ArticleImmunogenetics2014
Characterisation of non-classical MHC class I genes in the Tasmanian devil (Sarcophilus harrisii).
Article in Immunogenetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Improved high-throughput MHC typing for non-model species using long-read sequencing.Molecular ecology resources · 2022Pooled it
- Restoring faith in conservation action: Maintaining wild genetic diversity through the Tasmanian devil insurance program.iScience · 2022Article
- Expression of the Nonclassical MHC Class I, Saha-UD in the Transmissible Cancer Devil Facial Tumour Disease (DFTD).Pathogens (Basel, Switzerland) · 2022Article
- The differentiation state of the Schwann cell progenitor drives phenotypic variation between two contagious cancers.PLoS pathogens · 2021Article
- NLRC5 regulates expression of MHC-I and provides a target for anti-tumor immunity in transmissible cancers.Journal of cancer research and clinical oncology · 2021Article
- Deciphering genetic mate choice: Not so simple in group-housed conservation breeding programs.Evolutionary applications · 2020Article
- Marking vertebrates langerhans cells, from fish to mammals.Acta histochemica · 2020Review
- Review
- Lessons learnt from the Tasmanian devil facial tumour regarding immune function in cancer.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Review
- Article
- Characterisation of MHC class I genes in the koala.Immunogenetics · 2018Article
- The role of MHC genes in contagious cancer: the story of Tasmanian devils.Immunogenetics · 2017Review
- Expression and trafficking of MR1.Immunology · 2017Review
- Mammalian CD1 and MR1 genes.Immunogenetics · 2016Review
- Location, location, location: the evolutionary history of CD1 genes and the NKR-P1/ligand systems.Immunogenetics · 2016Review
- Characterization of a non-classical MHC class II gene in the vulnerable Chinese egret (Egretta eulophotes).Immunogenetics · 2015Article
- Immunomics of the koala (Phascolarctos cinereus).Immunogenetics · 2015Article
- Diversity in the Toll-like receptor genes of the Tasmanian devil (Sarcophilus harrisii).Immunogenetics · 2015Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Tasmanian devil (Sarcophilus harrisii) is a carnivorous marsupial that is under threat of extinction due to an unusual transmissible disease called Devil Facial Tumour Disease (DFTD). Previous studies on the classical MHC genes have provided important insights into immune responses in this endangered species; however, so far, very little is known about the non-classical MHC genes of this species, which can also play significant roles in the immune system. Here, we report characterisation of five non-classical class I genes in the Tasmanian devil, including Saha-UD, -UK, -UM, -MR1 and -CD1. Saha-UD has been isolated previously and is known to have low genetic polymorphism, though its categorisation as classical or non-classical gene has remained undetermined. In this study, we observed tissue-specific expression of Saha-UD, suggesting that it is more characteristic of a non-classical gene. Restricted tissue expression patterns were also observed for other genes, with an exception of Saha-MR1 being ubiquitously expressed in all examined tissues. Saha-UK, -UM and -MR1 were found to be genetically monomorphic, while four alleles were found at Saha-CD1 with signs of positive selection detected within the α1 domain. Among the four Saha-CD1 alleles, one predominant allele (Saha-CD1*01) showed a high allele frequency of 0.906 in the Tasmanian devil population, resulting in a low heterozygosity (0.188) at this locus. Alternative splicing takes place in Saha-CD1, giving rise to a full-length transcript and a splice variant lacking intact antigen-binding, β2m-binding, transmembrane and cytoplasmic domains.
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