ReviewCell and tissue research2015
Tinnitus: animal models and findings in humans.
Review in Cell and tissue research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04862572 (Investigating Disinhibitory Brain Mechanism in Tinnitus and Hearing Loss), which is not on this map. Cited by 73 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigating Disinhibitory Brain Mechanism in Tinnitus and Hearing Loss: Is There a Maladaptive Signature of Auditory Cortex GABA Loss and Dysconnectivity?
Who cites it
73 citing papers in PubMed, 3 syntheses or guidelines pooled it, 149 citations in OpenAlex.
- Structural and functional brain alterations in patients with hyperacusis: MRI systematic review.Frontiers in human neuroscience · 2026Pooled it
- Using ALE coordinate-based meta-analysis to observe resting-state brain abnormalities in subjective tinnitus.Brain imaging and behavior · 2024Pooled it
- Cognitive behavioural therapy for tinnitus.The Cochrane database of systematic reviews · 2020Pooled it
- Vagus Nerve Stimulation Paired with Tones for the Treatment of Tinnitus: A Prospective Randomized Double-blind Controlled Pilot Study in Humans.Scientific reports · 2017Trial
- Review
- Tinnitus severity and hearing loss: mechanistic insights and future directions.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- A delayed pharmacological treatment strategy attenuates noise-induced tinnitus in rats.Scientific reports · 2026Article
- From Anatomy to Application: A Comprehensive Review of Nanovesicular Systems for Otic Drug Delivery.AAPS PharmSciTech · 2026Review
- Molecular remodeling of the central auditory pathway in tinnitus revealed by RNA sequencing.Genes & genomics · 2026Article
- Rediscovery of a seventh sense: humans produce, perceive, and process ultrasound.Frontiers in neuroscience · 2026Article
- Musical Hallucinosis: Auditory Illusions After Hearing Loss and Cochlear Implantation.Neurorehabilitation and neural repair · 2025Review
- Objective autonomic signatures of tinnitus and sound sensitivity disorders.Science translational medicine · 2025Article
- Unravelling the Silence: Exploring Tinnitus Pathophysiology and the Promise of Traditional Chinese Medicine.International journal of general medicine · 2025Review
- Correlation of non-auditory comorbidities and hearing loss in chronic subjective tinnitus patients: a retrospective database study.Frontiers in neurology · 2025Article
- Decoding tinnitus progression: neurochemical shifts in the anterior cingulate cortex revealed by magnetic resonance spectroscopy.Frontiers in neuroscience · 2025Article
- Article
- Tinnitus is associated with increased extracellular matrix density in the auditory cortex of Mongolian gerbils.BMC neuroscience · 2024Article
- Sensory Inhibition and Tinnitus: Measurement of Auditory Gating.Seminars in hearing · 2024Review
- Tinnitus reduction in patients with single-sided deafness: the effect of cochlear implantation, bone conduction devices, and contralateral routing of sound hearing aids investigated in a randomized controlled trial.Frontiers in neurology · 2024Article
- Mid-Infrared Photons Alleviate Tinnitus by Activating the KCNQ2 Channel in the Auditory Cortex.Research (Washington, D.C.) · 2024Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic tinnitus (ringing of the ears) is a medically untreatable condition that reduces quality of life for millions of individuals worldwide. Most cases are associated with hearing loss that may be detected by the audiogram or by more sensitive measures. Converging evidence from animal models and studies of human tinnitus sufferers indicates that, while cochlear damage is a trigger, most cases of tinnitus are not generated by irritative processes persisting in the cochlea but by changes that take place in central auditory pathways when auditory neurons lose their input from the ear. Forms of neural plasticity underlie these neural changes, which include increased spontaneous activity and neural gain in deafferented central auditory structures, increased synchronous activity in these structures, alterations in the tonotopic organization of auditory cortex, and changes in network behavior in nonauditory brain regions detected by functional imaging of individuals with tinnitus and corroborated by animal investigations. Research on the molecular mechanisms that underlie neural changes in tinnitus is in its infancy and represents a frontier for investigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.