Evidence map›Paper›PMID 25267097›Full record

ArticlePediatric obesity2014

Longitudinal changes in infant body composition: association with childhood obesity.

M B Koontz, D D Gunzler, L Presley, P M Catalano

Registry-linked trialAbstract read
In one paragraph

Article in Pediatric obesity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03146156 (Lifestyle Intervention in Preparation for Pregnancy), which is not on this map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03146156 nacompletednot on this mapstarted 2017, after this paper: background citation

Lifestyle Intervention in Preparation for Pregnancy (LIPP)

TypeinterventionalSponsorTufts Medical CenterRan2017 to 2025Enrolled99ConditionsObesity, Lifestyle-related Condition, Macrosomia, FetalArmsLifestyle Intervention
3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Beyond Deterministic Fetal Programming: Intrauterine Exposures and the Multifactorial Origins of Adiposity.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
    Review
  3. Bedside ultrasound imaging to measure muscle cross-sectional area in preterm and term infants: a feasibility study.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
  4. Review
  5. Infant social withdrawal and rapid infant weight gain.International journal of obesity (2005) · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Infant body composition: A comprehensive overview of assessment techniques, nutrition factors, and health outcomes.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2023
    Review
  12. Article
  13. Article
  14. Article
  15. Observational
  16. Article
  17. Review
  18. Fetal programming of human energy homeostasis brain networks: Issues and considerations.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

M B KoontzDepartment of Pediatrics, Rainbow Babies & Children's Hospital, Case Western Reserve University, Cleveland, OH, USA.
D D Gunzler
L Presley
P M Catalano

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024989 · NCRR · CASE WESTERN RESERVE UNIVERSITY · PI DAVIS, PAMELA B · 2007 to 2011
$53.7M
Zosuquidar trihydrochloride for acute myeloid leukemia &refractory anemiaM01RR000080 · NCRR · UNIVERSITY HOSPITALS OF CLEVELAND · PI DAVIS, PAMELA B · 1985 to 2007
$22.2M
Clinical and Translational Science Collaborative of ClevelandKL2TR000440 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$11.1M
PERINATAL STUDIES OF DISORDERS OF FETAL METABOLISMP01HD011089 · NICHD · CASE WESTERN RESERVE UNIVERSITY · PI KALHAN, SATISH C · 1998 to 2002
$2.4M
INSULIN RESISTANCE AND GLUCOSE METABOLISM IN PREGNANCYR01HD022965 · NICHD · CASE WESTERN RESERVE UNIVERSITY · PI CATALANO, PATRICK · 1994 to 2011
$2.3M
THE METABOLIC ROLE OF EPINEPHRINE AROUND BIRTH AND IN CHILDHOODP50HD011089 · NICHD · CASE WESTERN RESERVE UNIVERSITY · PI KALHAN, SATISH C · 1985 to 1997
–
NCATS NIH HHS KL2 TR000440NCRR NIH HHS M01 RR000080NCRR NIH HHS M01 RR00080NCRR NIH HHS UL1 RR024989NICHD NIH HHS HD-11089NICHD NIH HHS R01 HD022965
6 · The paper itself

Abstract

backgroundRapid weight gain in infancy has been established as a risk factor for the development of later obesity.

objectiveWe aimed to investigate the role of changes in infant body composition (assessed via total body electrical conductivity) on the development of overweight/obesity in mid-childhood.

methodsFifty-three term infants were evaluated at birth, three times during infancy and in mid-childhood. Logistic regression was used to determine associations between rates of total weight gain, fat mass gain and lean mass gain during infancy and later overweight/obesity (defined as body mass index [BMI] ≥85th percentile), adjusted for birth weight and parent education.

resultsAt follow-up (age 9.0 ± 1.8 years), 30% were overweight/obese. More rapid total weight gain from 0 to 4 months was associated with twofold odds (odds ratio [OR] 1.98, 95% confidence interval [CI] 1.05-3.74, P = 0.04) of overweight/obesity in mid-childhood. From 0 to 8 months, more rapid weight gain was associated with nearly fivefold odds (OR 4.76, 95% CI 1.05-21.5, P = 0.04), and more rapid fat mass gain was associated with eightfold odds (OR 8.03, 95% CI 1.11-58.2, P = 0.04) of later overweight/obesity.

conclusionThis exploratory study suggests that rapid weight gain, especially fat mass gain, in earlier infancy predisposes to mid-childhood overweight/obesity.

Indexed as

Body CompositionWeight GainBirth WeightBody Mass IndexCausalityChildChild, PreschoolFemaleFollow-Up StudiesHumansInfantInfant, NewbornLogistic ModelsLongitudinal StudiesMaleMothersInfant fat massinfant weight gainperinatal programming

Identifiers

PMID25267097
PMCPMC4702488

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.