ArticleThe Plant journal : for cell and molecular biology2015
Metabolome-genome-wide association study dissects genetic architecture for generating natural variation in rice secondary metabolism.
Article in The Plant journal : for cell and molecular biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
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Who cites it
77 citing papers in PubMed.
- Metabolic reprogramming in plant defense: linking signaling networks to metabolomics-driven insights.Plant signaling & behavior · 2026Review
- From Phytochemical Characterization to Energy Metabolism-Driven Molecular Responses: The Anticancer Potential ofNutrients · 2026Article
- Genetic architecture of the tomato fruit lipidome.PNAS nexus · 2026Article
- Bridging scales: integrated multi-omics and deep phenotyping for climate resilience in crop plants.Frontiers in plant science · 2026Review
- Review
- Development of phytochemical genomics: From decoding metabolome to functional genomics and biotechnology of plant metabolism.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2025Review
- Metabolic plasticity and adaptive evolution inFrontiers in plant science · 2025Review
- Genome-wide association studies identify loci controlling specialized seed metabolites in Arabidopsis.Plant physiology · 2024Article
- Exploring the genetic architecture of specialized metabolism in Arabidopsis seeds.Plant physiology · 2024Article
- Metabolic GWAS-based dissection of genetic basis underlying nutrient quality variation and domestication of cassava storage root.Genome biology · 2023Article
- Chemical Structure Diversity and Extensive Biological Functions of Specialized Metabolites in Rice.International journal of molecular sciences · 2023Review
- Plant biochemical genetics in the multiomics era.Journal of experimental botany · 2023Review
- QT-GWAS: A novel method for unveiling biosynthetic loci affecting qualitative metabolic traits.Molecular plant · 2023Article
- Characterization of novel loci controlling seed oil content in Brassica napus by marker metabolite-based multi-omics analysis.Genome biology · 2023Article
- Exploring the Potential of Multiomics and Other Integrative Approaches for Improving Waterlogging Tolerance in Plants.Plants (Basel, Switzerland) · 2023Review
- Omics-driven exploration and mining of key functional genes for the improvement of food and fiber crops.Frontiers in plant science · 2023Review
- A metabolome genome-wide association study implicates histidineFrontiers in plant science · 2023Article
- Review
- Expanding the Coverage of Metabolic Landscape in Cultivated Rice with Integrated Computational Approaches.Genomics, proteomics & bioinformatics · 2022Article
- A Review of Integrative Omic Approaches for Understanding Rice Salt Response Mechanisms.Plants (Basel, Switzerland) · 2022Review
17 more citing papers are in PubMed but not listed here.
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8 authors.
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Abstract
Plants produce structurally diverse secondary (specialized) metabolites to increase their fitness for survival under adverse environments. Several bioactive compounds for new drugs have been identified through screening of plant extracts. In this study, genome-wide association studies (GWAS) were conducted to investigate the genetic architecture behind the natural variation of rice secondary metabolites. GWAS using the metabolome data of 175 rice accessions successfully identified 323 associations among 143 single nucleotide polymorphisms (SNPs) and 89 metabolites. The data analysis highlighted that levels of many metabolites are tightly associated with a small number of strong quantitative trait loci (QTLs). The tight association may be a mechanism generating strains with distinct metabolic composition through the crossing of two different strains. The results indicate that one plant species produces more diverse phytochemicals than previously expected, and plants still contain many useful compounds for human applications.
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