ArticleJournal of dental research2014
Deterioration of mechanical properties of discs in chronically inflamed TMJ.
Article in Journal of dental research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 50 citations in OpenAlex.
- CBCT-MRI-based prediction models for stratifying anterior disc displacement in orthodontic patients: development and independent internal validation of a retrospective diagnostic study.Oral radiology · 2026Article
- Inflammation-related collagen fibril destruction contributes to temporomandibular joint disc displacement via NF-κB activation.International journal of oral science · 2025Article
- Development of animal model for anterior open bite and mechanism of temporomandibular joint morphological change: an implication for MAC surgery.BMC oral health · 2025Article
- Energy metabolism dysfunction and therapeutic strategies for treating temporomandibular disorders.Frontiers in medicine · 2025Review
- Endo 180 participates in collagen remodeling of the periodontal ligament during orthodontic tooth movement.BMC oral health · 2024Article
- Article
- Psoriatic Arthritis Involving TMJ: A Review on Pathogenesis and Consideration on Eventual Gender Differences.Dentistry journal · 2024Review
- Causal relationship between psychiatric traits and temporomandibular disorders: a bidirectional two-sample Mendelian randomization study.Clinical oral investigations · 2023Article
- An artificial intelligence model for the radiographic diagnosis of osteoarthritis of the temporomandibular joint.Scientific reports · 2023Article
- Temporomandibular Joint Osteoarthritis: Pathogenic Mechanisms Involving the Cartilage and Subchondral Bone, and Potential Therapeutic Strategies for Joint Regeneration.International journal of molecular sciences · 2022Review
- Molecular signaling in temporomandibular joint osteoarthritis.Journal of orthopaedic translation · 2022Review
- Chronic inflammation deteriorates structure and function of collagen fibril in rat temporomandibular joint disc.International journal of oral science · 2019Article
- Characterization of a rat model with temporomandibular joint osteoarthritis following a surgical anterior disc displacement.American journal of translational research · 2018Article
- Mesenchymal Stem Cells for Cartilage Regeneration of TMJ Osteoarthritis.Stem cells international · 2017Review
- Excess BMP Signaling in Heterotopic Cartilage Forming in Prg4-null TMJ Discs.Journal of dental research · 2016Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Temporomandibular joint (TMJ) discs frequently undergo degenerative changes in arthritis. However, the biomechanical properties of pathogenic discs remain to be explored. In this study, we evaluated the effects of chronic inflammation on the biomechanical properties of TMJ discs in rats. Chronic inflammation of TMJs was induced by double intra-articular injections of complete Freund's adjuvant for 5 weeks, and biomechanical properties and ultrastructure of the discs were examined by mechanical testing, scanning electron microscopy, and transmission electron microscopy. The instantaneous compressive moduli of the anterior and posterior bands of discs in inflamed TMJs were decreased significantly compared with those in the control group. The instantaneous tensile moduli of the discs of inflamed TMJs also showed significant decreases in both the anterior-posterior and mesial-lateral directions. The relaxation moduli of the discs of inflamed TMJs showed nearly the same tendency as the instantaneous moduli. The surfaces of the discs of inflamed TMJs became rough and porous due to the loss of the superficial gel-like stratum, with many collagen fibers exposed and degradation of the sub-superficial collagen fibrils. Our results suggested that chronic inflammation of TMJ could lead to deterioration of mechanical properties and alteration of disc ultrastructure, which might contribute to TMJ disc displacement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.