Evidence map›Paper›PMID 25267414›Full record

ArticleApplied psychophysiology and biofeedback2014

Neuromodulation integrating rTMS and neurofeedback for the treatment of autism spectrum disorder: an exploratory study.

Estate M Sokhadze, Ayman S El-Baz, Allan Tasman, Lonnie L Sears, Yao Wang, Eva V Lamina, Manuel F Casanova

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Applied psychophysiology and biofeedback, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 3 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 103 citations in OpenAlex.

  1. Pooled it
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  7. Article
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  11. Article
  12. The use of noninvasive brain stimulation techniques in autism spectrum disorder.Autism research : official journal of the International Society for Autism Research · 2024
    Article
  13. Article
  14. Review
  15. Looking Back at the Next 40 Years of ASD Neuroscience Research.Journal of autism and developmental disorders · 2021
    Review
  16. Article
  17. Effects of Non-invasive Neurostimulation on Autism Spectrum Disorder: A Systematic Review.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2020
    Review
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Estate M SokhadzeUniversity of Louisville, 401 E Chestnut Street, Suite 600, Louisville, KY, 40202, USA, tato.sokhadze@louisville.edu.
Ayman S El-Baz
Allan Tasman
Lonnie L Sears
Yao Wang
Eva V Lamina
Manuel F Casanova
University of Louisville Hospital · USUniversity of Louisville · US

Funding

Building a Selective Inhibitory Control Tone in Autism: An rTMS StudyR01MH086784 · NIMH · UNIVERSITY OF LOUISVILLE · PI CASANOVA, MANUEL F · 2009 to 2012
$884k
NIMH NIH HHS R01 MH086784NIMH NIH HHS R01 MH86784
6 · The paper itself

Abstract

Autism spectrum disorder (ASD) is a pervasive developmental disorder characterized by deficits in social interaction, language, stereotyped behaviors, and restricted range of interests. In previous studies low frequency repetitive transcranial magnetic stimulation (rTMS) has been used, with positive behavioral and electrophysiological results, for the experimental treatment in ASD. In this study we combined prefrontal rTMS sessions with electroencephalographic (EEG) neurofeedback (NFB) to prolong and reinforce TMS-induced EEG changes. The pilot trial recruited 42 children with ASD (~14.5 years). Outcome measures included behavioral evaluations and reaction time test with event-related potential (ERP) recording. For the main goal of this exploratory study we used rTMS-neurofeedback combination (TMS-NFB, N = 20) and waitlist (WTL, N = 22) groups to examine effects of 18 sessions of integrated rTMS-NFB treatment or wait period) on behavioral responses, stimulus and response-locked ERPs, and other functional and clinical outcomes. The underlying hypothesis was that combined TMS-NFB will improve executive functions in autistic patients as compared to the WTL group. Behavioral and ERP outcomes were collected in pre- and post-treatment tests in both groups. Results of the study supported our hypothesis by demonstration of positive effects of combined TMS-NFB neurotherapy in active treatment group as compared to control WTL group, as the TMS-NFB group showed significant improvements in behavioral and functional outcomes as compared to the WTL group.

Indexed as

AdolescentAdultBrain WavesChildChild Development Disorders, PervasiveEvoked PotentialsExecutive FunctionFemaleHumansMaleNeurofeedbackPilot ProjectsTranscranial Magnetic StimulationTreatment OutcomeYoung Adult

Identifiers

PMID25267414
PMCPMC4221494
OpenAlexW2084943861

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.