ArticleInternational orthopaedics2014
Bone morphogenetic protein and orthopaedic surgery: can we legitimate its off-label use?
Article in International orthopaedics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Bone morphogenetic protein use in spine surgery-complications and outcomes: a systematic review.International orthopaedics · 2016Pooled it
- Safety and Efficacy of rhBMP-2 for Treating Acute Traumatic Fractures of the Upper and Lower Extremities: A Multicenter Prospective Study.Journal of clinical medicine · 2026Article
- Pannexins in the musculoskeletal system: new targets for development and disease progression.Bone research · 2024Review
- Clinical compatibility of magnetic resonance imaging with magnetic intramedullary nails: a feasibility study.Archives of orthopaedic and trauma surgery · 2024Article
- Safety and Efficacy of Stand-Alone Bioactive Glass Injectable Putty or Granules in Posterior Vertebral Fusion for Adolescent Idiopathic and Non-Idiopathic Scoliosis.Children (Basel, Switzerland) · 2023Article
- The use of heparin/polycation coacervate sustain release system to compare the bone regenerative potentials of 5 BMPs using a critical sized calvarial bone defect model.Biomaterials · 2022Article
- Biofabrication of SDF-1 Functionalized 3D-Printed Cell-Free Scaffolds for Bone Tissue Regeneration.International journal of molecular sciences · 2020Article
- [Clinical administration of platelet-rich plasma and growth factors to the musculoskeletal system].Der Orthopade · 2019Article
- Bone morphogenetic proteins in fracture repair.International orthopaedics · 2018Review
- Heparin-dopamine functionalized graphene foam for sustained release of bone morphogenetic protein-2.Journal of tissue engineering and regenerative medicine · 2018Article
- Engineered Coatings for Titanium Implants To Present Ultralow Doses of BMP-7.ACS biomaterials science & engineering · 2018Article
- Bone grafts and biomaterials substitutes for bone defect repair: A review.Bioactive materials · 2017Review
- Marshall R. Urist and the discovery of bone morphogenetic proteins.International orthopaedics · 2017Article
- Bone morphogenetic protein-2 for the treatment of congenital pseudarthrosis of the tibia or persistent tibial nonunion in children and adolescents: A retrospective study with a minimum 2-year follow-up.Journal of materials science. Materials in medicine · 2017Article
- BBP-Functionalized Biomimetic Nanofibrous Scaffold Can Capture BMP2 and Promote Osteogenic Differentiation.Journal of materials chemistry. B · 2017Article
- Recombinant Human Bone Morphogenetic Protein-2 (rhBMP-2) for the Treatment of Nonunion of the Femur in Children and Adolescents: A Retrospective Analysis.BioMed research international · 2017Article
- Bone morphogenetic protein-7: Review of signalling and efficacy in fracture healing.Journal of orthopaedic translation · 2016Review
- Biological aspects of segmental bone defects management.International orthopaedics · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeBone morphogenetic proteins (BMP) are recombinant osteoinductive proteins with their primary role being to promote bone formation. The off-label use of BMP in orthopaedic surgery has dramatically increased. However, reports of complications with BMP have emerged, and the safety of these proteins in orthopaedics is questioned. The purpose of this review was to evaluate safe situations in which BMP should be used and situations in which their use should be restricted.
methodWe recorded all studies from PubMed database from 2002 (date of first authorisation for both BMPs) until January 2014 using "BMP" or "bone morphogenetic protein". Then we screened and extracted all studies dealing with orthopaedic surgery. All situations in which BMP were used, even cases reports, were considered, and complications reported were then listed.
resultsSituations in which it seems safe and efficient to use BMP are long-bone nonunions, or arthrodesis as an alternative or combined to autograft in small-bone loss. Surgeons and patients should be aware of transient aseptic wound swelling when BMP is located superficially. The use of BMP in spine surgery for intersomatic fusion is efficient but should be restricted to approaches that respect the vertebral canal to avoid neurological complications.
conclusionThis review is an off-label map of BMP use in orthopaedics during the past 10 years. Our results could provide a useful tool to help decisions around when to use a BMP in a specific complex, and sometimes off-label, situation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.