ArticleMolecular and cellular biology2014
The microRNA 424/503 cluster reduces CDC25A expression during cell cycle arrest imposed by transforming growth factor β in mammary epithelial cells.
Article in Molecular and cellular biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- Endometrial cancer progression driven by PTEN-deficiency requires miR-424(322)Cell death & disease · 2025Article
- Harnessing TGF-β signaling to improve testicular organoid development from dissociated testicular cells.Stem cell research & therapy · 2025Article
- A microRNA Cluster Controls Fat Cell Differentiation and Adipose Tissue Expansion By Regulating SNCG.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- The Role of microRNAs in the Mammary Gland Development, Health, and Function of Cattle, Goats, and Sheep.Non-coding RNA · 2021Review
- miR-424/503 modulates Wnt/β-catenin signaling in the mammary epithelium by targeting LRP6.EMBO reports · 2021Article
- H19X-encoded miR-322(424)/miR-503 regulates muscle mass by targeting translation initiation factors.Journal of cachexia, sarcopenia and muscle · 2021Article
- Can MiR-503 be used as a marker in diabetic patients with ischemic stroke?BMC endocrine disorders · 2019Article
- miR-424 coordinates multilayered regulation of cell cycle progression to promote esophageal squamous cell carcinoma cell proliferation.EBioMedicine · 2018Article
- Emerging therapeutics in pulmonary hypertension.American journal of physiology. Lung cellular and molecular physiology · 2018Review
- miR-424-5p reduces ribosomal RNA and protein synthesis in muscle wasting.Journal of cachexia, sarcopenia and muscle · 2018Article
- miR-322-5p targets IGF-1 and is suppressed in the heart of rats with pulmonary hypertension.FEBS open bio · 2018Article
- Glucose insult elicits hyperactivation of cancer stem cells through miR-424-cdc42-prdm14 signalling axis.British journal of cancer · 2017Article
- Ly6G+ neutrophil-derived miR-223 inhibits the NLRP3 inflammasome in mitochondrial DAMP-induced acute lung injury.Cell death & disease · 2017Article
- Optimization of PAR-CLIP for transcriptome-wide identification of binding sites of RNA-binding proteins.Methods (San Diego, Calif.) · 2017Review
- miR-424(322)/503 is a breast cancer tumor suppressor whose loss promotes resistance to chemotherapy.Genes & development · 2017Article
- Mammary Gland Involution Provides a Unique Model to Study the TGF-β Cancer Paradox.Journal of clinical medicine · 2017Review
- Blocking Smad2 signalling with loganin attenuates SW10 cell cycle arrest induced by TNF-α.PloS one · 2017Article
- miR-322/-503 cluster is expressed in the earliest cardiac progenitor cells and drives cardiomyocyte specification.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- MicroRNA-424 Predicts a Role for β-1,4 Branched Glycosylation in Cell Cycle Progression.The Journal of biological chemistry · 2016Article
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Authors and funding
14 authors at 4 institutions in 1 country.
Funding
Abstract
Recently, we demonstrated that the microRNA 424(322)/503 [miR-424(322)/503] cluster is transcriptionally controlled by transforming growth factor β (TGF-β) in the mammary epithelium. Induction of this microRNA cluster impacts mammary epithelium fate by regulating apoptosis and insulin-like growth factor 1 (IGF1) signaling. Here, we expanded our finding to demonstrate that miR-424(322)/503 is an integral component of the cell cycle arrest mediated by TGF-β. Mechanistically, we showed that after TGF-β exposure, increased levels of miR-424(322)/503 reduce the expression of the cell cycle regulator CDC25A. miR-424(322)/503-dependent posttranscriptional downregulation of CDC25A cooperates with previously described transcriptional repression of the CDC25A promoter and proteasome-mediated degradation to reduce the levels of CDC25A expression and to induce cell cycle arrest. We also provide evidence that the TGF-β/miR-424(322)/503 axis is part of the mechanism that regulates the proliferation of hormone receptor-positive (HR(+)) mammary epithelial cells in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.