ArticleEpilepsia2014
Genetic testing preferences in families containing multiple individuals with epilepsy.
Article in Epilepsia, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Genetic attribution and perceived impact of epilepsy in multiplex epilepsy families.Epilepsia · 2019Article
- Article
- Mood disorders in familial epilepsy: A test of shared etiology.Epilepsia · 2018Article
- Genetic Testing Preferences of Individuals in Families with Essential Tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2018Article
- [Epilepsy-new diagnostic tools, old drugs? : Therapeutic consequences of epilepsy genetics].Der Nervenarzt · 2017Review
- Depression and genetic causal attribution of epilepsy in multiplex epilepsy families.Epilepsia · 2016Article
- Parents' interest in genetic testing of their offspring in multiplex epilepsy families.Epilepsia · 2016Article
- Article
- Attitudes Toward Epilepsy Genetics Testing Among Adult and Pediatric Epileptologists-Results of a Q-PULSE Survey.Epilepsy currentsArticle
- Genetics of Epilepsy in Clinical Practice.Epilepsy currentsArticle
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveTo examine genetic testing preferences in families containing multiple individuals with epilepsy.
methodsOne hundred forty-three individuals with epilepsy and 165 biologic relatives without epilepsy from families containing multiple affected individuals were surveyed using a self-administered questionnaire. Four genetic testing scenarios were presented, defined by penetrance (100% vs. 50%) and presence or absence of clinical utility. Potential predictors of genetic testing preferences were evaluated using generalized estimating equations with robust Poisson regression models. The influence of 21 potential testing motivations was also assessed.
resultsFor the scenario with 100% penetrance and clinical utility, 85% of individuals with epilepsy and 74% of unaffected relatives responded that they would definitely or probably want genetic testing. For the scenario with 100% penetrance but without clinical utility, the proportions who responded that they would want testing were significantly lower in both affected individuals (69%) and unaffected relatives (57%). Penetrance (100% vs. 50%) was not a significant predictor of genetic testing interest. The highest-ranking motivations for genetic testing were the following: the possibility that the results could improve health or health care, the potential to know if epilepsy in the family is caused by a gene, and the possibility of changing behavior or lifestyle to prevent seizures. SIGNIFICANCE: Interest in epilepsy genetic testing may be high in affected and unaffected individuals in families containing multiple individuals with epilepsy, especially when testing has implications for improving clinical care.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.