ArticleBMC infectious diseases2014
Clostridium difficile carriage in hospitalized cancer patients: a prospective investigation in eastern China.
Article in BMC infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- The emergence of Clostridium difficile infection in Asia: A systematic review and meta-analysis of incidence and impact.PloS one · 2017Pooled it
- The incidence and drug resistance of Clostridium difficile infection in Mainland China: a systematic review and meta-analysis.Scientific reports · 2016Pooled it
- Molecular epidemiology ofMicrobiology spectrum · 2026Article
- The Ambivalent Nature ofToxins · 2025Review
- Risk factors and outcomes of Clostridioides difficile infection in patients with colorectal cancer: critical perspective in management.Gut pathogens · 2025Review
- Outcomes ofEuropean journal of hospital pharmacy : science and practice · 2022Article
- Prospective Multicenter Study of Chemotherapy-InducedFrontiers in oncology · 2021Article
- Molecular characteristics of Clostridium difficile in children with acute gastroenteritis from Zhejiang.BMC infectious diseases · 2020Article
- Clostridium difficile-associated Diarrhea in Developing Countries: A Systematic Review and Meta-Analysis.Infectious diseases and therapy · 2019Article
- Different molecular characteristics and antimicrobial resistance profiles ofEmerging microbes & infections · 2019Article
- The rate and importance ofGastroenterology and hepatology from bed to bench · 2019Article
- Simultaneous detection and characterization of toxigenic Clostridium difficile directly from clinical stool specimens.Frontiers of medicine · 2018Article
- Molecular epidemiology ofInfection and drug resistance · 2018Article
- Nagging Presence ofJournal of clinical and diagnostic research : JCDR · 2017Article
- Molecular Epidemiology of Clostridium difficile Infection in Hospitalized Patients in Eastern China.Journal of clinical microbiology · 2017Article
- Article
- Molecular Epidemiology and Antimicrobial Susceptibility ofFrontiers in microbiology · 2016Article
- Predominance of Clostridium difficile Ribotypes 017 and 078 among Toxigenic Clinical Isolates in Southern Taiwan.PloS one · 2016Article
- Review
Corrections and comments
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Authors and funding
16 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundClostridium difficile carriage has been considered as a potential source for the deadly infection, but its role in cancer patients is still unclear. We aimed to identify the clinical and immunological factors that are related to C. difficile carriage in Chinese cancer patients.
methodsA total of 400 stool samples were collected from cancer patients who received chemotherapy in three hospitals of eastern China. Bacterial genomic DNA was extracted and two toxin genes (tcdA and tcdB) were detected. PCR ribotyping was performed using capillary gel electrophoresis. Concentrations of prostaglandin E2 (PGE2), transforming growth factor beta (TGF-β) and interleukin-10 (IL-10) were measured using enzyme-linked immunosorbent assay (ELISA) kits.
resultsEighty-two (20.5%) samples were confirmed to be C. difficile-positive and positive for tpi, tcdA, and tcdB genes. The C. difficile-positive rates in patients with diarrhea and no diarrhea were 35% and 19.7%, respectively (p = 0.09). Patients who were younger than 50 years old and were hospitalized for at least 10 days had a C. difficile-positive rate as high as 35%. In contrast, patients who were older than 50 years old and were hospitalized for less than 10 days had a C. difficile-positive rate of only 12.7% (p = 0.0009). No association was found between C. difficile carriage and chemotherapy regimen, antibiotic drug use, or immunosuppressive mediators, such as prostaglandin E2 (PGE2), transforming growth factor beta (TGF-β), or interleukin-10 (IL-10). Twelve ribotypes of C. difficile were identified, but none of them belonged to ribotype 027.
conclusionsWe conclude that younger patients and those with longer hospitalization stays may be more prone to C. difficile carriage. Studies of larger populations are warranted to clarify the exact role of C. difficile carriage in hospitalized cancer patients in China.
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