ArticleLab on a chip2014
Mechanical phenotyping of breast cancer using MEMS: a method to demarcate benign and cancerous breast tissues.
Article in Lab on a chip, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Transformative insights in breast cancer: review of atomic force microscopy applications.Discover oncology · 2025Review
- Biogenic nanoparticles: pioneering a new era in breast cancer therapeutics-a comprehensive review.Discover nano · 2024Review
- RapidET: a MEMS-based platform for label-free and rapid demarcation of tumors from normal breast biopsy tissues.Microsystems & nanoengineering · 2022Article
- Recent advances in microsystem approaches for mechanical characterization of soft biological tissues.Microsystems & nanoengineering · 2022Review
- Miniaturized electromechanical devices for the characterization of the biomechanics of deep tissue.Nature biomedical engineering · 2021Article
- Electromechanical Coupling Factor of Breast Tissue as a Biomarker for Breast Cancer.IEEE transactions on bio-medical engineering · 2018Article
- Toward a Portable Cancer Diagnostic Tool Using a Disposable MEMS-Based Biochip.IEEE transactions on bio-medical engineering · 2016Article
- Increased peri-ductal collagen micro-organization may contribute to raised mammographic density.Breast cancer research : BCR · 2016Article
- Design and fabrication of a flexible MEMS-based electromechanical sensor array for breast cancer diagnosis.Journal of micromechanics and microengineering : structures, devices, and systems · 2015Article
- Simultaneous MEMS-based electro-mechanical phenotyping of breast cancer.Lab on a chip · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The mechanical properties of tissue change significantly during the progression from healthy to malignant. Quantifying the mechanical properties of breast tissue within the tumor microenvironment can help to delineate benign from cancerous stages. In this work, we study high-grade invasive ductal carcinoma in comparison with their matched tumor adjacent areas, which exhibit benign morphology. Such paired tissue cores obtained from eight patients were indented using a MEMS-based piezoresistive microcantilever, which was positioned within pre-designated epithelial and stromal areas of the specimen. Field emission scanning electron microscopy studies on breast tissue cores were performed to understand the microstructural changes from benign to malignant. The normal epithelial tissues appeared compact and organized. The appearance of cancer regions, in comparison, not only revealed increased cellularity but also showed disorganization and increased fenestration. Using this technique, reliable discrimination between epithelial and stromal regions throughout both benign and cancerous breast tissue cores was obtained. The mechanical profiling generated using this method has the potential to be an objective, reproducible, and quantitative indicator for detecting and characterizing breast cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.