Evidence map›Paper›PMID 25267073›Full record

ReviewStem cell research2014

Cardiac stem cell niches.

Annarosa Leri, Marcello Rota, Toru Hosoda, Polina Goichberg, Piero Anversa

Open access · goldAbstract readReview
In one paragraph

Review in Stem cell research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 77 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Annarosa LeriDepartments of Anesthesia and Medicine, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: aleri@partners.org.
Marcello RotaDepartments of Anesthesia and Medicine, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Toru HosodaDepartments of Anesthesia and Medicine, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Polina GoichbergDepartments of Anesthesia and Medicine, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Piero AnversaDepartments of Anesthesia and Medicine, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: panversa@partners.org.
Brigham and Women's Hospital · USHarvard University · US

Funding

Tumor Necrosis Factor Modulation of CPCsP01HL078825 · NHLBI · UNIVERSITY OF LOUISVILLE · PI BOLLI, ROBERTO · 2005 to 2021
$37.6M
Rebuilding the Failing HeartP01HL092868 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ANVERSA, PIERO · 2008 to 2013
$12.9M
Stem Cells and Cardiac AgingP01AG023071 · NIA · NEW YORK MEDICAL COLLEGE · PI ANVERSA, PIERO · 2004 to 2008
$9.5M
Repair and Angiogenesis by Stem Cells in Human HeartR37HL081737 · NHLBI · NEW YORK MEDICAL COLLEGE · PI ANVERSA, PIERO · 2005 to 2015
$6.5M
Coronary Vasculature Progenitor Cell in Human Ischemic Heart FailureR01HL039902 · NHLBI · NEW YORK UNIVERSITY · PI ANVERSA, PIERO, KAJSTURA, JAN · 1989 to 2012
$4.7M
Stem Cells and Myocardial Aging in DogsP01AG043353 · NIA · UNIVERSITY OF ALBUQUERQUE · PI ANVERSA, PIERO · 2013 to 2015
$4.5M
MYOCYTE STEM CELLS IN THE MAMMALIAN HEARTR01HL065577 · NHLBI · NEW YORK MEDICAL COLLEGE · PI LERI, ANNAROSA · 2000 to 2012
$2.9M
Stem Cells in the Developing HeartR01HL091021 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ROTA, MARCELLO · 2009 to 2013
$2.4M
Redefining Human Myocardial BiologyR01HL105532 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ANVERSA, PIERO, BUCHHOLZ, BRUCE A · 2011 to 2014
$2.2M
Immortal DNA Strand and Cardiac Stem Cell AgingR01AG037495 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI ANVERSA, PIERO · 2011 to 2014
$2.0M
Telomeric Shortening, p53 and miR-34a Condition Senescence of Cardiac ProgenitorsR01AG037490 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI LERI, ANNAROSA · 2010 to 2014
$1.7M
Cardiomyogenesis in the Adult HeartR01HL114346 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LERI, ANNAROSA, ROTA, MARCELLO · 2012 to 2015
$1.7M
NHLBI NIH HHS P01 HL078825NHLBI NIH HHS P01 HL092868NHLBI NIH HHS R01 HL039902NHLBI NIH HHS R01 HL065577NHLBI NIH HHS R01 HL091021NHLBI NIH HHS R01 HL105532NHLBI NIH HHS R01 HL111183NHLBI NIH HHS R01 HL114346NHLBI NIH HHS R37 HL081737NIA NIH HHS P01 AG023071NIA NIH HHS P01 AG043353NIA NIH HHS R01 AG026107NIA NIH HHS R01 AG037490NIA NIH HHS R01 AG037495NIA NIH HHS R01 AG044455
6 · The paper itself

Abstract

The critical role that stem cell niches have in cardiac homeostasis and myocardial repair following injury is the focus of this review. Cardiac niches represent specialized microdomains where the quiescent and activated state of resident stem cells is regulated. Alterations in niche function with aging and cardiac diseases result in abnormal sites of cardiomyogenesis and inadequate myocyte formation. The relevance of Notch1 signaling, gap-junction formation, HIF-1α and metabolic state in the regulation of stem cell growth and differentiation within the cardiac niches are discussed.

Indexed as

Stem Cell NicheAnimalsHeartHumansMyocardiumStem Cells

Identifiers

PMID25267073
PMCPMC4253904
OpenAlexW2048692770

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.