Evidence map›Paper›PMID 25266216›Full record

ArticleJournal of nephrology2015

The relationship between calcium kidney stones, arterial stiffness and bone density: unraveling the stone-bone-vessel liaison.

Antonia Fabris, Pietro Manuel Ferraro, Gabriele Comellato, Chiara Caletti, Francesco Fantin, Gianluigi Zaza, Mauro Zamboni, Antonio Lupo, Giovanni Gambaro

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In one paragraph

Article in Journal of nephrology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  10. Nephrolithiasis: A Red Flag for Cardiovascular Risk.Journal of clinical medicine · 2022
    Review
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  15. Article
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  17. The Activation of ROS/NF-Oxidative medicine and cellular longevity · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Antonia FabrisSection of Nephrology, Department of Medicine, University of Verona, Verona, Italy.
Pietro Manuel FerraroDivision of Nephrology, Department of Medical Sciences, Catholic University of the Sacred Heart, Via G. Moscati 31, 00168, Rome, Italy. pietromanuel.ferraro@rm.unicatt.it.
Gabriele ComellatoSection of Geriatrics, Department of Medicine, University of Verona, Verona, Italy.
Chiara CalettiSection of Nephrology, Department of Medicine, University of Verona, Verona, Italy.
Francesco FantinSection of Geriatrics, Department of Medicine, University of Verona, Verona, Italy.
Gianluigi ZazaSection of Nephrology, Department of Medicine, University of Verona, Verona, Italy.
Mauro ZamboniSection of Geriatrics, Department of Medicine, University of Verona, Verona, Italy.
Antonio LupoSection of Nephrology, Department of Medicine, University of Verona, Verona, Italy.
Giovanni GambaroDivision of Nephrology, Department of Medical Sciences, Catholic University of the Sacred Heart, Via G. Moscati 31, 00168, Rome, Italy. giovanni.gambaro@rm.unicatt.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesKidney stone disease is associated with a higher incidence of cardio-vascular (CV) events for still unclear reasons. Reduced bone density is also a frequent finding in calcium kidney stones. The association of reduced bone density with increased vascular stiffness and calcification has been discovered in a number of conditions. We investigated the hypothesis that patients with calcium kidney stones have increased arterial stiffness, which would be associated with reduced bone density and higher CV risk. DESIGN, SETTING, PARTICIPANTS, AND MEASUREMENTS: We compared measures of arterial stiffness [carotid-radial pulse-wave velocity (CR-PWV), carotid-femoral pulse-wave velocity (CF-PWV) and augmentation index (AI)] and of bone density (T-scores determined at lumbar spine, neck and hip) among 42 idiopathic calcium stone formers compared with 42 age- and sex-matched healthy volunteers.

resultsStone formers had higher values of CR-PWV, CF-PWV and AI, and lower values of all T-scores. Furthermore, the prevalence of abnormal arterial stiffness and reduced bone density was significantly higher among stone formers. Statistical adjustment for age, sex, body mass index and other covariates did not change the results.

conclusionsOur study confirms that stone formers have increased arterial stiffness and reduced bone density. Abnormal arterial stiffness appears to be independent of reduced bone density and may explain the higher CV risk observed in stone formers.

Indexed as

Absorptiometry, PhotonBlood Flow VelocityBlood VesselsBone DensityCalciumCardiovascular DiseasesFollow-Up StudiesHumansItalyKidney CalculiPrevalenceProspective StudiesPulse Wave AnalysisVascular StiffnessCalciumArterial stiffnessBone metabolismCardiovascular diseaseUrolithiasis

Identifiers

PMID25266216

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.