ArticleThe Journal of cell biology2014
A matrix metalloproteinase mediates long-distance attenuation of stem cell proliferation.
Article in The Journal of cell biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
48 citing papers in PubMed, 83 citations in OpenAlex.
- Article
- Matrix metalloproteinase 2 destabilizes Dally-like protein to restrict extracellular Wingless distribution.Molecular biology of the cell · 2025Article
- Regulation of somatic stem cell and niche precursor fates and proliferation of by Wnt, JAK-STAT, Hedgehog and Hippo/Yorkie pathways during Drosophila pupal ovary development resembles the signaling framework organizing adult stem cell behavior.bioRxiv : the preprint server for biology · 2025Article
- ETS transcription factors regulate precise matrix metalloproteinase expression and follicle rupture in Drosophila.Development (Cambridge, England) · 2024Article
- Spatial regulation of Drosophila ovarian Follicle Stem Cell division rates and cell cycle transitions.PLoS genetics · 2023Article
- Single-cell expression profile of Drosophila ovarian follicle stem cells illuminates spatial differentiation in the germarium.BMC biology · 2023Article
- Sequential events during the quiescence to proliferation transition establish patterns of follicle cell differentiation in the Drosophila ovary.Biology open · 2023Article
- Regulation of Wnt distribution and function by Drosophila glypicans.Journal of cell science · 2022Review
- Articulating the "stem cell niche" paradigm through the lens of non-model aquatic invertebrates.BMC biology · 2022Review
- Genome-Wide Analysis inGenes · 2022Article
- Investigating Adult Stem Cells Through Lineage analyses.Stem cell reviews and reports · 2022Review
- Characterization of preantral follicle clustering and neighborhood patterns in the equine ovary.PloS one · 2022Article
- Dysregulation of BMP, Wnt, and Insulin Signaling in Fragile X Syndrome.Frontiers in cell and developmental biology · 2022Review
- Canonical Wnt Signaling Promotes Formation of Somatic Permeability Barrier for Proper Germ Cell Differentiation.Frontiers in cell and developmental biology · 2022Article
- Glypican 4 mediates Wnt transport between germ layers via signaling filopodia.The Journal of cell biology · 2021Article
- Collective nuclear behavior shapes bilateral nuclear symmetry for subsequent left-right asymmetric morphogenesis in Drosophila.Development (Cambridge, England) · 2021Article
- Review
- Stem cell niche organization in the Drosophila ovary requires the ECM component Perlecan.Current biology : CB · 2021Article
- Extracellular spreading of Wingless is required for Drosophila oogenesis.PLoS genetics · 2021Article
- Article
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Ligand-based signaling can potentiate communication between neighboring cells and between cells separated by large distances. In the Drosophila melanogaster ovary, Wingless (Wg) promotes proliferation of follicle stem cells located ~50 µm or five cell diameters away from the Wg source. How Wg traverses this distance is unclear. We find that this long-range signaling requires Division abnormally delayed (Dally)-like (Dlp), a glypican known to extend the range of Wg ligand in the wing disc by binding Wg. Dlp-mediated spreading of Wg to follicle stem cells is opposed by the extracellular protease Mmp2, which cleaved Dlp in cell culture, triggering its relocalization such that Dlp no longer contacted Wg protein. Mmp2-deficient ovaries displayed increased Wg distribution, activity, and stem cell proliferation. Mmp2 protein is expressed in the same cells that produce Wg; thus, niche cells produce both a long-range stem cell proliferation factor and a negative regulator of its spreading. This system could allow for spatial control of Wg signaling to targets at different distances from the source.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.