ArticleBMC infectious diseases2014
Bordetella pertussis: an underreported pathogen in pediatric respiratory infections, a prospective cohort study.
Article in BMC infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03233516 (Trial of Respiratory Infections in Children for Enhanced Diagnostics), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Trial of Respiratory Infections in Children for Enhanced Diagnostics
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Prevalence of Atypical Pathogens in Patients With Cough and Community-Acquired Pneumonia: A Meta-Analysis.Annals of family medicine · 2016Pooled it
- Population-Based Pertussis Incidence and Risk Factors in Infants Less Than 6 Months in Nepal.Journal of the Pediatric Infectious Diseases Society · 2017Trial
- Population-Based Study of Pertussis Incidence and Risk Factors among Persons >50 Years of Age, Australia.Emerging infectious diseases · 2024Observational
- Assessment of Pertussis Underreporting in Italy.Journal of clinical medicine · 2023Article
- Article
- Pertussis in early life: underdiagnosed, severe, and risky disease. A seven-year experience in a pediatric tertiary-care hospital.Human vaccines & immunotherapeutics · 2021Article
- The clinical application of Filmarray respiratory panel in children especially with severe respiratory tract infections.BMC infectious diseases · 2021Article
- Tracheal colonization factor A (TcfA) is a biomarker for rapid and specific detection of Bordetella pertussis.Scientific reports · 2020Article
- Identification of etiologic agents and clinical characteristics for patients suspected of having pertussis in a large Children's Hospital in China.Annals of translational medicine · 2019Article
- Introducing a New Algorithm for Classification of Etiology in Studies on Pediatric Pneumonia: Protocol for the Trial of Respiratory Infections in Children for Enhanced Diagnostics Study.JMIR research protocols · 2019Article
- Identfication of viral and bacterial etiologic agents of the pertussis-like syndrome in children under 5 years old hospitalized.BMC infectious diseases · 2019Article
- Single- and multiple viral respiratory infections in children: disease and management cannot be related to a specific pathogen.BMC infectious diseases · 2017Article
- Pertussis-Associated Pneumonia in Infants and Children From Low- and Middle-Income Countries Participating in the PERCH Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016Article
- Bordetella pertussis Infection in South African HIV-Infected and HIV-Uninfected Mother-Infant Dyads: A Longitudinal Cohort Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016Article
- Pertussis in infants: an underestimated disease.BMC infectious diseases · 2016Article
- Pertussis: Microbiology, Disease, Treatment, and Prevention.Clinical microbiology reviews · 2016Review
- Factors Associated with Time to Appropriate Treatment in Pertussis Cases in Georgia, 2009 to 2013.Antimicrobial agents and chemotherapy · 2016Article
- High prevalence of Bordetella pertussis in children under 5 years old hospitalized with acute respiratory infections in Lima, Peru.BMC infectious diseases · 2015Article
- Characteristics of Hospitalized Cases of Pertussis in Catalonia and Navarra, Two Regions in the North of Spain.PloS one · 2015Article
Corrections and comments
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Authors and funding
5 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe incidence of pertussis has been increasing worldwide. In the Netherlands, the seroprevalence has risen higher than the reported cases, suggesting that laboratory tests for pertussis are considered infrequently and that even more pertussis cases are missed. The objective of our study was to determine the frequency of pertussis in clinically unsuspect cases compared to suspect cases with the intention of finding clinical predictors.
methodsThe present prospective cohort study was part of a controlled clinical trial evaluating the impact of molecular diagnostics on clinical decision making in pediatric respiratory infections, performed during 2 winter seasons. For this study, in the first season pertussis was only tested in case of clinical suspicion, in the second season, pertussis was also tested without clinical suspicion. Multivariate and univariate analysis were performed using SPSS 18 and Statistical software 'R'.
resultsIn the two seasons respectively 22/209 (10,5%) and 49/373 (13,1%) cases were clinically suspected of pertussis. Bordetella pertussis was detected by real time RT-PCR in respectively 2/22 (9,1%) and 7/49 (14,3%) cases. In the second season an additional 7 cases of pertussis were found in clinically unsuspected cases (7/257 = 2,7%). These additional cases didn't differ in clinical presentation from children without a positive test for pertussis with respect to respiratory symptoms.
conclusionsPertussis in children sometimes mimics viral respiratory tract infections. If pertussis diagnostics are based on clinical suspicion alone, about 1 in 5 cases (19%) is missed. Despite widely accepted clinical criteria, paroxysmal cough is not a good predictor of pertussis. To prevent spreading, physicians should include B. pertussis in routine diagnostics in respiratory tract infections.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.