Observational studyJournal of clinical monitoring and computing2015
Reliability of a new 4th generation FloTrac algorithm to track cardiac output changes in patients receiving phenylephrine.
Observational study in Journal of clinical monitoring and computing, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Hypotension prediction index guided versus conventional goal directed therapy to reduce intraoperative hypotension during thoracic surgery: a randomized trial.BMC anesthesiology · 2023Trial
- Effects of dobutamine and phenylephrine on cerebral perfusion in patients undergoing cerebral bypass surgery: a randomised crossover trial.British journal of anaesthesia · 2020Trial
- Trial
- Comparison of cardiac index values between bioimpedance and pulse contour analysis in patients undergoing cardiac surgery under cardiopulmonary bypass.Indian journal of anaesthesia · 2026Article
- Trendelenburg maneuver to predict fluid responsiveness in patients under mechanical ventilation with spontaneous breathing: a prospective study.BMC anesthesiology · 2026Article
- Effects of Phenylephrine Administration on the Circulatory Dynamics of Patients with Hypotension Due to Bleeding During Surgery, Specifically Left Ventricular End-Diastolic Volume, Effective Arterial Elastance, and Left Ventricular End-Systolic Elastance.Journal of clinical medicine · 2026Article
- Comparison of noninvasive cardiac output and stroke volume measurements using electrical impedance tomography with invasive methods in a swine model.Scientific reports · 2024Article
- Prediction of Fluid Responsiveness Using Combined End-Expiratory and End-Inspiratory Occlusion Tests in Cardiac Surgical Patients.Journal of clinical medicine · 2023Article
- The Cardiac Power Index during Abdominal Open Aortic Surgery: Intraoperative Insights into the Cardiac Performance-A Retrospective Observational Analysis.Journal of personalized medicine · 2022Article
- Four different methods of measuring cardiac index during cytoreductive surgery and hyperthermic intraperitoneal chemotherapy.Korean journal of anesthesiology · 2021Article
- Comparison the accuracy and trending ability of cardiac index measured by the fourth- generation of FloTrac with the PiCCO device in septic shock patientsTurkish journal of medical sciences · 2020Article
- The value of a superior vena cava collapsibility index measured with a miniaturized transoesophageal monoplane continuous echocardiography probe to predict fluid responsiveness compared to stroke volume variations in open major vascular surgery: a prospective cohort study.Journal of clinical monitoring and computing · 2020Article
- The accuracy and trending ability of cardiac index measured by the fourth-generation FloTrac/Vigileo system™ and the Fick method in cardiac surgery patients.Journal of clinical monitoring and computing · 2019Observational
- Evaluation of the use of the fourth version FloTrac system in cardiac output measurement before and after cardiopulmonary bypass.Journal of clinical monitoring and computing · 2018Article
- Accuracy and trending ability of the fourth-generation FloTrac/Vigileo System™ in patients undergoing abdominal aortic aneurysm surgery.Journal of anesthesia · 2018Article
- Phenylephrine increases near-infrared spectroscopy determined muscle oxygenation in men.Journal of clinical monitoring and computing · 2017Article
- Comparison of cardiac output measures by transpulmonary thermodilution, pulse contour analysis, and pulmonary artery thermodilution during off-pump coronary artery bypass surgery: a subgroup analysis of the cardiovascular anaesthesia registry at a single tertiary centre.Journal of clinical monitoring and computing · 2016Observational
- Journal of Clinical Monitoring and Computing 2015 end of year summary: cardiovascular and hemodynamic monitoring.Journal of clinical monitoring and computing · 2016Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Phenylephrine is often used to treat intra-operative hypotension. Previous studies have shown that the FloTrac cardiac monitor may overestimate cardiac output (CO) changes following phenylephrine administration. A new algorithm (4th generation) has been developed to improve performance in this setting. We performed a prospective observational study to assess the effects of phenylephrine administration on CO values measured by the 3rd and 4th generation FloTrac algorithms. 54 patients were enrolled in this study. We used the Nexfin, a pulse contour method shown to be insensitive to vasopressor administration, as the reference method. Radial arterial pressures were recorded continuously in patients undergoing surgery. Phenylephrine administration times were documented. Arterial pressure recordings were subsequently analyzed offline using three different pulse contour analysis algorithms: FloTrac 3rd generation (G3), FloTrac 4th generation (G4), and Nexfin (nf). One minute of hemodynamic measurements was analyzed immediately before phenylephrine administration and then repeated when the mean arterial pressure peaked. A total of 157 (4.6 ± 3.2 per patient, range 1-15) paired sets of hemodynamic recordings were analyzed. Phenylephrine induced a significant increase in stroke volume (SV) and CO with the FloTrac G3, but not with FloTrac G4 or Nexfin algorithms. Agreement between FloTrac G3 and Nexfin was: 0.23 ± 1.19 l/min and concordance was 51.1%. In contrast, agreement between FloTrac G4 and Nexfin was: 0.19 ± 0.86 l/min and concordance was 87.2%. In conclusion, the pulse contour method of measuring CO, as implemented in FloTrac 4th generation algorithm, has significantly improved its ability to track the changes in CO induced by phenylephrine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.