Evidence map›Paper›PMID 25266844›Full record

ArticleScandinavian journal of work, environment & health2014

Exposure-response relationships for the ACGIH threshold limit value for hand-activity level: results from a pooled data study of carpal tunnel syndrome.

Jay M Kapellusch, Frederic E Gerr, Elizabeth J Malloy, Arun Garg, Carisa Harris-Adamson, Stephen S Bao, Susan E Burt, Ann Marie Dale, Ellen A Eisen, Bradley A Evanoff and 4 more

Open access · hybridAbstract read
In one paragraph

Article in Scandinavian journal of work, environment & health, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
5.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 60 citations in OpenAlex.

  1. Article
  2. Occupational demands associated with rotator cuff disease surgery in the UK Biobank.Scandinavian journal of work, environment & health · 2023
    Article
  3. Article
  4. Article
  5. Article
  6. Modeling the Effect of the 2018 Revised ACGIHJournal of occupational and environmental hygiene · 2019
    Article
  7. Article
  8. Article
  9. Article
  10. Carpal tunnel syndrome prevalence: an evaluation of workers at a raw poultry processing plant.International journal of occupational and environmental health · 2017
    Article
  11. Article
  12. Article
  13. Impact of Work Organizational Factors on Carpal Tunnel Syndrome and Epicondylitis.Journal of occupational and environmental medicine · 2016
    Article
  14. Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 10 institutions in 1 country.

Jay M KapelluschDepartment of Occupational Science & Technology University of Wisconsin, Milwaukee, PO Box 413 Milwaukee, WI 53201, USA. kap@uwm.edu.
Frederic E Gerr
Elizabeth J Malloy
Arun Garg
Carisa Harris-Adamson
Stephen S Bao
Susan E Burt
Ann Marie Dale
Ellen A Eisen
Bradley A Evanoff
Kurt T Hegmann
Barbara A Silverstein
Matthew S Theise
David M Rempel
United States Department of State · USUniversity of California, Berkeley · USWashington University in St. Louis · USAmerican University · USNational Institute for Occupational Safety and Health · USRocky Mountain University of Health Professions · USUniversity of California, San Francisco · USUniversity of Iowa · USUniversity of Utah · USUniversity of Wisconsin–Milwaukee · US

Funding

Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI HANS-JOACHIM LEHMLER · 1990 to 2026
$40.5M
A Pooled Longitudinal Analysis of Workplace Carpal Tunnel SyndromeR01OH009712 · OH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI REMPEL, DAVID M · 2010 to 2012
$1.5M
NCATS NIH HHS UL1 TR000448NIEHS NIH HHS P30 ES005605NIOSH CDC HHS R01 OH009712NIOSH CDC HHS R01OH009712
6 · The paper itself

Abstract

objectivesThis paper aimed to quantify exposure-response relationships between the American Conference of Governmental Industrial Hygienists' (ACGIH) threshold limit value (TLV) for hand-activity level (HAL) and incidence of carpal tunnel syndrome (CTS).

methodsManufacturing and service workers previously studied by six research institutions had their data combined and re-analyzed. CTS cases were defined by symptoms and abnormal nerve conduction. Hazard ratios (HR) were calculated using proportional hazards regression after adjusting for age, gender, body mass index, and CTS predisposing conditions.

resultsThe longitudinal study comprised 2751 incident-eligible workers, followed prospectively for up to 6.4 years and contributing 6243 person-years of data. Associations were found between CTS and TLV for HAL both as a continuous variable [HR 1.32 per unit, 95% confidence interval (95% CI) 1.11-1.57] and when categorized using the ACGIH action limit (AL) and TLV. Those between the AL and TLV and above the TLV had HR of 1.7 (95% CI 1.2-2.5) and 1.5 (95% CI 1.0-2.1), respectively. As independent variables (in the same adjusted model) the HR for peak force (PF) and HAL were 1.14 per unit (95% CI 1.05-1.25), and 1.04 per unit (95% CI 0.93-1.15), respectively.

conclusionThose with exposures above the AL were at increased risk of CTS, but there was no further increase in risk for workers above the TLV. This suggests that the current AL may not be sufficiently protective of workers. Combinations of PF and HAL are useful for predicting risk of CTS.

Indexed as

HandOccupational ExposureAdolescentAdultAgedBiomechanical PhenomenaCarpal Tunnel SyndromeFemaleHumansMaleMiddle AgedRisk FactorsThreshold Limit ValuesYoung Adult

Identifiers

PMID25266844
PMCPMC4251712
OpenAlexW2040727953

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.