ArticleThe American journal of tropical medicine and hygiene2014
Evaluation of a new handheld instrument for the detection of counterfeit artesunate by visual fluorescence comparison.
Article in The American journal of tropical medicine and hygiene, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Hide and seek with falsified medicines: Current challenges and physico-chemical and biological approaches for tracing the origin of trafficked products.Forensic science international · 2025Review
- A random survey of the prevalence of falsified and substandard antibiotics in the Lao PDR.The Journal of antimicrobial chemotherapy · 2022Article
- Negative Consequences of the Widespread and Inappropriate Easy Access to Purchasing Prescription Medications on the Internet.American health & drug benefits · 2021Review
- Evaluating Low-Cost Optical Spectrometers for the Detection of Simulated Substandard and Falsified Medicines.Applied spectroscopy · 2020Article
- Survey to Identify Substandard and Falsified Tablets in Several Asian Countries with Pharmacopeial Quality Control Tests and Principal Component Analysis of Handheld Raman Spectroscopy.The American journal of tropical medicine and hygiene · 2018Article
- Are we doing enough to prevent poor-quality antimalarial medicines in the developing world?BMC public health · 2018Article
- Global landscape assessment of screening technologies for medicine quality assurance: stakeholder perceptions and practices from ten countries.Globalization and health · 2018Article
- Article
- Field detection devices for screening the quality of medicines: a systematic review.BMJ global health · 2018Article
- Classification and Visualization of Physical and Chemical Properties of Falsified Medicines with Handheld Raman Spectroscopy and X-Ray Computed Tomography.The American journal of tropical medicine and hygiene · 2017Article
- A New Handheld Device for the Detection of Falsified Medicines: Demonstration on Falsified Artemisinin-Based Therapies from the Field.The American journal of tropical medicine and hygiene · 2017Article
- Essential medicines for universal health coverage.Lancet (London, England) · 2017Review
- Combating poor-quality anti-malarial medicines: a call to action.Malaria journal · 2016Review
- Article
- Assessment of the effectiveness of the CD3+ tool to detect counterfeit and substandard anti-malarials.Malaria journal · 2016Article
- Integration of novel low-cost colorimetric, laser photometric, and visual fluorescent techniques for rapid identification of falsified medicines in resource-poor areas: application to artemether-lumefantrine.The American journal of tropical medicine and hygiene · 2015Article
- Responding to the pandemic of falsified medicines.The American journal of tropical medicine and hygiene · 2015Article
- A Repeat Random Survey of the Prevalence of Falsified and Substandard Antimalarials in the Lao PDR: A Change for the Better.The American journal of tropical medicine and hygiene · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
There is an urgent need for accurate and inexpensive handheld instruments for the evaluation of medicine quality in the field. A blinded evaluation of the diagnostic accuracy of the Counterfeit Detection Device 3 (CD-3), developed by the US Food and Drug Administration Forensic Chemistry Center, was conducted in the Lao People's Democratic Republic. Two hundred three samples of the oral antimalarial artesunate were compared with authentic products using the CD-3 by a trainer and two trainees. The specificity (95% confidence interval [95% CI]), sensitivity (95% CI), positive predictive value (95% CI), and negative predictive value (95% CI) of the CD-3 for detecting counterfeit (falsified) artesunate were 100% (93.8-100%), 98.4% (93.8-99.7%), 100% (96.2-100%), and 97.4% (90.2-99.6%), respectively. Interobserver agreement for 203 samples of artesunate was 100%. The CD-3 holds promise as a relatively inexpensive and easy to use instrument for field evaluation of medicines, potentially empowering drug inspectors, customs agents, and pharmacists.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.