Evidence map›Paper›PMID 25266332›Full record

ArticleJournal of radiation research2015

Tumoricidal activity of low-energy 160-KV versus 6-MV X-rays against platinum-sensitized F98 glioma cells.

Sara N Lim, Anil K Pradhan, Rolf F Barth, Sultana N Nahar, Robin J Nakkula, Weilian Yang, Alycia M Palmer, Claudia Turro, Michael Weldon, Erica Hlavin Bell and 1 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of radiation research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sara N LimBiophysics Graduate Program, The Ohio State University, 113 Biological Sciences Building, 484 W 12th Avenue, Columbus, OH 43210, USA.
Anil K PradhanBiophysics Graduate Program, The Ohio State University, 113 Biological Sciences Building, 484 W 12th Avenue, Columbus, OH 43210, USA Department of Astronomy, The Ohio State University, 4055 McPherson Laboratory, 140 W 18th Avenue, Columbus, OH 43210, USA pradhan.1@osu.edu.
Rolf F BarthDepartment of Pathology, The Ohio State University, 4132 Graves Hall, 333 West 10th Avenue, Columbus, OH 43210, USA rolf.barth@osumc.edu.
Sultana N NaharDepartment of Astronomy, The Ohio State University, 4055 McPherson Laboratory, 140 W 18th Avenue, Columbus, OH 43210, USA.
Robin J NakkulaDepartment of Pathology, The Ohio State University, 4132 Graves Hall, 333 West 10th Avenue, Columbus, OH 43210, USA.
Weilian YangDepartment of Pathology, The Ohio State University, 4132 Graves Hall, 333 West 10th Avenue, Columbus, OH 43210, USA.
Alycia M PalmerDepartment of Chemistry and Biochemistry, The Ohio State University, Newman & Wolfrom Laboratory, 100 W 18th Avenue, OH 43210, USA.
Claudia TurroDepartment of Chemistry and Biochemistry, The Ohio State University, Newman & Wolfrom Laboratory, 100 W 18th Avenue, OH 43210, USA.
Michael WeldonDepartment of Radiation Oncology, The Ohio State University, 300 W 10th Avenue, Columbus, OH 43210, USA.
Erica Hlavin BellDepartment of Radiation Oncology, The Ohio State University, 300 W 10th Avenue, Columbus, OH 43210, USA.
Xiaokui MoCenter for Biostatistics, The Ohio State University, 2012 Kenny Road, Columbus, OH 43210, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purposes of this study were (i) to investigate the differences in effects between 160-kV low-energy and 6-MV high-energy X-rays, both by computational analysis and in vitro studies; (ii) to determine the effects of each on platinum-sensitized F98 rat glioma and murine B16 melanoma cells; and (iii) to describe the in vitro cytotoxicity and in vivo toxicity of a Pt(II) terpyridine platinum (Typ-Pt) complex. Simulations were performed using the Monte Carlo code Geant4 to determine enhancement in absorption of low- versus high-energy X-rays by Pt and to determine dose enhancement factors (DEFs) for a Pt-sensitized tumor phantom. In vitro studies were carried out using Typ-Pt and again with carboplatin due to the unexpected in vivo toxicity of Typ-Pt. Cell survival was determined using clonogenic assays. In agreement with computations and simulations, in vitro data showed up to one log unit reduction in surviving fractions (SFs) of cells treated with 1-4 µg/ml of Typ-Pt and irradiated with 160-kV versus 6-MV X-rays. DEFs showed radiosensitization in the 50-200 keV range, which fell to approximate unity at higher energies, suggesting marginal interactions at MeV energies. Cells sensitized with 1-5 or 7 µg/ml of carboplatin and then irradiated also showed a significant decrease (P < 0.05) in SFs. However, it was unlikely this was due to increased interactions. Theoretical and in vitro studies presented here demonstrated that the tumoricidal activity of low-energy X-rays was greater than that of high-energy X-rays against Pt-sensitized tumor cells. Determining whether radiosensitization is a function of increased interactions will require additional studies.

Indexed as

Models, BiologicalAbsorption, RadiationAnimalsAntineoplastic AgentsApoptosisCarboplatinCell Line, TumorCell SurvivalComputer SimulationDose-Response Relationship, RadiationMiceModels, StatisticalNeoplasms, ExperimentalParticle AcceleratorsRadiation DosageRadiation-Sensitizing AgentsAntineoplastic AgentsCarboplatinRadiation-Sensitizing AgentsB16 murine melanomacomparison of 160-kV vs 6-MV X-raysdose enhancement factorF98 rat gliomaplatinum radiosensitization

Identifiers

PMID25266332
PMCPMC4572599

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.