbiology · 2025Article
- Unraveling metabolic reprogramming inFrontiers in molecular biosciences · 2025Article
- Biomass competition connects individual and community scaling patterns.Nature communications · 2024Article
- qsmR encoding an IclR-family transcriptional factor is a core pathogenic determinant of Burkholderia glumae beyond the acyl-homoserine lactone-mediated quorum-sensing system.PLoS pathogens · 2024Article
- Impact of Quorum Sensing on the Virulence and Survival Traits ofPlants (Basel, Switzerland) · 2024Article
- Soybean-mediated suppression of BjaI/BjaRApplied and environmental microbiology · 2024Article
- Citrate cross-feeding bymBio · 2024Article
- Control of bacterial quorum threshold for metabolic homeostasis and cooperativity.Microbiology spectrum · 2024Article
- Perturbation of Quorum Sensing after the Acquisition of Bacteriophage Resistance Could Contribute to Novel Traits inMicroorganisms · 2023Article
2 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acyl-homoserine lactone (AHL)-mediated quorum sensing (QS) controls the production of numerous intra- and extracellular products across many species of Proteobacteria. Although these cooperative activities are often costly at an individual level, they provide significant benefits to the group. Other potential roles for QS include the restriction of nutrient acquisition and maintenance of metabolic homeostasis of individual cells in a crowded but cooperative population. Under crowded conditions, QS may function to modulate and coordinate nutrient utilization and the homeostatic primary metabolism of individual cells. Here, we show that QS down-regulates glucose uptake, substrate level and oxidative phosphorylation, and de novo nucleotide biosynthesis via the activity of the QS-dependent transcriptional regulator QsmR (quorum sensing master regulator R) in the rice pathogen Burkholderia glumae. Systematic analysis of glucose uptake and core primary metabolite levels showed that QS deficiency perturbed nutrient acquisition, and energy and nucleotide metabolism, of individuals within the group. The QS mutants grew more rapidly than the wild type at the early exponential stage and outcompeted wild-type cells in coculture. Metabolic slowing of individuals in a QS-dependent manner indicates that QS acts as a metabolic brake on individuals when cells begin to mass, implying a mechanism by which AHL-mediated QS might have evolved to ensure homeostasis of the primary metabolism of individuals under crowded conditions.
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