Evidence map›Paper›PMID 25267606›Full record

ArticleDrug and alcohol dependence2014

Is residential treatment effective for opioid use disorders? A longitudinal comparison of treatment outcomes among opioid dependent, opioid misusing, and non-opioid using emerging adults with substance use disorder.

Zev Schuman-Olivier, M Claire Greene, Brandon G Bergman, John F Kelly

Abstract readComparative Study
In one paragraph

Article in Drug and alcohol dependence, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 42 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Zev Schuman-OlivierHarvard Medical School, Department of Psychiatry, United States; Massachusetts General Hospital, United States; Cambridge Health Alliance, United States. Electronic address: zschuman@cha.harvard.edu.
M Claire GreeneMassachusetts General Hospital, United States.
Brandon G BergmanHarvard Medical School, Department of Psychiatry, United States; Massachusetts General Hospital, United States.
John F KellyHarvard Medical School, Department of Psychiatry, United States; Massachusetts General Hospital, United States.
Harvard University · USCambridge Health Alliance · USMassachusetts General Hospital · US

Funding

NIDA Epidemiology Training Program: Johns Hopkins UniversityT32DA007292 · NIDA · JOHNS HOPKINS UNIVERSITY · PI RENEE M. JOHNSON, Brion S Maher · 1993 to 2026
$17.7M
MECHANISMS AND MODERATORS OF CHANGE AMONG YOUTH TREATED FOR ALCOHOL USE DISORDERSR21AA018185 · NIAAA · MASSACHUSETTS GENERAL HOSPITAL · PI KELLY, JOHN F. · 2010 to 2011
$481k
NIAAA NIH HHS R21 AA018185NIAAA NIH HHS R21AA018185-02NIDA NIH HHS T32 DA007292
6 · The paper itself

Abstract

backgroundOpioid misuse and dependence rates among emerging adults have increased substantially. While office-based opioid treatments (e.g., buprenorphine/naloxone) have shown overall efficacy, discontinuation rates among emerging adults are high. Abstinence-based residential treatment may serve as a viable alternative, but has seldom been investigated in this age group.

methodsEmerging adults attending 12-step-oriented residential treatment (N=292; 18-24 years, 74% male, 95% White) were classified into opioid dependent (OD; 25%), opioid misuse (OM; 20%), and no opiate use (NO; 55%) groups. Paired t-tests and ANOVAs tested baseline differences and whether groups differed in their during-treatment response. Longitudinal multilevel models tested whether groups differed on substance use outcomes and treatment utilization during the year following the index treatment episode.

resultsDespite a more severe clinical profile at baseline among OD, all groups experienced similar during-treatment increases on therapeutic targets (e.g., abstinence self-efficacy), while OD showed a greater decline in psychiatric symptoms. During follow-up relative to OM, both NO and OD had significantly greater Percent Days Abstinent, and significantly less cannabis use. OD attended significantly more outpatient treatment sessions than OM or NO; 29% of OD was completely abstinent at 12-month follow-up.

conclusionsFindings here suggest that residential treatment may be helpful for emerging adults with opioid dependence. This benefit may be less prominent, though, among non-dependent opioid misusers. Randomized trials are needed to compare more directly the relative benefits of outpatient agonist-based treatment to abstinence-based, residential care in this vulnerable age-group, and to examine the feasibility of an integrated model.

Indexed as

AdolescentAnalgesics, OpioidBuprenorphineFemaleFollow-Up StudiesHumansLongitudinal StudiesMaleNaloxoneNarcotic AntagonistsOpioid-Related DisordersResidential TreatmentSubstance-Related DisordersTreatment OutcomeYoung AdultAnalgesics, OpioidBuprenorphineNaloxoneNarcotic Antagonists12-Step residentialAbstinenceEmerging adultOffice-based opioid treatmentOpioid dependenceYouth

Identifiers

PMID25267606
PMCPMC4253677
OpenAlexW2069268779

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.