Evidence map›Paper›PMID 25266921›Full record

ArticleTuberculosis (Edinburgh, Scotland)2014

MPT64 polymorphisms of Mycobacterium tuberculosis strains suggest ongoing immune evasion.

Yi Jiang, Haican Liu, Kanglin Wan

Abstract readComment
PubMed Publisher
In one paragraph

Article in Tuberculosis (Edinburgh, Scotland), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Antibodies and tuberculosis.Tuberculosis (Edinburgh, Scotland) · 2016
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Yi JiangState Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, PR China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou 310003, PR China.
Haican LiuState Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, PR China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou 310003, PR China.
Kanglin WanState Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, PR China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou 310003, PR China. Electronic address: wankanglin@icdc.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In our previous study, we found that polymorphisms of the mpt64 gene in the Mycobacterium tuberculosis complex (MTBC) may be the reason for changes in the antigen produced, which may in turn cause alterations of related functions. Based on the data, we further analyzed T/B cell epitope regions and non-epitope regions and compared amino acid changes between them. It turned out the polymorphisms of MPT64 affected both T cell epitopes and B cell epitopes, which thus influenced cell-mediated immunity and humoral immunity at the same time. Both T cell epitope regions and B cell epitope regions had higher dN/dS values than corresponding non-epitope regions, which means the formers have accumulated significantly more amino acid changes than the latters.

Indexed as

Antigens, BacterialHumansMycobacterium tuberculosisAntigens, BacterialImmune evasionMPT64 polymorphismsMycobacterium tuberculosis

Identifiers

PMID25266921

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.